Onkologie. 2009:3(2):80-82

Renal cancer in adults

MUDr. Miroslav Podhola, Ph.D

Fingerlandův ústav patologie FN a LFUK Hradec Králové

Renal cell carcinomas account for 3 % of adult malignancies and 80 % malignant renal tumors. Men are more often affected than women

in a ratio of approximately 2 to 1. The carcinoma arises mainly in adults with a peak in 6th and 7th decade of life. In 5–10 % cases multicentric

tumor is observed and bilateral tumor in 1–6 % respectively. The prognosis is related to several parameters. There is a close correlation

between staging system and outcome. Size of the primary tumor relates to prognosis for the very small (less than 3 cm) and the very

large (over 12 cm) tumors. Nuclear grade of the tumor is an important predictor of survival especially in clear cell carcinoma and papillary

carcinoma. The WHO classification subdivides renal carcinomas into clear cell carcinoma, papillary carcinoma, chromophobe cell

carcinoma, collecting duct carcinoma, medullary carcinoma, renal carcinoma associated with Xp11.2 translocations / TFE3 gene fusions,

mucinous tubular and spindle cell carcinoma and unclassified carcinoma.

Keywords: kidney, renal cell carcinoma, classification.

Published: April 1, 2009  Show citation