1273
www.onkologiecs.cz3408040010765133201214262311348396415464514532576617652669709748
12356558020012657110167
/39298040010732
Onkologie.40068040010760109147194214262312331375389
2025;19(3):119-1234415804001074487128172185223261285327348363400434472502540578622
/50828040010731
ONKOLOGIE51598040010761120167227270329388409453
HLAVNÍ4945200012671127198263336370
TÉMA5337200012657114204274
Časná404136001063274108149189
integrace42453600106155789121161196238271303
paliativní456436001063269100118158186204242283301
péče48803600106336599131
(nejen)50273600106236294121153194217
v5260360010636
onkologii531236001063880115154186225265282299
„Cancer340590014335102157221275331366
survivorship“735590014345107142201227281344380425489513579613
Kombinace480760010950102182237262316363407455
stárnoucí96676001093771119152206260313358382
populace,1379760010952107162216241288332380402
efektivnějších18127600109467612517234090001093155103158208233272297341395
a767900010944
rozšířenějších84390001093084126167191227276331381406445470514568
preventivních144390001095286135183231286319343391446471515570
programů340104001095182133186217263339390
a7501040010942
pokroků8121040010951103147180231275326
v11581040010943
protinádorové1221104001095082133164187239284336388419470514560
léčbě1801104001092168111163211
vede340118001094493148198
k5691180010943
vyšší644118001094494133172196
prevalenci872118001095285134181229254303358402426
pacientů13301180010952100144169218272305359
v17201180010944
dlouhodobé17961180010952761301843401320010951105161214270320
remisi691132001093179159184223247
nádorového969132001095198154207241294341389443497
onemocnění14971320010951105155235289334388437491516
(31).340146001092571114135153
Je513146001093279
nutné6121460010949100131182229
více861146001094266107153
zvažovat1033146001093885130171221265310341
dopady13941460010950101153199251295
rozhodnutí17091460010929791181702202733401600010950103135159
související529160001093689142188213251299324347391414
s9731600010936
léčbou1039160001092270114168222275
na1344160001095096
kvalitu1471160001094291138162185218271
života1772160001093963109161193240
pacientů.340174001095198141164212264296348369
Aby7331740010955109153
bylo910174001095195120172
možné11061740010975127168220268
účinně1398174001094992116168220268
uspokojit169017400109498714119423929034018800109224679
potřeby4501880010952106139171220275320
přeživších,801188001095284133175199246285309353406428
je1259188001092371
nezbytná13611880010951100142197242278332379
multidisciplinární17701880010976129154187211340202001095277116162186242268293347395429484508
spolupráce882202001093792148173227283317366411459
mezi13752020010977127171196
onkology,16042020010951106153206232286342390408
paliatry,340216001095198121145191222254302319
geriatry689216001095199131155200232264312
a10312160010944
poskytovateli11042160010952105143187235270322367413445492516539
primární1673216001095284108185231263316339
péče3402300010951100143190
(32).554230001092572118144164
Nové2140590014377141194252
toxicity242159001433799149175228253290347
spojené2796590014345111176201260324382
s2140730014345
imunoterapií2214730014325122185249314350406441497562588612
Imunoterapie,228090001092298147198248277322352396447469514532
která283790001094375120149194
se305590001093682
stala316190001093667111133176
významnou336190001094490131182225301351401451
součástí2140104001093584133172215249279299
onkologické2453104001094998139186207256306326365406449
léčby,2916104001092166106156196210
přináší3140104001095180100149191225245
nové3399104001095098140183
výzvy3596104001094387127172216
v21401180010942
podobě2195118001095199148196245289
imunitně2497118001092193140188207235283326
podmíněných2836118001095199148221240288331379418456503
nežádoucích3352118001094993130173221269317355375413460
účinků2140132001095090110159200249
(irAE,240413200109264674125168187
immune-related2606132001092195169218267312342372416437480508552603
adverse3224132001094394137180210245290
events),3529132001094587131181209245267283
které2140146001094375120150195
mohou23591460010976126177227277
postihnout26611460010952102138169189239289339390420
kterýkoliv3105146001094375120150195238287309329373
orgán3503146001095079130174224
či3751146001094162
tkáň.2140160001093174120171190
IrAE2356160001092353106151
mohou25341600010977128180231283
být2843160001095396130
závažné2999160001094086130175215266313
a33391600010944
vyžadovat3410160001094491133179232283327372402
zcela2140174001093978122143185
nové2343174001095099141184
přístupy2545174001095180100135165213264305
k28671740010943
symptomové2927174001093678154204233281356405447491
péči3435174001095197137157
(37).3610174001092569112137153
Závěr21401990014768131190250294
Paliativní2280216001094993115137182213235280332354
péče26612160010952100142188
v28762160010944
onkologii29462160010951103147197220271324346368
prošla3341216001095283134171193238
v36062160010944
posledních367621600109531052140230001093657103155205226266316
letech247623000109216797142184234
hlubokou2729230001095072121173224266315365
transformací.3114230001093060104154189216266296372416456477496
Stala3630230001094573118139182
se394062001093681
integrální404462001092171101146197227271292342363
součástí443062001093686136177221256287308
onkologické4761620010950100143191213263315336377419463
léčby,524762001092167108160202217
neomezuje5486620010950963940760010949125171210260282328
se428676001093682
tedy438676001093075127170
pouze4575760010951102152191236
na483076001095093
podporu4942760010951102154205256286336
na529776001095093
konci540976001094291142183204
života.394090001093859101149178222240
Zaměřuje419590001094993167211239288309354
se456490001093580
kromě465990001094272120194239
fyzických491390001092671111132171212257296344
i5273900010920
na530890001095092
emocionální,54159000109451191683940104001094162112163207228279300319
psychologické4285104001095187131171222272294345396418459501546
