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Onkologie.9168040010761110147195214263313331375390
2025;19(4):214-2181326804001074487128172185223260284326347362406446485513552592631
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PŘEHLEDOVÉ341200012660124182256312369444520587645
ČLÁNKY1008200012660115187259327395
Durvalumab34136001063778114152189220259313354389
v746360010636
léčbě7983600106296196132164
limitovaného97836001062947100118150189226263304335377417
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SCLC16233600106316697130
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na175876001095095
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parametrů1806900010952981291762140620010976123155186238
OS2405620010963108
a2541620010944
PFS,261362001094892137158
kterých279862001094377123154202243294
bylo312062001095295119170
dosaženo3318620010951103140186227273325377
ve372362001094389
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výrazný320876001094388118161200250291
příznivý351476001095180101140189210253299
„skok“214090001093269112161205240
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léčbě,245990001092168110162209228
proto270590001095182132163212
lze293590001092161107
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durvalumabu5091620010951102132180224247297373418470522
po3940760010951103
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chemoradioterapie454676001094191138215266296341394416466497543574619671694740
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LD-SCLC.4382900010942103135179232275326348
LITERATURA341113001234978134189250318368438498567
1.34013000853749
Rudin41113000833675114130169
CM,60113000834197111
Brambilla7331300083365892151191207223238271
E,102613000833346
Faivre-Finn10941300083326378112134169193228243282321
C,143613000834154
Sage151113000833367107143
J.167513000832437
Small-cell173413000833391124140156179213248264279
lung3401400083155392132
cancer.49314000833165104136171192203
Nat71714000834578101
Rev83914000833571104
Dis9641400083466288
Primers.10731400083365773132168189217231
2021;7(1):3.132514000833569103135144177194226241253289302
doi:16481400083397793106
10.1038/17751400083346679111143177212237
s41572-020-00235-0.3401500083266292122156190211248281315339376412445479512535572584
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Kim42716000833654115
SY,5741600083337281
Park6871600083367194126
HS,8451600083468095
Chiang9721600083418198132172214
AC.12181600083428499
Small134916000833393128145162
Cell15431600083417794111
Lung168616000833372112154
Cancer:1872160008341761163401700083326789104
A466170008342
Review.52917000833773107123159212224
JAMA.77517000832466123167183
2025;333(21):1906-1917.97917000833571105141153189223258277312345360373404435472509534566598631662668
doi:10.1001/16691700083397995108139172185217250288321343
jama.2025.0560.34018000831547105137151187221254288300335370404439452
3.34019000853651
Jett4101900083245981106
JR,5351900083246074
Schild62819000833264102117133172
SE,8181900083336578
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KA,11011900083357993
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small175219000832683116131146
cell1917190008331658196
lung3402000083155290129
cancer:48420000833164102134168189203
Diagnosis7012000083456193132170208235250276
and99120000833270109
management111520000835789127160199234292327365386
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lung15872000083145290129
cancer,173020000833264103135168190199
3rd1944200008334197820000491234
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American44721000834199134156171204237275
College7422100083407894109144184219
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Chest105921000834078113140163
Physicians124321000833573103131146178193225263290
evidence-based15532100083346783122157195228261285325358385420460
clinicla340220008331476299114146162194
practice5542200083396194126150165197231
guidelines.8052200083387691130165180195233268295309
Chest.113422000834078113140163176
2013;143(5133122000833468100130141171202235253286
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-e250S.3402300083215792127161193207
