Onkologie. 2025:19(4):230-236 | DOI: 10.36290/xon.2025.043

Biliary tract cancer

Marián Liberko^{1, 2}, Renata Soumarová^{1, 2}

¹ Onkologická klinika 3. LF UK a FNKV, Praha

² 3. lékařská fakulta Univerzity Karlovy, Praha

Biliary tract tumors represent a serious medical problem due to the high mortality rate. In the case of early stages, after potentially curative surgery, patients are indicated for postoperative therapy to reduce the risk of recurrence and prolong survival. Most patients with biliary tract cancer are diagnosed at locoregionally advanced and/or metastatic stages. The standard of care for these patients is systemic therapy, now combined with immunotherapy. Increasing knowledge of the molecular biology of this disease allows tailored treatment to be selected in a proportion of patients according to the presence of a specific targetable alteration. This article provides an overview of current therapeutic options for this disease across stages.

Keywords: biliary tract tumors, NGS testing, systemic therapy, immunotherapy, targeted therapy.

Accepted: September 30, 2025; Published: October 8, 2025  Show citation