a48571040010943
duchovní49261040010951101142192243286337358
potřeby53101040010952103133163208260303
pacientů3940118001095195136157203253283332
a42951180010944
jejich436211800109226789110151201
rodin.4586118001092979131152202221
Podobně4830118001094896148198250301346
jako5199118001092266108157
se5379118001093581
onkologie548311800109501003940132001094291113163214236281
v42441320010943
současnosti4310132001093686136177221257307356392423444
posouvá47771320010951102138188238282326
ke5126132001094286
stále5235132001093667111133178
větší5436132001094488118155176
personalizaci3940146001095197127163213264307328349388433473494
protinádorové4450146001095181130160181231274325375405454497541
léčby,5007146001092167108159201216
je5239146001092267
vhodné5322146001094394143195245290
přistupovat3940160001095282104140171222274326369414444
ve4410160001094489
stejném4525160001093667113135186232309
duchu48601600010951102143194244
k51301600010943
pacientům5199160001095196138159205257287337413
a39401740010944
jejich401017400109226991113155205
potřebám42421740010952103134164210263308385
i46531740010921
v47001740010944
rámci4770174001093075152194215
časné5011174001094186122173220
paliativní5257174001095297119141185216237282334356
péče,3940188001095299140185204
což4170188001094190129
může43241880010976126166212
nejen4561188001095197119166217
zlepšit4803188001093961107160196217248
zkušenost5077188001093982133168215266316352384
pacienta,54861880010952973940202001094163110162192238258
posilnit42242020010953105142164186237259290
vztah4541202001094486119165216
pacienta4784202001095298140161208260291336
a51472020010944
lékaře,5218202001092168112158189235254
ale5499202001094466113
také3940216001093076119164
přispět4130216001095283105141193241272
k44282160010943
efektivnější4497216001094674120164197219264316362385421443
a49662160010944
informovanější5036216001092273100151181259310353398449496519555576
spolupráci.3940230001093687138160209261291335375396415
LITERATURA341253001234978134189250318368438498567
1.34027000853648
Temel40127000833363121156172
JS,5862700083245669
Greer6682700083436599134156
JA,8372700083246478
Muzikansky92827000835492121137167201239265295329
A,127027000834155
et133827000833456
al.14072700083324760
Early14802700083336687102134
palliative16272700083397287102117149171186219253
care18932700083316485119
for3402800083185576
patients4292800083387092107141178199227
with6682800083506587125
metastatic80528000835791113145172194226248263294
non–small-cell111128000833875113149176232264279294316349382397412
lung15352800083155289128
cancer.167528000833163101132165186196
New188428000834478129
England34029000833370109125157195234
Journal58929000832463101122161193208
of81329000833756
Medicine.88429000835590130145177192230265277
2010;363(8):733-742.117629000833468100132145180214248266299318329363397430452483513546559
2.34030000853652
Ferrell4063000083326688109143159174
BR,5953000083357185
Temel69530000833263121156172
JS,8813000083245669
Temin96530000833263121136174
S,115330000833346
et121330000833456
al.12843000083324760
Integration13593000083145274108147168201223238276315
of168830000833857
palliative17593000083397287103117149171187219253
care3403100083316485119
into4723100083155374111
standard5963100083275083121160192213251
oncology86031000833876108145161199239271
care:11443100083316485119132
American128931000834199134155171203235273
Society157531000833371104119154176210
of179831000833756
Clinical186731000834056711081233403200083316479
Oncology43132000834786117154170208247279
clinical722320008331466199114145178193
practice9283200083385992124148163195228
guideline11693200083387590128163178193231265
update.144732000833776115147169202214
J1674320008324
Clin17113200083395469107
Oncol.183032000834785117154170182
2017;35(1):96-112.34033000833469101130140176209227259273285321356380411439469482
doi:8423300083397793105
10.1200/JCO.2016.70.1474.9683300083346679110140174210235256297343355391426458489502537570583614645678708721
Epub171033000833272110150
2016188033000833569101132
Oct34034000834780104
28.4593400083346881
PMID:55634000833589104150163
28034065.73434000833468103137172208244277289
3.34035000853549
Back4003500083356697125
AL,5363500083407083
Anderson62935000834077114147167193229266
WG,90635000835698110
Bunch102735000833571107138174
L,121235000833043
et126535000833454
al.13303500083314557
Communication139835000833974130186222258272302334354368404441
about184935000833269106143164
cancer3403600083316299130162182
near53336000833771101121
the6653600083215892
end76736000833471108
of88636000833755
life.95236000831528467991
Cancer.105336000834071108139171191200
2008;113(7126436000833467101135146175201230247280
Suppl):1897-1910.155536000833268106144158177187216246278310327357386416446458
doi:3403700083387589101
10.1002/cncr.23653.4523700083346476106136171203228256293324345354389423456489521532
PMID:99537000833588102147159
18798531;11653700083346496129163195227257265
PMCID:144137000833587127141185198
PMC3123252.165037000833587127161191220254285319351363
4.34038000853549
Stephens4003800083325284121158191228252
S.66338000833244
Hospital-based71738000834480105143157178209223244282313338371409
palliative1137380008338698397111141161175206239
care:13863800083316282114125
cost-effective15223800083316691113131166184202235266289303334366
care18993800083306281114
for3403900083185474
patients4253900083387090104137174194220
with6563900083506485122
advanced78839000833269100132168199231269
disease.10683900083375176109140165198209
J1288390008324
Nurs132239000834481100126
Adm.145939000834077133145
2008;38(3):143145.1615390008333661011341451792122292622772883163463773404000083346394105
doi:456400008338748899
10.1097/01.NNA.0000310724.20419.12.56640000833463751041341681992182502802883333764164294634985325675986286586897227527637988308658949229329619901001
PMID:157840000833586101145157
18327063.17454000083346396127158190224256268