doi:5622300083387692104
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PMID:131523000833589105150163
23649440.149423000833469103140173209246282294
4.34024000853651
Kalemkerian4042400083356884118176206240261277308346
GP,7632400083447984
Gadgeel86024000834376115154188224239
SM.111224000833286100
Modern122524000835593132167188226
staging14642400083264982121136174212
of168924000833757
small175924000832683115130145
cell1917240008331658095
lung3402500083155290129
cancer.48425000833264102135168189200
J699250008324
Natl7382500083447799114
Compr86725000834077135174196
Canc107825000834073111143
Netw.123625000834479102155166
2013;11(1):99-104.141625000833569101130142172200215246261273308343367398429465478
doi:19092500083387691103
10.6004/jnccn.2013.0012.3402600083346678113149185221246263301333364402415451485517547559594630662692705
PMID:106026000833589104150163
23307985.123826000833569102137169203238272284
5.34027000853650
Toh40327000833266105
TS,5212700083326678
Lok6122700083316999
BH.7242700083358093
Limited-Stage83027000833147104119142175215237268289322361395
Small-Cell123827000833390122137152175217251266281
Lung153227000833168106145
Cancer:169027000834073110142176197211
Current1914270008339763402800083214276114135
Progress4882800083355693132153187214240
and74128000833270108
the8622800083226095
Next97028000834479110134
Frontier.11172800083335289127149164199220230
Radiation.136028000833568106121153175190228266279
2021;1(4):317333.16522800083346810113214017018521823524728231334234029000833467100113
https://doi.org/10.3390/radiation1040026.4682900083375983123149162189209245283298312350371409435469500513548581614650675694727766781813835850888927957988102410601096112911631176
6.34030000853652
Uprety40730000834483104138161194
D,61630000834657
Seaton6883000083326799121158196
R,89930000833649
Niroula9643000083445981118156171203
A,118230000834156
et125330000833456
al.13243000083324760
Trends13993000083335084122161187
in160130000831553
the16693000083226095
Incidence1779300008315528510013917321234031000833165
and42331000833270109
Survival5503100083337091126142174207223
Outcomes79131000834786108139176234269296
in110531000831553
Patients11763100083356789104139177198226
With14203100083587496135
Small157331000833290122138153
Cell17443100083407489105
Lung186731000833168106145
Cancer34032000834073111143177198
in55232000831452
the6183200083216095
United7263200083448297119153193
States:9323200083335487109142169182
An112732000834179
Analysis122032000834179112127159186201227
of146032000833857
the15313200083216095
SEER16393200083336598133
Database.178632000834577991321712043403300083266173
Cancer42633000833972110142175196
Med.63533000835589129142
2025;14(3):e70608.79033000833467100135145175206226259276288322354387423458493507
doi:13093300083387692104
10.1002/cam4.70608.14253300083356678109140176209235264296354389401435468504539574588
PMID:34034000833589104150163
39908169;51934000833467102138173205236270283
PMCID:81834000833588129144190203
PMC11797299.103634000833589130162189219252285319353389400
7.34035000853645
Krejčí4033500083355791107139153
D,57435000834556
Mužík64835000835492121137168
J,83435000832436
Dušek88835000834583109144175
L.108035000833145
Novotvary114335000834483115152174209242263297
2019–2021145735000833469100131168200234267298
ČR.17733500083397590
Cancer1880350008340731113403600083316586
incidence4413600083155385100139174212244278
2019–202173436000833468100130168199234266298
in104736000831553
the11153600083226095
Czech122536000834071105137175
Republic.141636000833570109147187202217249263
[cited1694360008319496486120159
20.18693600083346881
8.196536000833447
2025]34037000833468101136156
Available51037000834171104119134167206222257
from:7813700083184078136148
https://www.uzis.cz/res/f/008447/novotvary2019-2021.pdf.9433700083385984123150162189209261314367378416445461487500532563591610644671697716741774811846882919951971100810463403800083326991125158180214245279311341365396430463494503543583602614
8.34039000853551
Mathieu40339000835485106144158192229
L,64439000833144
Shah70039000833268100137
S,84939000833244
Pai-Scherf9053900083356680102132164201235256276
L,119339000833144
et124939000833455
al.13163900083324659
