Onkologie. 2008:2(3):163-166

HAIRY CELL LEUKEMIA

Luděk Raida1, Karel Indrák1, Pavel Žák2
1 Hemato-onkologická klinika FN a LF UP v Olomouci
2 II. interní klinika - Oddělení klinické hematologie, LF UK a FN Hradec Králové

Fifty years ago, hairy cell leukemia, relatively rare disease, was identified as an independent unit among the hematological malignancies. Over this period its treatment developed and the lymphoproliferative disease with fatal prognosis has become relatively benign one with longer survival of patients and normalized quality of their life. Hematological stabilization in splenectomised patients and the high therapeutic efficacy of lymphocytotoxic purine analogues, particularly cladribine, make the hairy cell leukemia to be a specific malignancy. It seems to be a feasible model for the investigation of the role of immunocompetent cells in the pathogenesis of indolent malignant lymphoproliferative diseases.

Keywords: Key words: hairy cell leukemia, splenectomy, α-interferon, 2´-deoxycoformycin, 2-chlorodeoxyadenosine, monoclonal antibodies.

Published: November 1, 2008  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Raida L, Indrák K, Žák P. HAIRY CELL LEUKEMIA. Onkologie. 2008;2(3):163-166.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Borouncle BA, Wiseman BK, Doan CA. Leukemic reticuloendotheliosis. Blood 1958; 13: 609-630. Go to original source...
    2. Schrek R, Donelly WJ. "Hairy" cell in blood in lymphoreticular neoplastic disease and "flagellated" cell of normal lymph nodes. Blood 1966; 27: 199-211. Go to original source... Go to PubMed...
    3. Jansen J, Schuit HRE, van Zwet TL et al. Hairy cell leukemia. A B lymphocytic disorder. Br J Haematol 1979; 42: 321-330. Go to original source... Go to PubMed...
    4. Duchayne E, Delsol G, Kuhlein E et al. Hairy cell transformation of a B-cell chronic lymphocytic leukemia: a morphological, cytochemical, phenotypic and molecular study. Leukemia 1991; 5: 150-155. Go to PubMed...
    5. Žák P, Chrobák L, Podzimek K et al. Neobvyklý průběh leukemie s vlasatými buňkami s výraznou abdominální lymfadenopatií, leukemickými infiltráty oční rohovky a kožními změnami. Vnitřní Lék 1998; 42: 463-466.
    6. Westbrook CA, Golde DW. Autoimmune disease in hairy cell leukemia: clinical syndromes and treatment. Br J Haematol 1985; 61: 349-356. Go to original source... Go to PubMed...
    7. Ambrosetti A, Semenzato G, Prior M et al. Serum level of soluble interleukin-2 receptor in hairy cell leukemia: a reliable marker of neoplastic bulk. Br J Haematol 1989; 73: 181-186. Go to original source... Go to PubMed...
    8. Catovsky D, Golde DW, Golomb HM. Meeting report. The third international workshop on hairy cell leukemia. Laguna Niguel, California 19-20 October 1989. Br J Haematol 1990; 74: 378-379. Go to original source...
    9. Chrobák L, Podzimek K, Kerekeš Z et al. Long-term results in hairy cell leukemia treated by splenectomy. Neoplasma 1993; 40: 133-136. Go to PubMed...
    10. Wiedermann D, Wiedermann B, Chrobák L et al. Immunoglobulin profiles and blood variables in 50 patients with hairy cell leukemia. Effect of splenectomy. Neoplasma 1984; 31: 191-196. Go to PubMed...
    11. Quesada JR, Manning JT, Hersh EM et al. Alfa interferon for induction of remission in hairy cell leukemia. N Engl J Med 1984; 310: 15-18. Go to original source... Go to PubMed...
    12. Catovsky D, Matutes E, Talavera JG et al. Long term results with 2´-deoxycoformycin in hairy cell leukemia. Leukemia Lymph 1994; 14: 109-113.
    13. Piro LD, Carrera CJ, Carson DA. Lasting remissions in hairy cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. N Engl J med 1990; 322: 1117-1121. Go to original source... Go to PubMed...
    14. Chacko J, Murphy C, Duggan C et al. Weekly intermittent 2-CdA is less toxic and equally efficacious when compared to continuous infusion in hairy cell leukemia. Br J Haematol 1999; 105: 1145-1150. Go to original source... Go to PubMed...
    15. Seymour JF, Kurzrock R, Freichreich EJ et al. 2-Chlorodeoxyadenosine induces durable remissions and prolonged suppression of CD4+ lymphocyte counts in patients with hairy cell leukemia. Blood 1994; 83: 2906-2911. Go to original source...
    16. Raida L, Papajík T, Faber E et al. Naše zkušenosti s terapií leukémií s vlasatými buňkami 2-chlorodeoxyadenosinem. Prakt Lék 1998; 78: 73-74.
    17. Saven A, Burian C, Koziol J et al. Long term follow-up of patients with hairy cell leukemia after cladribine treatment. Blood 1998; 92: 1918-1926. Go to original source...
    18. Nieva J, Bethel K, Saven A. Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia. Blood 2003; 102: 810-813. Go to original source... Go to PubMed...
    19. Hagberg H, Lundholm L. Rituximab, a chimeric anti-CD20 monoclonal antibody, in the treatment of hairy cell leukaemia. Br J Haematol 2001; 115: 609-611. Go to original source... Go to PubMed...
    20. Thomas DA, O'Brien S, Bueso-Ramos C et al. Rituximab in relapsed or refractory hairy cell leukaemia. Blood 2003; 102: 3906-3911. Go to original source... Go to PubMed...
    21. Kreitman RJ, Wilson WH, Robbins D et al. Responses in refractory hairy cell leukemia to a recombinant immunotoxin. Blood. 1999; 94: 3340-3348. Go to original source...
    22. Sugimori C, Kaito K, Nakao S. Persistent remission after immunosuppressive therapy of hairy cell leukemia mimicking aplastic anemia: two case reports. Int J Hematol 2003; 77: 391-394. Go to original source... Go to PubMed...
    23. Abramson N, Castro S. Remission of hairy cell leukemia without treatment. Haematologia 1997; 28: 259-264. Go to PubMed...
    24. Schmid M, Schrezenmeier H, Saib G et al. Evidence for a paracrine pathway of B-cell stimulation in hairy cell leukaemia. Br J Haematol 1995; 90: 156-162. Go to original source... Go to PubMed...

    Return to the content


    Oncology

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.