5.34041000853650
Bakitas4114100083356899115137170197
MA,62841000835496110
Tosteson7584100083336793116150177215254
TD,10324100083327990
Li114241000833147
Z,120941000833751
et127941000833457
al.13564100083314760
Early14364100083326586102134
versus15904100083316687114151178
delayed17884100083387388120151185225
initiation340420008315526789104136158173210249
of60142000833757
concurrent67042000833168106138175196218252290311
palliative9944200083387186101116147169184216250
oncology125742000833775107144160197237268
care:15384200083316485119131
patient16824200083387192107142180201
outcomes1896420008337759734043000833168126161188
in54943000831452
the6224300083215994
ENABLE73743000833277118154186220
III9774300083153045
randomized10434300083205391130168227242271305345
controlled140843000833168106128149187203218253292
trial.1720430008322445991107119
J1860430008324
Clin19044300083405570108
Oncol.34044000834786118155171184
2015;33(13):1438-1445.53844000833468100130141176209227259289306318347378411445468499530567600612
doi:11644400083387692104
10.1200/JCO.2014.58.6362.12824400083356679109139173210234255296341353389423455486498534568581617650685718731
Epub34045000833372110149
201550445000833468100130
Mar65045000835487108
23.7734500083346981
PMID:87045000833589104150163
25800768;104845000833569104139175208240275287
PMCID:135045000833689130145191204
PMC4404422.156945000833589130162199235271308341376388
6.34046000853651
Chochinov40846000834077115147184198235273304
HM.73046000834498111
Dignity8584600083466199136150172205
and108046000833269108
the12054600083225993
essence13164600083346086120157189222
of155546000833756
medicine:162846000835792131145176191228262274
the19194600083225994
A,34047000834154
B,40847000833547
C,46947000834052
and53447000833270108
D655470008346
of71447000833756
dignity7844700083385290128142164197
conserving99447000833168105131165186220235272310
care.13184700083316384117129
BMJ.146047000833590115127
2007;335(7612):160047000833468103135144178211243260294325355384401412
184-187.34048000833566102125156187219225
doi:5854800083387792104
10.1136/bmj.39244.650926.47.7084800083356678109137167201226266325340352388421454486523535570604638673707740753788820825
PMID:155348000833589105151163
17656543;17364800083356496130164198233265276
PMCID:34049000833588128142187200
PMC1934489.55449000833588128159189221255292327361371
7.34050000853644
Epstein3955000083327096118150164201
RM,60750000833589102
Street7205000083325272105139161
RL89250000833566
Jr.9695000083244454
The103450000833270104
values11495000083316377114147173
and133350000833268106
value14505000083326378114148
of160950000833755
patient-centered167550000833870911051391761962152472803163405100083225779114154
care.5175100083326687122135
Ann67451000834281120
Fam81751000833363123
Med.96251000835692133146
2011;9(2):100-103.113051000833671103132140176196231249261292324361386418450484497
doi:16495100083397894106
10.1370/17785100083356780112142175209234
afm.1239.34052000833250108121151180214247257
PMID:61152000833588103148160
21403134;7855200083346595131163193223257268
PMCID:106752000833588128143188200
PMC3056855.128152000833588128163197230264298332364375
8.34053000853652
Wright4135300083587894133171193
AA,6275300083418499
Zhang74653000833876109147186
B,95353000833648
Ray102253000833568100
A,114253000834156
et121853000833457
al.12965300083314760
Associations13775300083416996134167182215237252290329356
between17535300083397597151186221260
end-of-life34054000833472111133173192213229244263298
discussions,6545400083385480112150176203217255294320333
patient10045400083387193108143181203
mental122354000835893131152185200
health,144054000833772104120142180193
medical164954000835893132147179212228
care18935400083316485119
near34055000833873104126
death,48355000833873105126165177
and67755000833270109
caregiver8045500083316485119158174206240262
bereavement10835500083387495129161193227285320358380
adjustment.14805500083327186124150173231266304326339
JAMA.183655000832464120162177
2008;300(14):1665-1673.34056000833468104139151185220256275306337354366396426462495517548579611645657
doi:10105600083387691103
10.1001/jama.300.14.1665.11265600083346577108139175206228244276333365378414448484496527557570600631666700712
PMID:185056000833589104149162
18840840;34057000833465101137173208245281293
PMCID:64957000833589129144190203
PMC2853806.86757000833689130165199233266300336371385
9.34058000853649
Saunders40258000833265103141180215236263
C.67858000834053
The74458000833372107
Management86458000835487125157196231288323361383
of126058000833756
Terminal13295800083336485143158196228244
Illness:1586580008314304582117144171183
First1782580008332476895119
published191458000833876340590008338546995132167206
by55959000833970
Hospital64159000834482109147163185218233
Medicine88759000835489128143175189227262
Publications116259000833571110126141173205227242280318344
London:1967:1-29.151959000833168106145183221233262292328360370400418449483493
https://doi.org/10.1093/acprof:oso/9780198570530.003.0016.340600008337588212114715918620624127929430634436540342846149250453456560063265668671875677781483384788491094897210061038107111061137116712011235126813001334136614001412144714831515152715621597162916591672
10.3406100085367085
Radbruch43961000833568107146168206238276
L,72961000833245
Ling7886100083314785124
J,92661000832436
Hegedus97661000834479118153193230257
K,124661000833550
et131061000833456
al.13806100083324760
European14546100083336990127167203234272
Association1740610008341699613416718221423525134062000833776
for4306200083195678
Palliative522620008336678398113145167182214249
Care:7856200083407394128141
forging9406200083195678116131169208
a1163620008331
vision1209620008332477388126165
of138862000833857
excellence14596200083346697131146161196234267300
in177462000831452
palliative184162000833972871021171493406300083223769104
Care4616300083407394128
in60663000831452
