Onkologie. 2008:2(2):107-109

Haematopoietic stem cell transplantation - its effect on female sexual functioning

Ladislav, Slováček1, Birgita, Slováčková2, Ladislav, Jebavý1, Vladimír, Pavlík3, Zdeněk, Hrstka4
1 Katedra válečného vnitřního lékařství, Fakulta vojenského zdravotnictví Univerzity obrany, Hradec Králové
2 Psychiatrická klinika LF UK a FN Hradec Králové
3 Katedra vojenské hygieny, Fakulta vojenského zdravotnictví Univerzity obrany, Hradec Králové
4 Katedra veřejného zdravotnictví, Fakulta vojenského zdravotnictví Univerzity obrany, Hradec Králové

The haematopoietic stem cell transplantation (HSCT) is a therapeutic method especially used in the therapy of hematological malignancies. It known that HSCT has an influence on the course of the disease and the patient´s quality of life. The patient´s sexuality after HSCT is very observed aspect of their quality of life. The sexuality is impressed with physic, psychological and social factors. Main physic factors are breakdown of gonads, secondary vaginal changes related with total body irradiation and chemotherapy and chronic Graft Versus Host Disease. Main psychological factors influencing the sexuality are problems of somatic identification, breakdown of mood (depression, anxiety), lowered self-confidence, somatization, stigma, fears of return of disease. Main social factors influencing the sexuality are especially partner´s uncertainty and difficult cummunications between patient and partner or family member.

Keywords: hematopoietic stem cell transplantation, sexuality, quality of life

Published: August 1, 2008  Show citation

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Slováček L, Slováčková B, Jebavý L, Pavlík V, Hrstka Z. Haematopoietic stem cell transplantation - its effect on female sexual functioning. Onkologie. 2008;2(2):107-109.
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    References

    1. Albertazzi P, Natale V, Barbolini C, Teglio L, Di Micco R. The effect of tibolone versus cintinuous combined norethisterone acetate and oestradiol on memory, libido and mood of postmenopausal women: a pilot study. Maturitas 2000, 36: 223-229. Go to original source... Go to PubMed...
    2. Atkinson K. Chronic graft versus host disease folloving marrow transplantation. Marrow Transplant Rev 1992, 2: 1-7.
    3. Baker F et al. Quality of life of bone marrow transplant long-term survivors. Bone Marrow Transplant 1994, 13: 589-596. Go to PubMed...
    4. Brook CGD, Marshall NJ (eds). Essential Endocrinology, 4th edn. London: Blackwell Science, 2001.
    5. Bush NE et al. Quality of life of 125 adults surviving 6-18 years after bone marrow transplantation. Soc Sci Med 1995, 40: 479-490. Go to original source... Go to PubMed...
    6. Dennerstein L, Dudley EC, Hopper JL, Guthrie JR, Burger HG. A prospective population-based study of menopausal symptoms. Obstetrics Gynecol 2000, 96: 351-358. Go to original source... Go to PubMed...
    7. Dobkin PL et al. Assessement of sexual dysfunction in oncology patients: review, critique and suggestions. J Psychosocial Oncol 1991, 9: 43-74. Go to original source...
    8. Gradishar WJ, Schilsky RL. Ovarian function folloving radiation and chemotherapy for cancer. Semin Oncol 1989, 16: 425-436.
    9. Chatterjee R, Goldstone AH. Gonadal damage and effects on fertility in adult patients with haematological malignancy undergoing stem cell transplantation. Bone Marrow Transplant 1996, 17: 5-11. Go to PubMed...
    10. Chiodi S et al. Cyclic sex hormone replacement therapy in women undergoing allogeneic bone marrow transplantation: aims and results. Bone Marrow Transplant 1991, 8: 47-49.
    11. Klein CE et al. Gonadal complications. In: Armitage JO, Antman KH, eds. High-Dose Cancer Therapy. Pharmacology, Hematopoientins, Stem Cells: Williams and Wilkins, 1992: 555-566.
    12. Lichtman R. Perimenopausal and postmenopausal hormone replacement therapy. Part I. An update the literature on benefits and risks. J Nurse Midwifery 1996, 41: 3-28. Go to original source... Go to PubMed...
    13. Littley MD, Shalet SM, Morgestern GR, Deakin DP. Endocrine and reproductive dysfunction folloving fractionated total body irradiation in adults. Q J Med 1991, 78: 265-274.
    14. Mumma GH et al. Long-term psychosexual adjustment of acute leukemia survivors: impact of marrow transplantation versus conventional chemotherapy. General Hosp Psychiatry 1992, 14: 43-55. Go to original source... Go to PubMed...
    15. Sherins RJ. Gonadal dysfunction. In: Devita VT, Hellman S, Rosenberg SA eds. Cancer, Principles and Practice of Oncology, 4th edn. Philadelphia: Lippincott, 1993: 2395-2406.
    16. Schubert MA et al. Gynecological abnormalities following allogeneic bone marrow transplantation. Bone Marrow Transplant 1990, 5: 425-430. Go to PubMed...
    17. Slováček L, Slováčkova B, Jebavý L. Global Quality of Life in Patients Who Have Undergone the Haematopoietic Stem Cell Transplantation: A Finding from Transversal and Retrospective Study. Exp Oncol 2005, 27: 238-242.
    18. Soltes BA. Therapeutic options for menopause in cancer survivors. Oncol Nursing Updates 1997, 4: 1-12.
    19. Spinelli S, Chiodi S, Bacigalupo A et al. Ovarian recovery after total body irradiation and allogeneic bone marrow transplantation: long-term follow up of 79 females. Bone Marrow Transplant 1994, 14: 373-380. Go to PubMed...
    20. Thaler-De Mers D. Intimacy issues: sexuality, fertility and relationships. Seminars Oncol Nursing 2001, 17: 255-262. Go to original source... Go to PubMed...
    21. Watson M et al. Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation cheotherapy alone: analysis of the MRC AML 10 trial. Cancer 1999, 86: 1231-1236. Go to original source...
    22. World Health Organization. Education and Treatment in Human Sexuality. Technical Report. Geneva: World Health Organization, 1975.
    23. Zbytovský J, Balon R, Praško J, Seifertová D. Sexuální dysfunkce. In: Seifertová D, Praško J, Hoschl C. Postupy v léčbě psychických poruch, 1. vyd. Praha: Academia Medica Pragensis: 2004: 320-333.
    24. Zichella L. Clinical management of the menopausal woman. Int J Fertil Menopausal Stud 1993, 38: 15-22. Go to PubMed...
    25. Zvěřina J. Lékařská sexuologie, 1. vyd. Praha: HaH: 1991: 43-62.

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