FDA138739000833276114
Approval151339000834179118138175206238253
Summary:1778390008332681251812133404000083215568
Atezolizumab4224000083406295125162178193222260318351390
and82540000833270109
Durvalumab94740000834684105140173188226283316355
in131540000831553
Combination138140000834077135174190228260282297335374
with17684000083516689127
Platinum-Based190840000833550823404100083223776114172195232266292328368
Chemotherapy72841000834179114173212234272308329362402434
in118241000831553
Extensive12564100083336691125163190205238272
Stage15494100083335487127162
Small173241000833391123139154
Cell19074100083407490105
Lung34042000833269108147
Cancer.50842000834073112144178200210
Oncologist.73942000834787119156173211251266293316330
2021;26(5):433-438.109042000833469102134142177211231265283295330363397419456489523537
doi:16484200083387793105
10.1002/17744200083346679110142178211238
onco.13752.214013000833776108145157188218250283316328
9.214014000853751
Lim221414000833249109
JU,23451400083257183
Ryu245014000833670111
WK,258314000835997112
Park27171400083367092124
N,286314000834660
et294514000833559
al.30261400083334963
Current311114000834179101124160200222
and335514000833373114
future34911400083195983122144180
perspectives369314000834077100214015000832767104138163179212248276
in243715000831554
extensive-stage25131500083346792127167194210243279303331355389429465
small-cell300015000832686119135151174209244260276
lung32971500083165494134
cancer.345215000833266106139174196207
Ther368015000833474110133
Adv214016000834281114
Med227516000835691132
Oncol.242816000834787120158174187
2025;17:17588359251326705.263616000833570104139150181211222252282316351387422455488522558590620653688721755790802
doi:34601600083387793106
10.1177/­35871600083346780111139169205225241
17588359251326705.21401700083346496130166200233265298333364394427460493526560572
10.21401800085367085
Chansky223818000834078110148174204238
K,248918000833549
Detterbeck255118000834681103127161182222257290320
FC,28841800083327386
Nicholson29831800083445991129167183209247286
AG,32821800083418497
et339218000833456
al.34611800083324760
The353418000833372107
IASLC36541800083155690121159
Lung214019000833168106145
Cancer230319000834073111143177198
Staging25181900083335487126141179218
Project:27531900083365694109144176201214
External29851900083326589123144183215230
Validation3233190008336678297136168190205243282
of353219000833857
the36061900083226095
Revision3719190008335702140200008332497691130170
of233120000833858
the24102000083226298
TNM252920000833381137
Stage26872000083335589129165
Groupings287320000834567106145185201240280307
in320220000831553
the32772000083226197
Eighth33952000083344989128150190
Edition36062000083337388112127167206
of214021000833857
the22182100083226096
TNM233521000833279135
Classification24912100083405588115142157175192224258280295334373
of288421000833858
Lung296221000833269108147
Cancer.313021000834074112145179200211
J3362210008324
Thorac340721000833372111133166199
Oncol.362721000834786119156172186
2017;12(7):1109-1121.21402200083346799127137166196213247266277307334365399422453480509540549
doi:27022200083377590102
10.1016/j.jtho.2017.04.011.28162200083346577107138169200225240253269291328366378414447478507513548583596630661688698
Epub352622000833270108147
201736852200083346799127
Apr214023000834180102
28.22572300083346881
PMID:235423000833589104150163
28461257.253223000833568105141171201236269275
11.21402400085366576
Lad222824000833164102
T,234124000833341
Piantadosi23932400083354980117137169207244270284
S,268924000833244
Thomas274424000833271108165197222
P,297824000833538
et302824000833355
al.30942400083324658
A3164240008340
prospective32162400083385995121159194225249263295328
randomized3555240008321539012816522223721402500083286097
trial224825000832141558599
to235825000832156
determine24242500083377091123143199213249282
the27162500083215891
benefit281725000833872108141157174194
of302225000833654
surgical30862500083266181117131161192206
resection33022500083215378111142164178214251
of356325000833754
residual3628250008320527791128163214026000833246
disease21972600083385277111142168201
following2410260008318546983120170185222260