Central67563000834074112134155188203
and89563000833270109
Eastern10216300083336692116149170209
European12476300083336990128167203235273
and153763000833170109
former16636300083185677136171192
Soviet18726300083327110311834064000833456
Union4136400083448297135173
countries.60364000833268107145166188203238265278
Journal89864000832463101122161193208
of112364000833857
pain11976400083387187124
and133964000833169108
symptom146464000832659118157179216274
management.17556400083579012816019923434065000835792130152165
2018;55(2):S117-S120.52165000833468100131143178211228262280292326356384413432463494524558571
11.3406600085356576
Lupu42866000833167105142
D.58266000834556
Dale.6506600083447690124136
American79866000834097131152167198230267
Academy107766000834071103141175231261
of135066000833755
Hospice141766000834481107145160191224
and165366000833168106
Palliative1771660008335668195109140162176208241
Medicine34067000835490129144176191229264
Workforce61967000835794115146167205226258291
Task9256700083326087117
Force.10576700083326991122156168
Estimate1239670008333618499157189211245
of149867000833857
current15706700083316990111146184205
hospice179067000833776102141157189223
and34068000833269108
palliative4616800083397187102116148170185217251
medicine72568000835792131146178193231266
physician100368000833977108134149181196228265
workforce128168000835188110140161198220251284
shortage.157868000832664102123148180219254266
J1857680008324
Pain18936800083356782120
Symptom34069000833363122161184221280
Manage.64069000835588126159198233246
2010;40(6):899-911.90669000833569101133146181217237270289301336371406430465498525535
doi:14626900083387692104
10.1016/j.jpainsymman.2010.07.004.1587690008334667911014217420523024726027631634936440334070000832659117175207245259295329361392405440472478514550586598
PMID:95470000833589104150163
21145468.11327000083356694125158193229264278
12.3407100085366883
World43671000835794115131170
Health61971000834479110126148186
Organization.81871000834769107139177192221254276291329367381
National12117100083457799114152190223238
Cancer146271000834073110143176197
Control167271000834077115137158195211
Programmes:189671000833556933407200083385991148205240266279
Policies6317200083357187101133148182208
and85272000833169107
Managerial97272000835486123155194228249264296311
Guidelines12957200083448196134169184199236271297
(2nd160572000831851165672000492244
ed.).17137200083347386103114
Geneva:1840720008343781161503407300083326577
World43273000835894116131170
Health61873000834479111126148187
Organization;82073000834769107139177192221255277292330368380
2002.121573000833569105138150
13.3407400085366883
NCCN44074000834586124169
[online].6257400083195593109124162197214226
[Accessed8677400083195890121154181208243282
91166740008334
March121774000835487108139177
2024].141174000833468101133151163
Available159174000834171104119135167206222257
from:18647400083194178136149
https://www.nccn.org/professionals/physician_gls/pdf/palliative.pdf.34075000833758811201461581842042543063583694074384685055185555766136396756967337517858118378518889269579729971022105910971127115311671198121312441281131713561370139614211457149615151538157516071622163616513407600083325469101136148188227247258
14.21402700085366984
ESMO.223727000833366120168180
ESMO242927000833367121168
clinical2610270008331476199114146179194
practice28172700083386092124148164195229
guidelines:30592700083387590129164179194232266293306
Supportive337727000833370109148187208233248280314
and370427000833270109
palliative21402800083397187102116148170185218252
care.24042800083326485119131
ESMO254828000833366121168
[online].27292800083195593108123161196213224
[Accessed29662800083195889120154180207242281
93260280008334
March330728000835486107138176
2024].349628000833468101132151162
Available36712800083417210411921402900083154685100134
from:22872900083183976133145
https://www.esmo.org/guidelines/guidelines-by-2444290008337588212114715918520525530836037140543148852553757559663365969473174578381883384788591994597010051042105710951129114411591196123012571277131613471368
-topic/supportive-and-palliative-care.214030000832143801201351671942192562953353743954204354685025255575956346576977307457607758078298448779119349681001102210561068
15.21403100085366883
Česká223631000834073100130163
společnost241231000832665104120154187225263289312
paliativní27373100083397287102134155171203242257
medicíny300631000835893132147179194232262
ČLS328131000834071106
JEP.3399310008324589398
Česká351031000834073100130163
společnost36863100083266510321403200083154981118156182205
paliativní23583200083387085100131153168200238253
medicíny262332000835791130145177191229259
[online].28943200083195492107122159194210222
[Accessed31283200083195889119152179205239278
93419320008333
March346532000835486107137175
2024].365232000833467100131149161
Available214033000834171104120135167206222257
from:24123300083194178136148
https://www.paliativnimedicina.cz/.2576330008337598312314916218920926031336737841845146648151353555058262163669472976978481683186990191494697710051011
16.21403400085356781
Fórum22323400083326787124179
mobilních242234000835693130145158194208238274
hospiců27073400083377398135149180216
[online].29333400083185389103117153186202212
[Accessed31563400083185685115147172197230268
93434340008334
March347834000835484104133170
2024].36583400083346697127144155
Available214035000834171103117132163202217251
from:24053500083194077134146
https://www.mobilnihospice.cz/.25653500083375882120146158184204254307360370428465504519533571585622660686724739770803815846876903908
17.21403600085366775
Ferrell22303600083326686107141156170
BR,24153600083357184
Temel251436000833363120154169
JS,26983600083255668
Temin278136000833363120134171
S,296736000833345
et302736000833456
al.30983600083324658
Integration31713600083155373106145166198219234271309
of349536000833756
palliative35663600083387185100114145166181213246
care21403700083316384117
