Onkologie. 2010:4(5):308-310

Systemic therapy of adults soft-tissue sarcoma except GIST

Dagmar Adámková Krákorová
Klinika komplexní onkologické péče, Masarykův onkologický ústav, Brno

Multidisciplinary treatments planning is mandatory in all cases of soft-tissue sarcoma. Surgery is the standard treatment for all patients

with adult-type, localised tumor, complemented by radiation therapy in selected cased. The role of chemotherapy is not clearly defined.

Palliative chemotherapy may be added as an option in the treatment for unresectable locally advanced or metastatic disease.

Keywords: soft-tissue sarcoma, chemotherapy, target therapy

Published: December 31, 2010  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Adámková Krákorová D. Systemic therapy of adults soft-tissue sarcoma except GIST. Onkologie. 2010;4(5):308-310.
Download citation

References

  1. Brennan MF, Alektiar KM, Maki RG. Soft Tissue Sarcoma. In De Vita VT, Hellmann S, Rosenberg SA (eds.). Cancer Principles and Practise Of Oncology, (7th ed). Philadelphia: Lippincot Williams and Wilkins, 2005: 1581-1637.
  2. NCCN Clinical Practise Guidlines in Oncology, Soft Tissues Sarcoma, V. 2/2010.
  3. Cancer Management: A Multidisciplinary Approach, 12th edition, edited by Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ, 2009, chapter 22, 585-614.
  4. Kubáčková K. Chemoterapie sarkomů měkkých tkání. Referátový výběr z onkologie, speciál I/07, ročník 24: 14-21.
  5. Gortzak E, Azzarelli A, Bueas J, et al. A randomized phase II study on neo-adjuvant chemotherapy for, ,high risk" adult soft tissue sarcoma. Eur J Cancer 2001; 37: 1096-1103. Go to original source... Go to PubMed...
  6. DeLaney TF, Spiro IJ, Suit HD, et al. Neoadjuvant chemotherapy and radiotherapy for large extremity soft-tissue sarcomas. Int J Radiat Oncol Biol Phys 2003; 56: 1117-1127. Go to original source... Go to PubMed...
  7. Pisters PW, Patel SR, Prieto VG, et al. Phase I trial of preoperative doxorubicin-based concurrent chemoradiation and surgical resection for localized extremity and body wall soft tissue sarcoma. J Clin Oncol 2004; 2: 3375-3380. Go to original source... Go to PubMed...
  8. Sarcoma Meta-analysis Collaboration. Adjuvant chemotherapy for localized resectable soft tissue sarcoma of adults: metaanalysis of individual data. Lancet 1997; 350: 1647-1654.
  9. Cormier JN, Huang X, Xing Y, et al. Cohort Analysis of Patients With Localized, High-Risk, Extremity Soft Tissue Sarcoma Treated at Two Cancer Centres: Chemotherapy-Associated Outcomes. J Clin Oncol. 2004; 22: 4567-4574. Go to original source... Go to PubMed...
  10. Frustaci S, Gherlinzoni F, de Paoli A, et al. Adjuvant chemotherapy for adult soft tissue sarcoma of the extremity and girdles.: results of the Italian randomized cooperative trial. J Clin Oncol 2001; 19: 1238-1247. Go to original source... Go to PubMed...
  11. Woll PJ, van Glabbeke M, Hohenberger P, et al. Adjuvant chemotherapy (CT) with doxorubicin and ifosfamide in resected soft tissue sarcoma (STS): Interim analysis of a randomized phase III trial. J Clin Oncol. 2007; 25: 10008. Go to original source...
  12. Pervaiz N, Colterjohn N, Farrokhyar F, et al. A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer 2008; 113: 573-581. Go to original source... Go to PubMed...
  13. Bramwell VH, Anderson D, CHarette ML. Doxorubicinbased chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma. Chochrane Database Syst Rev 2003(3): CD003293. Go to original source...
  14. Nielsen OS, Judson I, vanHoesel Q, et al. Effect of high dose ifosfamide in advanced soft tissue sarcomas. A multicentre study of the EORTC soft tissue and bone sarcoma group. Eur J Cancer, 2000; 36: 61-67. Go to original source... Go to PubMed...
  15. Antman K, Crowley J, Balcerzak S, et al. An intergroup phase III randomized study of doxorubicin and dacarbazin with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas. J Clin Oncol. 1993; 11: 1276-1285. Go to original source... Go to PubMed...
  16. Verma S, Younus J, Stys-Norman D, Haynes AE, Blackstein M. Ifosfamide-based combination chemotherapy in advanced soft-tissue sarcoma: a practise guidline. Curr Oncol. 2007; 14(4): 144-148. Go to original source... Go to PubMed...
  17. Lorigan P, Verwij J, Papai Z, Rodenhuis S, Le Cesne A, Leahy MG, Radford JA, Van Glabbeke MM, Kirkpatrick A, Hogendoorn PC, Blay JY. Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: a European Organization of Research and Treatment of Cancer, Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol 2007; 20, 25(21): 3144-3150. Go to original source... Go to PubMed...
  18. Le Cesne A, Judson I, Crowther D, Rodenhuis S, Keizer HJ, Van Hoesel Q, Blay JY, Frisch J, Van Glabbeke M, Hermans C, Van Oosterom A, Tursz T, Verweij J. Randomized phase III study comparing conventional dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas. A trial of the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group. J Clin Oncol. 2000; 18(14): 2676-2684. Go to original source... Go to PubMed...
  19. Verma S, Younus J, Stys-Norman D, Haynes AE, Blackstein M. Meta-analysis of ifosfamide-based combination chemotherapy in advanced soft tissue sarcoma. Cancer Treat Rev. 2008; 34(4): 339-347. Go to original source... Go to PubMed...
  20. Le Cesne A, Blay JY, Judson I, et al. Phase II Study of ET-743 in Advanced Soft Tissue Sarcomas: A European Organisation for the Research and Treatment of Cancer, Soft Tissue and Bone Sarcoma Group Trial. J Clin Oncol. 2005; 23: 576-584. Go to original source... Go to PubMed...
  21. Hensley ML, Maki R, Venkatrman E, et al. Gemcitabin and Docetaxel in patients With Unresectable Leiomysarcoma. Results of phase II Trial. J Clin Oncol 2007; 8: 595-602.
  22. Bay JO, Ray-Coquaard I, Fayette J, et al. Docetaxel and gemcitabin combination in 133 advanced soft tissue sarcomas. A retrospective analysis. Internat. Journal of cancer. 2006; 119: 706-711. Go to original source... Go to PubMed...
  23. Penel N, Bui BN, Bay JO, et al. Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol 2008; 26: 5269-5274. Go to original source... Go to PubMed...
  24. Schlemmer M, Reichardt P, Verweij J, et al. Paclitaxel in patients with advanced angiosarcomas of the soft tissue. A retrospective study of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer. 2008; 44(16): 2433-2436. Go to original source... Go to PubMed...




Oncology

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.