Onkologie. 2009:3(3):170-175

Nutrition support in patients after stem cell transplantation

Miroslav Tomíška
Interní hematoonkologická klinika LF MU a FN Brno

Stem cell transplantation frequently bears a high risk of nutritional disturbances. The presence of undernutrition before conditioning

almost doubles the risk of transplant related mortality. Myeloablative preparation above all leads to severe catabolism and profound

depression of immunity. Prefered form of nutrition support during aplasia has been parenteral nutrition containing high amount of amino

acids. In myeloablative conditioning this is usually started early after graft infusion. In complications, especially in serious infections

or after occurence of graft versus host disease, it is necessary to provide systematic nutrition support with the use of various forms of

artificial nutrition.

Keywords: stem cell transplantation, nutrition support, parenteral nutrition, glutamine.

Published: June 15, 2009  Show citation

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Tomíška M. Nutrition support in patients after stem cell transplantation. Onkologie. 2009;3(3):170-175.
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    References

    1. Lenssen P, Bruemmer B, Saundra NA and McDonald GB. Nutrient support in hematopoietic cell transplantation. J Parenteral Enteral Nutr 2001; 25: 219-228. Go to original source... Go to PubMed...
    2. Masszi T. Nutritional and metabolic support. In: Apperley J, Carreras E, Gluckman E, Gratwohl A, Masszi T. Haematopoietic stem cell transplantation. The EBMT handbook. Paříž 2004; 119-125.
    3. Weisdorf SA, Lysne J, Wind D, et al. Positive effect of prophylactic total parenteral nutrition on long-term outcome of bone marrow transplantation. Transplantation 1987; 43: 833-838. Go to original source...
    4. Raynard B, Nitenberg G, Gory-Delabaere G, et al. Summary of the standards, options and recommendations for nutritional support in patients undergoing bone marrow transplantation (2002). Brit J Cancer 2003; 89(Suppl 1): S101-S106. Go to original source... Go to PubMed...
    5. Deeg HJ, Seidel K, Bruemmer B, Pepe MS and Appelbaum FR. Impact of patient weight on non-relapse mortality after marrow transplantation. Bone Marrow Transplant 1995; 15: 461-468. Go to PubMed...
    6. Hadjibabaie M, Iravani M, Takhizadeh M, et al. Evaluation of nutritional status in patients undergoing hematopoietic SCT. Bone Marrow Transplant 2008; 42: 469-473. Go to original source... Go to PubMed...
    7. Taskinen and Saarinen UM. Skeletal muscle protein reserve after bone marrow transplantation in children. Bone Marrow Transplant 1996; 18: 937-941. Go to PubMed...
    8. Horsley P, Bauer J, Gallagher B. Poor nutritional status prior to peripheral blood stem cell transplantation is associated with increased length of hospital stay. Bone Marrow Transplant 2005; 35: 1113-1116. Go to original source... Go to PubMed...
    9. Mattsson J, Westin S, Edlund S, Remberger M. Poor oral nutrition after allogeneic stem cell transplantation correlates significantly with severe graft-versus-host-disease. Bone Marrow Transplant 2006; 38: 629-633. Go to original source... Go to PubMed...
    10. Browning B, Thormann K, Seshadri R, et al. Weight loss and reduced body mass index: a critical issue in children with multiorgan chronic graft-versus-host disease. Bone Marrow Transplant 2006; 35: 527-533. Go to original source... Go to PubMed...
    11. Arfons LM and Lazarus HM. Total parenteral nutrition and hematopoietic stem cell transplantation: an expensive placebo? Bone Marrow Transplant 2005; 36:281-288. Go to original source... Go to PubMed...
    12. Roberts S, Miller J, Pineiro L and Jennings L. Total parenteral nutrition vs oral diet in autologous hematopoietic cell transplant recipients. Bone Marrow Transplant 2003; 32: 715-721. Go to original source... Go to PubMed...
    13. Ziegler TR, Young LS, Benfell K, et al. Clinical and metabolic efficacy of glutamine supplemented parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study. Ann Internal Med 1992; 116: 821-828. Go to original source... Go to PubMed...
    14. Muscaritoli M, Grieco G, Capria S, Iori AP, and Fanelli FR. Nutritional and metabolic support in patients undergoing bone marrow transplantation. Am J Clin Nutr 2002; 75: 183-190. Go to original source... Go to PubMed...
    15. Ziegler TR, Bye RL, Persinger RL, et al. Effects of glutamine supplementation on circulating lymhocytes after bone marrow transplantation: a pilot study. Am J Med Sci 1998; 315: 4-10. Go to original source...
    16. Schloerb PR, and Skikne BS. Oral and parenteral glutamine in bone marrow transplantation: a randomized, double-blind study. J Parenteral Enteral Nutr 1999; 23: 117-122. Go to original source... Go to PubMed...
    17. Bongers T, Griffiths RD, McArdle A. Exogenous glutamine: The clinical evidence. Crit Care Med 2007; 35: S545-S552. Go to original source... Go to PubMed...
    18. Pytlík R, Beneš P, Patorková M, et al. Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study. Bone Marrow Transplant 2002; 30: 953-961. Go to original source... Go to PubMed...
    19. Chamouard Cogoluenhes V, Chambrier C, Michallet M, et al. Energy expenditure during allogeneic and autologous bone marrow transplantation. Clin Nutrition 1998; 17: 253-257. Go to original source... Go to PubMed...
    20. Arends J, Bodoky G, Bozzetti F, et al. ESPEN guidelines on enteral nutrition: non-surgical oncology. Clin Nutr 2006; 25: 245-259. Go to original source... Go to PubMed...

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