into22743700083155273109
standard24003700083264880118156188208246
oncology266237000833875107143158196234266
care:29453700083316383117129
American309037000834199133154168200232269
Society337637000833370102117151172205
of359837000833756
Clinical3671370008339546810512021403800083316378
Oncology223338000834785116153168205244275
clinical2523380008332466098112143175190
practice27283800083396092123147161193226
guideline29683800083397590128162177191229263
update.324638000833775114146167200212
J3472380008325
Clin35113800083405569106
Oncol.363238000834785117153168180
2017;35(1):96-112.21403900083346797125134168200216247260271305339361391418446458
doi:26093900083387489100
10.1200/JCO.2016.70.1474.27203900083346476105134167202225245284328339374407437467479512544556585615646675687
Epub341839000833270107144
201635743900083336697127
Oct371239000834678101
28.21404000083346780
PMID:223440000833588103148160
28034065.240840000833467102134169204239272284
18.21404100085366985
372/2011224041000833466101127162196228256
Sb.25114100083327184
Zákon261041000833770100138176
O2801410008347
zdravotních28634100083296788121153190212250265297335
službách.32134100083264279108148181213251264
Zákony349241000833871101139177208
pro37154100083386097
lidi2140420008315306883
[online].22364200083195493108123160195212224
[Accessed24734200083185789119153179206241280
92766420008334
March281342000835486107138176
2024].300242000833468100132150162
Available317742000834071103118133165204220255
from:34454200083184077135147
https://36054200083375983122148161187208
www.zakonyprolidi.cz/cs/2011-372.2140430008351104157168199232263300339369409431468484499538553566598628656685713739774808839867886918950985997
19.21404400085366982
Liu22414400083314784
X,234444000833851
Dawod241444000834577128166205
Y,263844000833543
Wonnaparhown269944000835894133171203242275296335373424463
A,318044000834155
et325444000833356
al.33284400083324760
Effects34074400083325170105137161189
of361544000833756
hospital36894400083387610321404500083395477109125
palliative22844500083397287102117149171186219253
care25574500083316485119
on269545000833876
health,279145000833772104119142180193
length30034500083155088127150188
of321045000833757
stay,32864500083264982113123
and342845000833270109
in-hospital3557450008314527511415217921723321404600083225470
mortality222946000835795117142174190205227261
across25094600083326485122149175
intensive27034600083155374108146173187220254
and297646000833270109
non-intensive-care310446000833776114136153190212246284310325358392415449481503537
units:36604600083377590112140152
A2140470008341
systematic21974700083265986109143201233255270302
review25154700083215587103138189
and272047000833270109
metaanalysis.284547000835793115148180218250266297324339365379
Palliat3240470008335678298113144166
Support342247000833370109149188209234
Care.36724700083407394128141
2017;15(6):741-752.214048000833571104135145177208227261280293328359391411443478512526
doi:26874800083397996108
10.1017/S1478951516001164.28174800083356882114146180210231266298330364398434470502534566598635673706735768806819
Epub365848000833374114154
2017214049000833468100129
Feb228549000833266105
15.24064900083346476
PMID:249749000833589105150163
20.21405000085367287
Hui22415000083448297
D,235250000834556
Kim242250000833551109
YJ,25445000083365669
Park26265000083356788119
JC,27595000083246578
,2851500008312
et287750000833356
al.29475000083314760
Integration30205000083155375108148169202224239277316
of334950000833857
oncology342050000833775108144160198238270
and370450000833270109
palliative21405100083387186100115146168183214248
care:24015100083306383117129
a2542510008332
systematic25865100083265885107140198229251265297
review.28955100083215486101135186196
The310451000833270105
oncologist2014-0312.322151000833775106143158196235249275298333366397428450487520550579591
Epub214052000833372110149
2014230452000833468100131
Dec245152000834580113
5.257952000833446
PMID:264152000833589104150163
25480826;281952000833469104140176211245278291
PMCID:312552000833589129144190203
PMC4294615.334452000833588129162194228264300331361373
21.21405300085367083
Zimmermann224453000833854112170206227286319357396
C,266153000834053
Swami273553000833283116174190
N,294653000834558
Krzyzanowska30245300083365889124155189227266317345375409
M,345453000835568
et354353000833457
al.36215300083324760
Perceptions37025300083366991214054000833165105127143181220246
of240754000833757
palliative24845400083397388103119151173188221256
care27605400083326586120
among290154000833290129168207
patients31295400083397294109144183204232
with33825400083516689128
advanced353054000833272105138176208242282
cancer214055000833165103136170191
and235255000833270110
their24825500083226196111133
caregivers.26355500083326586121161176209244265293307
CMAJ.296255000834096138166178
2016;188(10):E217-E227.316155000833569101133145175207243262294326344356390426458487506541577612645651
doi:21405600083387692104
10.1503/cmaj.151171.22585600083356679109139174207231260318350365378409439470498527560569
Epub284256000833271109149
2016300556000833469100131
Apr315156000834180102
18.32685600083346578
PMID:336156000833589104150163
27091801;353956000833467100135167198233265273
PMCID:214057000833589129144190203
PMC4938707.235957000833588129162195228262295328361367
22.21405800085367288
Centeno224758000834074112133167205243
C,250958000834053
Garralda25815800083447798120153168207239
E,283958000833346
Carrasco29045800083407394116149175208244
JM,31675800083258093
et327958000833456
al.33545800083324860
The343358000833372107
palliative35595800083397287102117149171186219253
care21405900083316485119
challenge:227759000833169101117132167205244279291
analysis258659000833270102117149176191217
of282159000833756
barriers28955900083387192114130165186213
and312659000833169108
opportunities325259000833777116155177201239277292315330365392
to366159000832259
