Onkologie. 2015:9(3):125-127

Adult acute lymphoblastic leukemia

František Folber, Štěpán Hrabovský, Michael Doubek
Interní hematologická a onkologická klinika, Lékařská fakulta Masarykovy univerzity a Fakultní nemocnice Brno

Initial symptoms at diagnosis, essential diagnostic work-up procedures, current treatment guidelines and prognosis of adult acute lymphoblastic

leukemia are discussed in this review article. A separate section deals with several special subtypes of this disease and new

drugs or treatment approaches available recently or tested within ongoing clinical trials.

Keywords: acute lymphoblastic leukemia, adults, guidelines, treatment, haematopoietic stem cell transplantation

Published: June 1, 2015  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Folber F, Hrabovský Š, Doubek M. Adult acute lymphoblastic leukemia. Onkologie. 2015;9(3):125-127.
Download citation

References

  1. Bassan R, Hoelzer D. Modern therapy of acute lymphoblastic leukemia. J Clin Oncol 2011; 29: 532-543. Go to original source... Go to PubMed...
  2. Bassan R, Spinelli O, Oldani E, et al. Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL). Blood 2009; 113: 4153-4162. Go to original source... Go to PubMed...
  3. Raff T, Gökbuget N, Lüschen S, et al. Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials. Blood 2007; 109: 910-915. Go to original source... Go to PubMed...
  4. Doubek M, Folber F, Koristek Z, et al. Autologous hematopoietic stem cell transplantation in adult acute lymphoblastic leukemia: still not out of fashion. Ann Hematol 2009; 88: 881-887. Go to original source... Go to PubMed...
  5. Bassan R, Rossi G, Pogliani EM, Di Bona E, Angelucci E, Cavattoni I, et al. Chemotherapy-phased imatinib pulses improve long-term outcome of adult patients with philadelphia chromosome-positive acute lymphoblastic leukemia: Northern italy leukemia group protocol 09/00. J Clin Oncol 2010; 28(22): 3644-3652. Go to original source... Go to PubMed...
  6. Izraeli S. Beyond Philadelphia:, Ph-like' B cell precursor acute lymphoblastic leukemias - diagnostic challenges and therapeutic promises. Curr Opin Hematol 2014; 21(4): 289-296. Go to original source... Go to PubMed...
  7. Haydu JE, Ferrando AA. Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP T-ALL). Curr Opin Hematol. 2013; 20(4): 10.1097. Go to original source... Go to PubMed...
  8. Vignetti M, Fazi P, Cimino G, et al. Imatinib plus steroids induces complete remissions and prolonged survival in elderly Philadelphia chromosome-positive patients with acute lymphoblastic leukemia without additional chemotherapy: results of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) LAL0201-B protocol. Blood 2007; 109: 3676-3678. Go to original source... Go to PubMed...
  9. Brüggemann M, Schrauder A, Raff T, et al. Standardized MRD quantification in European ALL trials: proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008. Leukemia 2010; 24: 521-535. Go to original source... Go to PubMed...
  10. Fielding AK, Richards SM, Chopra R, et al. Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study. Blood 2007; 109: 944-950. Go to original source... Go to PubMed...
  11. Wetzler M, Sanford BL, Kurtzberg J, et al. Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511. Blood 2007; 109: 4164-4167. Go to original source... Go to PubMed...
  12. Topp MS, Kufer P, Gokbuget N, Goebeler M, Klinger M, Neumann S, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol 2011; 29(18): 2493-2498. Go to original source... Go to PubMed...
  13. Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 2013; 368(16): 1509-1518. Go to original source... Go to PubMed...
  14. Gökbuget N, Hartog C-M, Bassan R, et al. Liposomal cytarabine is effective and tolerable in the treatment of central nervous system relapse of acute lymphoblastic leukemia and very aggressive lymphoma. Haematologica 2011; 96(2): 238-244. Go to original source... Go to PubMed...
  15. Ottmann O, Dombret H, Martinelli G, et al. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 2007; 110: 2309-2315. Go to original source... Go to PubMed...
  16. Kantarjian H, Thomas D, Jorgensen J, et al. Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study. The Lancet Oncology 2012; 13(4): 403-411. Go to original source... Go to PubMed...
  17. Gökbuget N, Basara N, Baurmann H, Beck J, Brüggemann M, Diedrich H, et al. High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation. Blood 2011; 118(13): 3504-3511. Go to original source... Go to PubMed...
  18. Ottmann OG, Larson RA, Kantarjian HM, et al. Phase II study of nilotinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia. Leukemia 2013; 27: 1411-1413. Go to original source... Go to PubMed...
  19. Jabbour E, Kantarjian HM, Thomas DA, et al. Phase II study of combination of hyperCVAD with ponatinib in frontline therapy of patients with Philadelphia chromosome positive acute lymphoblastic leukemia. J Clin Oncol 2013; 31: abstr. 7024. Go to original source...
  20. Hoelzer D, Gökbuget N. Chemoimmunotherapy in acute lymphoblastic leukemia. Blood Reviews 2012; 26(1): 25-32. Go to original source... Go to PubMed...
  21. O'Brien S, Schiller G, Lister J, et al. High-Dose Vincristine Sulfate Liposome Injection for Advanced, Relapsed, and Refractory Adult Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia. JCO 2013; 31(6): 676-683. Go to original source... Go to PubMed...
  22. Dores GM, Devesa SS, Curtis RE, Linet MS, Morton LM. Acute leukemia incidence and patient survival among children and adults in the united states, 2001-2007. Blood 2012; 119(1): 34-43. Go to original source... Go to PubMed...




Oncology

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.