Onkologie. 2010:4(4):225-228
Malignant melanoma
- Dermatovenerologická klinika LF UK a FN Plzeň
Malignant melanoma is a malignant skin tumor with the tendency to metastasize. The incidence of melanoma increases. The genetic
predisposition and UV radiation are the most important factors in the etiopathogenesis of melanoma. We distinguish 4 clinical subtypes
of melanoma: lentigo maligna melanoma, superficial spreading melanoma, nodular melanoma and acrolentiginous melanoma. Malignant
melanoma can metastasize into the skin, subcutis, lymph nodes or other visceral organs. The prognosis of thin melanomas is good
in contrast to that of thick melanomas and melanomas with metastases. The preventive campaigns, screening of high-risk patients,
accurate diagnostics, surgical therapy and follow-up of patients with melanoma are of major importance.
Keywords: malignant melanoma, etiopathogenesis, clinical examination, therapy, prevention, follow-up
Published: October 1, 2010 Show citation
References
- Pizinger K. Kožní pigmentové projevy. 1. vyd. Praha: Grada, 2003: 124.
- Roesch A, Volkenandt M. Melanoma. In: Braun-Falco' Dermatology. 3rd Edition, Heidelberg: Springer, 2009: 1416-1432.
Go to original source... - Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patiens: Validation of the American Point Committee on Cancer staging system. J Clin Oncol. 2001; 19: 3622. Go to original source...
Go to PubMed... - Krajsová I. Melanom. 1. vyd. Praha: Jessenius Maxdorf, 2006: 332.
- Pizinger K, Fikrle T. Stanovení významu některých rizikových faktorů při vzniku maligního melanomu. Závěrečná zpráva grantového projektu IGA MZ ČR: NR8790-3, 2006-2008.
- Langley RGB, Sober AJ. A clinical review of the evidence for the role of ultraviolet radiation in the etiology of cutaneous melanoma. Cancer Incest. 1997; 15: 561. Go to original source... Go to PubMed...
- Nestle FO, Kerl H. Melanoma. In: Bologna JL, et al. Dermatology. Mosby, 2003: 1789-1815.
- Holly EA, Kelly JV, Shpall SN, Chiu SH. Number of melanocytic nevi as a major risk factor for malignant melanoma. J Am Acad Dermatol. 1987; 17: 459-468. Go to original source... Go to PubMed...
- Kreamer KH, Greene MH, Tarone R, et al. Dysplastic naevi and cutaneous melanoma risk. Lancet. 1983; 2: 1076-1077. Go to original source... Go to PubMed...
- Tucker MA, Halpern A, Holly EA, et al. Clinically recognized dysplastic nevi: A central risk factor for cutaneous melanoma. JAMA. 1997; 277: 1439-1444. Go to original source... Go to PubMed...
- Pock L, Fikrle T, Drlík L, Zloský P. Dermatoskopický atlas, 2. vyd. Praha: Phlebomedica, 2008: 149.
- Pehamberger H, Steiner A, Wolff K. In vivo epiluminiscence microscopy of pigmented skin lesions. I. Pattern analyses of pigmented skin lesions. J Am Acad Dermatol. 1987; 17: 571-583. Go to original source... Go to PubMed...
- Fikrle T, Pizinger K. Dermatoscopic differences between atypical melanocytic nevi and thin malignant melanomas. Melanoma Research. 2006; 16: 45-50. Go to original source... Go to PubMed...
- Kittler H, Pehamberger H, Wolff K, et al. Follow-up of melanocytic skin lesions with digital epiluminiscence microscopy: Patterns of modification observed in early melanoma, atypical nevi, and common nevi. J Am Acad Dermatol. 2000; 43: 467-476. Go to original source... Go to PubMed...
- Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg. 1970; 172: 902-908. Go to original source... Go to PubMed...
- Goldberg MS, Doucette JT, Lim HW, et al. Risk factors for presumptive melanoma in skin cancer screening: American Academy of Dermatology National Melanoma/Skin cancer screening program experience 2001-2005. J Am Acad Dermatol. 2007; 57: 60-66. Go to original source... Go to PubMed...
- Bradford PT, Freedman DM, Goldstein AM, Tucker MA. Increased risk of second primary cancers after a diagnosis of melanoma. Arch Dermatol. 2010; 146(3): 265-272. Go to original source... Go to PubMed...