integrate37375900083155321406000083225595116149170204
palliative23576000083397287102117149170186218252
care26226000083316485119
in275460000831553
Europe28206000083326990127166202
in303560000831552
the31006000083226095
view32086000083314782133
of335460000833756
national34236000083387092107145183215231
associations.3667600008331588412221406100083324780103119158197224238
J2400610008324
Palliat24466100083356884100115148171
Med.263861000835591132146
2017;20(11):1195-1204.280561000833570102133143179214234267295310323353382413448471502533568605618
doi:34456100083387894106
10.1089/35726100083356881112145181216240
jpm.2017.0039.214062000831554112126162196228257263298334367401412
Epub256762000833372110149
2017273162000833468100130
May287662000835487118
16.30096200083346579
PMID:310362000833589104150163
28509657.328262000833467101136171206240273279
23.21406300085367287
Vranceanu22416300083365689127159193225263300
AM,255563000834196110
Cooper267863000834077115155191212
C,290363000834053
Ring29696300083365189128
D.311063000834657
Integrating31806300083155375108148169202224239277316
patient35096300083397294109144182203
values37266300083316421406400083155286113
into22666400083145273110
evidence-based23886400083346682120155193224258281320353379414453
practice:28546400083386092124148163195228240
effective31076400083345372106138162177210244
communication336364000833168126183220258273305337359374411449
for21406500083185678
shared22336500083266496118152191
decision-making.244065000833873106121147162200238260319351382398436475488
Hand294465000834476114153
Clin.31136500083405570108121
2009;25(1):83-96,325065000833468104139152187222240271286298332366388423459471
vii.3737650008332476275
doi:21406600083387692104
10.1016/j.hcl.2008.09.003.22596600083346678109141172203229245258297329344357393427463499512547582593628665698710
PMID:298466000833689105151164
19232919.31636600083346497132165199231261272
24.21406700085367186
Sochor224067000833271103141180201
M,245567000835568
Sláma25376700083324880138170
O,272167000834758
Loučka279367000833168106138168202
M.300967000835468
Časná30916700083407399137169
integrace32746700083155374108147169202234267
paliativní35556700083397287102134156171204243258
péče214068000833872104136
do228868000833875
standardní23746800083264880117155186206243280295
onkologické268068000833774103140155192230245276305338
péče303068000833772103136
–3178680008334
benefit,322468000833872109143160177198211
limitace,3447680008314288599121152183216227
bariéry3686680008338709010521406900083345488
a2240690008332
druhy22846900083385996134164
paliativní24606900083397186101132153168200239253
péče272669000833873105138
[Early28766900083195284105120152
Integration30406900083155273106145166198220235272310
of336269000833756
Palliative3430690008335678296111142164179211244
Care36876900083397292126
into21407000083155374111
Standard22657000083325386124163195216255
Oncology253370000834786118155171209249281
Care28277000083407394128
-2969700008321
Benefits,300670000833671109144161178201228241
Limitations,326170000833147105120142175197212250288315328
Barriers36027000083366990112127162183210
and214071000833270109
Types226971000833361101136163
of245371000833756
Palliative2530710008335678297112144166181214248
Care].27997100083407394128145157
Klin29777100083345166104
Onkol.310171000834786116154170183
2015;28(3):171-176.330471000833469100130141176210229263280292322351384403433463495508
Czech.214072000834071105137175188
doi:23447200083387692104
10.14735/amko2015171.24637200083346678109140172206239263293351381419452486518548579608641650
PMID:312872000833589105150164
26062618.330772000833468103139172206236267281
25.21407300085377490
Berns22517300083367294134162
A,243473000834257
Ringborg25127300083365392132172212235274
U,280873000834456
Celis28857300083417692108135
JE,30417300083255973
et313673000833457
al.32157300083324862
Towards329873000833469121155177217244
a3563730008333
cancer361773000833266105139173195
mission21407400083587399126141179218
in237874000831553
Horizon245274000834483104120149187226
Europe:26987400083337091129168204217
recommendations.29357400083215588125184242278316355388410425463502528542
Mol349874000835493109
Oncol.362874000834786118155171184
2020;14(8):1589-1615.214075000833570104140153185217237272291303334366401437461493525557588601
doi:27627500083397995108
10.1002/1878-0261.12763.28917500083356881113146183217245279311346380404442476511543553585616650683718731
PMID:364475000833691107155168
32749074;214076000833467100130163199232262274
PMCID:242976000833589130145190203
PMC7400777.264876000833589129164195231267299334368375
26.39402700085366983
Česká40332700083407196125156
onkologická419927000833773102137151188225239269297329
společnost453727000832663100114147178214251275297
ČLS484427000833969101
JEP.4955270008324558992
Modrá505727000835490128147179
kniha52452700083306780116147
[online].54022700083185289102116152185200210
[Accessed39402800083185686115147172197230268
15421728000833463
September428928000833366103124156211249283302
2023].46012800083346697130146156
Available476728000834069100114127158195209242
from:50192800083183974131141
https://www.linkos.cz/lekar-a-multidisciplinarni-tym/personalizovana-onkologie/modra-kniha-cos/aktualni-vydani-modre-knihy/.517028000833757801171421531781972462973493583733864223940290008329659010213316218820323626429631633436538544247849251352756457760263264668369871174777879783484886888992197810031038107210921118115411911222123512491276131213421373141014401461149915361564160016141651394030000833852851101652022402602913123423803934304614825145505755996286576807177487627988128328648979349641001101510351093113011681188122012421272131013231360138914111415
27.39403100085367180
Mordt403431000835493114153175
D,422431000834556
Lansdown429431000833265103129169207258296
M,460531000835468
Smith468731000833390105128166
N,486731000834558
et493931000833457
al.50103100083324760
For50853100083326991
