Onkologie. 2025:19(5):312-315 | DOI: 10.36290/xon.2025.056
Hidden threat: sarcomatoid transformation of germ cell tumor
- Klinika hemato-onkologie a buněčné terapie, Univerzitní nemocnice Magdeburg, Německo
Germline tumours are generally popular with oncologists as tumours with a very good prognosis, especially in the case of seminomas, even at advanced stages. Nevertheless, there are also high-risk groups where treatment can be difficult, and despite the use of toxic chemotherapy, we may not be able to save the patient. A separate issue is the so-called sarcomatoid transformation, which can develop in patients after previous cisplatin therapy. In my case report, I would like to present a patient who combined a number of these risk factors, which unfortunately led to the failure of our treatment.
Keywords: germ cell tumours, non-seminomas, yolk sac tumour sarcoma, transformation, chemotherapy.
Accepted: November 25, 2025; Published: December 15, 2025 Show citation
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