response26812600083205379117155192217251
of294326000833756
small301026000832682114128142
cell3163260008331647993
lung32672600083155188126
cancer340426000833163100131164184
to359926000832257
combination36682600083316612321402700083395491122143158195233
chemotherapy.239027000833169103160198219256291311344382413422
Chest.282927000834077111138160173
1994;106(630192700083346398133144174204239258290
Suppl):320S-323S.332627000833370108147162181192227258292324345377409443474486
doi:21402800083387690102
10.1378/chest.106.6_supplement.320s.22562800083346576106136167200224252290324350373385415446481494528565592629667706721755813847884905918953984101810441057
PMID:332728000833588103148160
7988254.350128000833467101136169203238249
12.21402900085366782
Yang223629000833564101140
CJ,23892900083406677
Chan248029000834077109146
DY,26402900083457886
Shah273929000833370101139
SA,28912900083337386
et299129000833456
al.30602900083324759
Long-term313229000833268106144166188221241299
Survival34452900083326989123138170202217
After36762900083415983116137
Surgery21403000083326990127161182215
Compared236830000834076134172204225258297
With26783000083577395132
Concurrent282330000834076114145182203224257295315
Chemoradiation315130000834077112169207227260298312344365379417454
for36183000083195676
Node-negative37073000083458321403100083377092129162199230250264295327
Small247731000833287118132145
Cell2633310008339718599
Lung274231000833166102139
Cancer.289131000833970106137169188197
Ann309831000834177113
Surg.32213100083326787123135
2018;268(6):11051112.3366310008334669612513616920123425228330031033836439442621403200083346188117129
doi:22833200083387690102
10.1097/SLA.0000000000002287.23993200083346576107137172204223255286328342377412447483518554589625660695731766798832865898903
PMID:331632000833588103148161
28475559.349032000833568103135167198230262272
13.21403300085366985
Noronha224633000834584106144184222255
V,252233000833746
Sekhar25893300083336899139172194
A,280433000834256
Patil28813300083366890106122
VM,302433000833692106
et315133000833457
al.32293300083324861
Systemic33123300083326390114149208223256
therapy35893300083226196118152192224
for21403400083195880
limited22413400083153190106129164205
stage24673400083275185125161
small264934000832786119136151
cell2822340008332668398
lung29423400083155393133
carcinoma.30963400083326688120136175214274307321
J3439340008324
Thorac348534000833373113135169202
Dis.37093400083466289103
2020;12(10):6275-6290.214035000833468101135148178208225257289307319354388421453475513546580616628
doi:27843500083387691104
10.21037/jtd-2019-sclc-11.29033500083346678114146177210242262278301339361392426458488512539571586618637668695705
14.21403600085366984
Veslemes22403600083366895110145203238265
M,252136000835468
Polyzos26043600083357288120151188214
A,283436000834155
Latsi29053600083316586114129
P,304936000833640
et310536000833456
al.31773600083314760
Optimal325236000834787109124182214230
duration34973600083387697130152167205244
of375636000833857
chemotherapy214037000833169104162200222261296317350389420
in257837000831452
small264737000832784117132147
cell2811370008332658196
lung29243700083155391130
cancer:307137000833164102134168189203
a3291370008332
randomized33413700083205391130168227242271305345
study37033700083264987214038000833870
of222838000833757
42303380008334
versus23553800083316687114151178
62551380008334
cycles26033800083316496111146173
of279438000833756
cisplatin-etoposide.28683800083324773112128160182197235257294316353392431458473512547559
J3445380008324
Chemother348738000834078113171209231269304325
1998;10:136-140.214039000833464100135147177208221251281316339370401437449
doi:26053900083387691104
10.1179/joc.1998.10.2.136.27243900083346678109137166199223239277310323354384419454468498530542578591622652686699
15.21404000085366984
Pignon22454000083355090128167206
JP,24724000083246065
Arriagada25584000083416385101133173206245278
R,285740000833650
Ihde29284000083145392128
DC,307740000834587100
et319840000833557
al.32764000083324861
A3358400008341
meta-analysis342040000835893116149172205243276292324351366393
of214041000833757
thoracic22184100083216098120153186201233
radiotherapy24724100083215493108147169207242264297336368