better,51913100083387496120154175185
for53913100083185677
worse?54833100083508811039403200083266186
a4041320008331
review40873200083215587103138189
of429132000833756
the43623200083216095
care44713200083326486120
of460532000833857
patients46773200083387193108143181203230
who492232000835189128
died50643200083385388128
within52063200083516789127142180
30540132000833469
days548432000833871102129
of394033000833756
receiving40093300083205486120135167183220259
systemic42803300083265985108142199214246
anti-cancer45383300083327091106128161194232263297318
therapy.48683300083226094115148187218228
The510833000833372106
National52273300083447698113151189221236
Confidential54763300083397611439403400083173473108146167183215230
Enquiry418534000833371110147162184218
into44183400083155274111
Patient45443400083356789104139177199
Outcome475834000834785108139176234269
and504234000833270109
Death.516634000834681113135173186
2008.536734000833569105140154
28.39403500085367288
Nguyen404435000834584121153188226
M,428635000835568
Sean437035000833368100138
Ng452435000834484
YK,46243500083357186
Shum472635000833370108166
E,490835000833346
et497035000833456
al.50423500083324861
Anticancer511935000834179100116148181219251284306
therapy54413500083226095116149394036000833970
within40283600083516689127142180
the42263600083226095
last4339360008315487497
30445536000833468
days454236000833870101128
of468836000833757
life:476336000831530498496
results48773600083215582119134157185
of508036000833756
an515536000833270
audit524336000833269108123146
and540736000833270109
re-55343600083215578
-audit39403700083215391130145167
cycle41233700083316596112146
from42853700083184078136
an443737000833169
Australian452237000834178104127149182197212244282
regional48203700083205594109147186218233
cancer506937000833164102134168189
centre.527437000833165103124146180192
BMC548237000833590131
palliative39403800083397287102117149171186219253
care.42083800083316485120132
2020;19(1):1-10.435538000833468101135148178208228259274286315334365396409
29.39403900085367285
Hodi404239000834482122137
FS,41953900083336577
O´Day428939000834765111143174
SJ,44793900083335769
McDermott456539000835486132167189247285307332
DF,49133900083457984
et501439000833456
al.50863900083324860
Improved516339000831572112133170202237276
survival5455390008327648512013539404000083326682
with40444000083516791130
ipilimumab4195400008315557287103162201260294334
in455040000831554
patients46254000083407496112148187210238
with48844000083526891131
metastatic503640000835995118152179203237259275308
melanoma.536540000835995111144184223394041000835790103
N4058410008345
Eng411841000833371110
J4243410008324
Med.428341000835489129142
2010;363(8):711-723.444041000833468100132144179214248266299317329363395423442473507542554
30.39404200085367186
Larkin40384200083316485115130168
J,421842000832436
Chiarion-Sileni42664200083397791123143158196234255286301315350387402
V,468042000833544
Gonzalez473642000834381119148181196230259
J,500742000832436
et505542000833455
al.51234200083314659
Five-year51944200083324678112135166199231251
survival5458420008326628311713239404300083326580
with40344300083516789127
combined417643000833168126165181219254293
nivolumab44844300083375285122138176234266305
and480443000833170109
ipilimumab4927430008315546985100157195253285324
in526643000831452
advanced533343000833171103136174206240280
melanoma.394044000835792108140178217275307320
N4276440008344
Eng433644000833270109
J4460440008325
Med.450044000835490129142
2019;381(16):1535-1546.465844000833468100130143178212244259291322340352382412445478500530560596632645
31.39404500085366880
SVOD403345000833269115160
Analýza420645000834078110125156186219
[online].44374500083195492107122159193210222
[Accessed46714500083185788118151178204238277
28496145000833367
February504045000833265104125163194215249
2024].530145000833467100131149160
Available54744500083407010311739404600083154786102137
from40924600083194178136
https://www.svod.cz/.42444600083375983122149162189209260313367378405438476515528560591619625
32.39404700085367186
Bluethmann40444700083355189123146184242274312350
SM,441147000833387101
Mariotto452947000835487108123161183208245
AB,47914700083417789
Rowland489747000833674125141173211250
JH.51644700083246983
Anticipating526447000834179100116148163202235257272310349
the39404800083226095
„Silver4055480008321546984117151172
Tsunami“:42484800083325491129162219235256267
Prevalence45354800083355690122155171206244276310
Trajectories4865480008332508398133165190227248264298325
and521148000833169108
Comorbidity53404800083407713517319523525039404900083395477112
Burden40734900083357496134170209
among430349000833291130169209
Older453349000834864104139161
Cancer471549000834174113146180202
Survivors49384900083337192128144177215237265
in522449000831554
the52994900083226196
United54164900083458399122156196
States.39405000083335487109143169183
Cancer414450000834073111143177198
Epidemiol43635000083337287126162220235273289
Biomarkers46735000083355089147180201232266287315
Prev.50085000083365691123133
2016;25(7):10291036.516250000833468100131144179214232266286298328360393427394051000833567101136149
doi:41115100083387793105
10.1158/1055-9965.EPI-16-0133.42375100083356780112140171206231265297332365388424460496530543578613628652683715739777809840874886
PMID:514451000833691107153167
27371756;533251000833568103136169199233268280
PMCID:394052000833589129144190203
PMC4933329.415952000833588129162195228261294326360371
33.39405300085367186
Vokurka404353000833672102140162192226
S,428653000833245
Rusonová43485300083357399138176214246279
K,464453000833550
Sláma47115300083334880138170
O,489853000834758
et497353000833457
al.50475300083324760
Jak51245300083245686
je522753000831550
vnímán52945300083327186143176214
význam55255300083326639405400083286799157
paliativní41135400083397287102134156171204243258
péče438754000833974107140
a4544540008332
