Onkologie. 2010:4(3):162-163

The treatment of Hodgkin’s lymphoma in pregnancy

Lenka Šmardová¹, Martin Huser², Zdeněk Král¹, Igor Crha²

¹ Interní hematoonkologická klinika FN a LF MU, Brno

² Gynekologicko-porodnická klinika FN a LF MU, Brno

Lymphoma is the fourth most frequent malignancy diagnosed during pregnancy, occuring in approximately 1:6 000 of deliveries. Its

occurence may increase due to the current trend to postpone pregnancy until later in life. Chemotherapy and radiotherapy during the

first trimester are associated with increased risk of congenital malformations. In the vast majority of cases, when lymphoma is diagnosed

during the first trimester, treatment with a standard chemotherapy regimen, following pregnancy termination should be recommended.

In the rare patients at low risk, therapy can be delayed until the end of the first trimester and of embryogenesis while keeping the

patients under close observation. When lymphoma is diagnosed during the second and third trimesters, evidence exists suggesting that

full-dose chemotherapy can be administered safely without apparent increased risk of severe fetal outcome.

Keywords: lymphoma, pregnancy, chemotherapy, malformations

Published: July 1, 2010  Show citation