for28614100083185678
small-cell295941000832785117133148170204238254269
lung32494100083155391130
cancer.340041000833164102135169190201
N3621410008345
Engl368741000833371110125
J2140420008324
Med.218542000835591131144
N2350420008345
Engl241642000833371111127
J2564420008324
Med.260942000835590130144
1992;327(23):1618-1624.277442000833465101134147182216249266300335353365395427458489512543575609641654
doi:34494200083387793105
10.1056/35754200083356779111143177212237
NEJM199212033272302.394013000834578105159191221256289321351385418451483516551585620653665
PMID:462113000833588104150163
1331787.47991300083346497128157191224230
16.39401400085356781
Warde403214000835686106142175
P,421814000833438
Payne42661400083356594131164
D.444114000834454
Does450614000834481115140
thoracic46571400083215894114145176190220
irradiation4888140008314345485122136166187201237273
improve517214000831470107127163193226
survival54081400083266181114128159191205
and394015000833269107
local40611500083155385117132
control420715000833167105126146183198
in441915000831552
limited-stage44851500083152986100122155194216242264296335369
small-cell486815000832683115129144165198231246260
carcinoma51421500083326484115129166204261293
of544915000833756
the55191500083225993
lung?39401600083155187125148
A4099160008340
meta-analysis.415016000835690111142163194231261276306331345370382
J4543160008324
Clin45781600083395367103
Oncol.469216000834683114149164176
J4878160008324
Clin49131600083395367103
Oncol.502716000834784114150164176
1992;10(6):890895.52141600083346296128139168198216248265275309341376394017000833468101112
doi:40661700083387691102
10.1200/JCO.1992.10.6.890.41821700083346577107136169205229249289334345375404439471483513544556590603638672707719
PMID:491517000833588102148160
1316951.50891700083346393124157191221230
17.39401800085366877
Takada40381800083336192126165198
M,425618000835569
Fukuoka434618000833269100138177208242
M,460818000835569
Kawahara469818000833569120153192224246279
M,499818000835568
et508718000833457
al.51651800083324760
Phase524618000833673106133168
III54351800083153046
study55021800083264988394019000833870
of402619000833756
concurrent409819000833168106139176197219253291313
versus44271900083316587114151177
sequential462019000832661101138173211233248280295
thoracic49311900083226098120153185200232
radiotherapy51791900083205392107145167205240262295334365
in556019000831452
combination394020000833168126166181219251273288326365
with43212000083506688127
cisplatin44642000083314672111127159181196234
and471420000833270109
etoposide48392000083345693132171198213252287
for51422000083185677
limited-stage52352000083153088103125159198221248271304343378
small-cell394021000832683115130145167201234249264
lung42172100083155290128
cancer:435821000833164101133167188201
results45722100083205481118133155182
of476721000833756
the48362100083215994
Japan49422100083245695128166
Clinical51202100083405570107122154186201
Oncology533421000834785117154169207246278
Group394022000834465103141180
Study41372200083335492131163
9104.43172200083346698134146
J4481220008324
Clin45222200083405570108
Oncol.464822000834785117154170183
2002;20(14):3054-3060.484922000833468104137149184218238269300318330365399434469492524559594630642
doi:55092200083387691104
10.1200/JCO.2002.12.071.39402300083346678109139173209234254295341352388422459491504535565577612645677687
PMID:464223000833589104150163
12118018.48212300083346495123154189221252265
18.39402400085366985
Wu403924000835794
Q,414724000834761
Xiong42212400083395492130169
Y,440424000833543
Zhang446124000833876108146185
S,466024000833245
et471924000833456
al.47892400083324760
A4863240008341
Meta-Analysis491724000835590112145167209247279295326353368394
of532524000833757
the53952400083226095
Efficacy550424000833350688639402500083316496130
and408825000833270109
Toxicity42152500083326697112144159182215
of444825000833857
Twice-Daily45232500083338095127161184231263278294325
vs.48662500083325973
Once-Daily495725000834785117151174221254269284316
Concurrent529125000834077115147185206228262300322
Chemoradiotherapy394026000834078113171209231264303318356378416451472505544576
for45302600083185678