spolupráce459254000832665104120157196218251283317
s4925540008326
paliatry49685400083387187102134156177211
z5195540008329
pohledu524054000833978116131166206243
českých5500540008331659139405500083306495133
onkologů?408855000833876106144160198237275299
Paliativní4402550008335678297129151166199238253
medicína.467055000835792132147179194232264278
2024;5(4):1-5.496355000833468101133145180198231248260290308342354
34.39405600085367287
Petrillo40455600083356889110125140154191
LA,42545600083327488
Jones435956000832562100134160
KF,45375600083356873
El-Jawahri4628560008333476989121171203240261276
A,492156000834155
et499456000833455
al.50675600083324659
Why514356000835896126
and528756000833169107
how541256000833775125
to555556000832258
integrate39405700083155273106145165197218251
early42075700083346585100131
Palliative4354570008335668195109141162176208242
Care46115700083407293126
into47525700083155273109
cutting-Edge48775700083316890113128165203225259296334369
Personalized52615700083356888115152190222236251279312351
Cancer394058000833970107137169189
Care.41405800083397090122133
Am428358000834197
Soc439058000833269100
Clin45005800083395367103
Oncol461458000834683113148163
Educ478758000833369105135
Book.493358000833571108137151
2024;44(3):e100038.50945800083346697128138171206224256272283315344373408442474506519
doi:39405900083387690102
10.1200/EDBK_100038.40565900083346576106136169205228261306342377415446477512547580614626
PMID:469659000833588103148161
38815187.487159000833467102133163193223256261
35.39406000085367084
Ministerstvo403760000835469106121146169202223250272306343
zdravotnictví43926000083286687119150187208246261292316349365
České47696000083407399128162
republiky.49436000083215493130169184199228262271
Pilotní52276000083344963101122160175
projekt54146000083385996111145175199
paliativní39406100083397287102134156171204242257
péče421761000833975107141
v4378610008331
nemocnicích442961000833873131169202240255287302334372
přinesl48216100083386075113148175190
základy50316100083286292109141180212
pro52636100083386097
standardizaci5380610008326498212015919221339406200083385382116148163
a4120620008332
rozvoj41696200083215886121159174
paliativní43616200083387187102133155171203242257
péče463562000833974107140
v4793620008331
ČR484262000834075
[online].49346200083195593109124162197214226
Praha:51776200083355689127159171
Ministerstvo53666200083547010812314917220622739406300083264984121
zdravotnictví40796300083286687120152190211250265297321355371
ČR,44686300083397589
2023457563000833468101135
[cit.4728630008319496486100
14.48456300083346578
4.494063000833547
2025].500563000833468101136155167
Available519063000834171104119134167206222257
from:54646300083194178136148
https://mzd.gov.cz/tiskove-centrum-mz/pilotni-projekt-paliativni-pece-v-nemocnicich-prinesl-zaklady-pro-standardizaci-a-rozvoj-paliativni-pece-v-cr/.39406400083375983122149161188208264293331344383421453462494525553575590616646683715749772805839877898919957101510371096112511531190120512211258128013181333135513951417145414691504153415581578161716503940650008315306283981311691842062462823143483714034254644995565956276656807127277597968198598808969339689951010103210591092112211391171121012411263130313251362138514121435146715051544157615971635165039406600083286294109131163186208245273308346361383423456472487519540556588627642664704740772806829862884917939962968
36.39406700085377592
Stiefel40566700083335672109129165182
F,426267000833340
Bourquin432667000833676116138178218234274
C,462367000834256
Salmon47026700083346885145185225
P,495167000833642
et501767000833558
al.50996700083334963
Communication518667000834180141201240280296330364387404394068000833776
and403668000833270109
support416568000832764103143182203228
of441368000833757
patients44906800083397294109144182203231
and474268000833169108
caregivers48716800083316485119159174207241262289
in518168000831452
chronic52546800083316990127166181213
caner548768000833265103394069000833558
care:40266900083326789125139
ESMO419369000833369126176
Clinical43976900083415874114131164199216
Practice46416900083365893127153170204239
Guideline490869000834585102143179196213253290
ESMO522669000833369126176
Open.543069000834890128168182
2024;9(7):103496.394070000833469102134146182201236256268298330363399432468482
doi:44427000083397793105
10.1016/j.esmoop.2024.103496.45687000083346678110141173205230247260295322380419458498510547581614646659690722755791824860874
Epub546270000833372111150
2024394071000833468101133
Jun408871000832462100
18.42047100083346578
PMID:429871000833588104150163
39089769;447671000833468103139173206238272285
PMCID:477671000833589129144190203
PMC11360426.499471000833689130162190220254290326358392405
37.39407200085367181
Kroschinsky40427200083355896123156195210249276306341
F,440472000833339
Stölzel44647200083335492108138172188
F,467372000833339
von473372000833271110
Bonin486472000833575114129168
S,505372000833346
et512072000833457
al.51987200083324861
New528072000834581133
drugs,54347200083396099139165179
new394073000833873124
toxicities:40837300083225989105137152174189224251264
severe43667300083266193128149183
side45697300083264179114
effects47037300083345372107140164191
of491473000833756
modern499073000835796135170191230
targeted52407300083215475113148171204244
and550373000833270109
immunotherapy394074000831572130167205243265303338359392431462
of441574000833756
cancer448474000833164102134167188
and468574000833270109
their48077400083215994109130
management.495074000835789127159198233291326364385398
Crit5361740008340617699
Care.54737400083397293127139
2017;21(1):89.39407500083346798127137171202216248262273307341351
doi:43047500083377590102
10.1186/s13054-017-1678-1.44187500083346577107134165199224248277306340374408431467499527545576606639671693724733
PMID:516375000833588103148160
28407743;533675000833467102138170204233265276
PMCID:394076000833589129144190203
PMC5391608.415976000833588129165198231263294330365378