Onkologie. 2025:19(5):320-322 | DOI: 10.36290/xon.2025.058

Early diagnosis of immune-related myositis in a patient treated with pembrolizumab

Martina Spisarová, Martin Marhefka, Aviv Philip Goncharov
Onkologická klinika, Fakultní nemocnice Olomouc

In recent years, immunotherapy has played a key role in the treatment of numerous diseases. Renal carcinoma is one of the conditions in which the introduction of checkpoint inhibitors represented a real breakthrough in the entire management of the disease. Toxicity remains one of the major challenges associated with immunotherapy. The management of immune-related adverse events requires their early detection, which appears to be as important as their proper treatment.

Keywords: renal carcinoma, immunotherapy, checkpoint inhibitors, immune-related adverse events, myositis.

Accepted: November 25, 2025; Published: December 15, 2025  Show citation

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Spisarová M, Marhefka M, Goncharov AP. Early diagnosis of immune-related myositis in a patient treated with pembrolizumab. Onkologie. 2025;19(5):320-322. doi: 10.36290/xon.2025.058.
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    References

    1. Sundarrajan C, Bhai S, Dimachkie MM. Immune check­point inhibitor-related myositis: from pathophysiology to treat­ment. Clin Exp Rheumatol. 2023;41(2):379-385. Go to original source... Go to PubMed...
    2. Pathak R, Katel A, Massarelli E, et al. Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases. Oncologist. 2021;26(12):1052-1061. Go to original source... Go to PubMed...
    3. Vicino A, Hottinger AF, Latifyan S, et al. Immune check­point inhibitor-related myositis and myocarditis: diagnostic pitfalls and imaging contribution in a real-world, institutional case series. J Neurol. 2024;271(4): 1947-1958. Go to original source... Go to PubMed...

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