Limited-Stage462226000833147104120142176215238269290323362397
Small503326000833390123138153
Cell52002600083407490105
Lung531926000833269107146
Cancer54792600083407311139402700083326789
Based40502700083367098134175
on424627000833878
Randomized434527000833670109149189249264294330370
Controlled473727000834179118141163201218234270310
Trials.50692700083335167100116143157
Front52482700083335392131154
Oncol.542327000834888121159176189
2020;9:1460.394028000833468101135148184197226257294329342
doi:43012800083387792104
10.3389/fonc.2019.01460.44252800083346578113146181215238258295334366379415449481511522557589620656692704
PMID:514928000833589104150163
31970086;53322800083346595128161197233268280
PMCID:394029000833589129144190203
PMC6960125.415929000833588129163197232268299329364376
19.39403000085377084
Spigel40453000083337389129164180
DR,42473000083468397
Cheng436630000834079115154194
Y,458130000833644
Cho464630000834180119
BC,47863000083367891
et489930000833457
al.49773000083334862
ADRIATIC:506030000834288126142184214231272286
durvalumab53673000083397799135169184223394031000835890130
as409131000833258
consolidation417031000833169107134173189204243276298313351390
teratment45813100083225677110132191226265287
fot48883100083195779
patients49873100083397395110145184205233
with52413100083516789128
limited-53893100083153189104127161201223
-stage39403200083214872105145180
small-cell414132000832685117133148171205239255270
lung44323200083155392131
cancer458432000833265104136170192
(LS-SCLC).47973200083185085108140181213252273284
ASCO510232000834176117163
2024,528532000833569103135147
31.5.–54533200083356676111124160
4.6.,3940330008334478295108
Chicago,40633300083407893125158197235247
USA.432633000834375116131
20.39403400085367287
Senan404334000833268106138176
S,423534000833245
et429634000833456
al.43683400083324760
(D)44443400083186482
as454234000833158
consolidation461634000833168106133171187202241273295310348386
therapy50183400083226095116149188220
in525434000831452
limited-stage53223400083153087103125159198221247271394035000833271106
SCLC406135000833273104143
(LS-SCLC):42193500083185084107138178210248269281
Outcomes451535000834785108138175234269295
by482535000833970
prior49103500083396076114136
concurrent506135000833168106138176197219253291313
chemoradiotherapy53893500083316910416220039403600083215493108146168206241262295334366
(cCRT)43263600083184889125159181
regimen45273600083205494109167202240
and478736000833270109
prophylactic49163600083386097137175206222254286310326358
cranial52943600083315285123138170185
irradiation549936000831536589139403700083385385107122160199
(PCI)41543700083195495110129
use42983700083376398
in441237000831452
the44793700083226095
ADRIATIC458937000834187123139180209226266
trial.4871370008321435890106119
ESMO500537000833367121169
Congress518937000834077115154176210236263
2024,546737000833569101133145
September394038000833268107129163220260295316
13–17,427238000833464100131160166
Barcelona,44533800083366990121155170208247279292
Spain,476038000833372105120158170
LBA81.494638000833167108143174184
21.39403900085367082
Senan,403739000833268106138176189
et424139000833456
al.43133900083314760
Patterns43883900083356789113147168207233
of463639000833857
disease47083900083385379114146173208
progression49313900083396098137158192219246261299337
with52833900083516789127
durvalumab54263900083387596131164394040000831552110143182
(D)41384000083186482
after42364000083325176109131
concurrent438340000833168106138176197219253291313
chemoradiotherapy471240000833169104162200222255294309347369407442463496535567
(cCRT)52954000083184889125159181
in549240000831452
limited-stage55604000083153039404100083577295129168191217241273312347
small-cell430841000832683116131146169202236252267
lung45954100083155290129
cancer474541000833164102134168189
(LS-SCLC):49544100083195185107139179211249270282
Results52564100083357097134150172200
from54764100083194178136
ADRIATIC.394042000834187123139180209225266279
ELCC423542000833264102140
2025,439142000833468101136147
March455342000835587108140178
26–29,474642000833468105137171181
Paris,49434200083356788104130143
France.51014200083325285123155189201
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