Onkologie. 2010:4(6):344-348

Pancreatic neuroendocrine tumors therapy - surgeon’s perspective

Zdeněk Kala, Jan Hlavsa, Vladimír Procházka, Petr Kysela, Filip Marek, Roman Svatoň
Chirurgická klinika FN Brno

The authors put forward a review article summarizing current opinion in diagnostics and therapy of pancreatic neuroendocrine tumors.

They present actual TNM classification of these tumors highlighting CT, MRI, EUS and octreoscan as standard imaging methods. In the

field of therapy, radical, R0 resection, which brings the best overall survival, is accented. They also accept the possibility of debulking

resections and liver transplantation in the cases of local advanced and metastatic disease respectively. They point out the different

prognosis of pancreatic neuroendocrine tumors and pancreatic cancer. At the end the authors emphasize the importace of multimodal

aproach and cooperation, which is demonstrated in two case reports.

Keywords: pancreas, neuroendocrine tumor, surgery

Published: January 1, 2011  Show citation

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Kala Z, Hlavsa J, Procházka V, Kysela P, Marek F, Svatoň R. Pancreatic neuroendocrine tumors therapy - surgeon’s perspective. Onkologie. 2010;4(6):344-348.
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    References

    1. Neuroendocrine gastroenteropancreatic tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 21(Suppl 5): 223-227. Go to PubMed...
    2. Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, et al. One hundred years after, ,carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008; 26: 3063-3072. Go to original source... Go to PubMed...
    3. Ehehalt F, Saeger H, Schmidt C, Grützmann R. Neuroendocrine tumors of the pancreas. Oncologist 2009; 12: 456-467. Go to original source... Go to PubMed...
    4. Solcia E, Kloppel G, Sobin L. Histological typing of the endocrine tumours. Berlin Heidelberg: Springer-Verlag; 2000. Go to original source...
    5. Louthan O. Neuroendokrinní nádory, klinické pohledy, Praha: Grada Publishing 2006.
    6. Krenning EP, Bakker WH, Kooij PPM, Breeman WAP, et al. Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1] - octreotide in man: metabolism, dosimetry and comparison with [123I-Tyr3] octreotide, J Nucl Med 1992; 33: 652-658. Go to PubMed...
    7. Gines A, Vazquez-Sequeiros E, Soria MT, Clain JE, Wiersema MJ. Usefulness of EUS-guided fine needle aspiration (EUS-FNA) in the diagnosis of functioning neuroendocrine tumors. Gastrointest Endosc 2002; 56: 291-296. Go to original source... Go to PubMed...
    8. Limmer, et al. RFA of solitary pancreatic insulinoma in a patient eith episodes of severe hypoglycemia, Eur J GastroenteroHepatol 2009; 21(9): 1097-1101. Go to original source... Go to PubMed...
    9. Norton JA. Neuroendocrine tumors of the pancreas and duodenum. Curr Probl Surg 1994; 31: 77-156. Go to original source... Go to PubMed...
    10. Delcore R, Friesen SR. Gastrointestinal neuroendocrine tumors. J Am Coll Surg 1994; 178: 187-211. Go to PubMed...
    11. Bartsch DK, Schilling T, Ramaswamy A, Gerdes B, Celik I, Wagner HJ, et al. Management of nonfunctioning islet cell carcinomas. World J Surg 2000; 24: 1418-1424. Go to original source... Go to PubMed...
    12. Matthews BD, Heniford BT, Reardon PR, Brunicardi FC, Greene FL. Surgical experience with nonfunctioning neuroendocrine tumors of the pancreas. Am Surg 2000; 66: 1116-1122. Go to original source... Go to PubMed...
    13. Falconi M, Bettini R, Boninsegna L, Crippa S, Butturini G, Pederzoli P. Surgical Strategy in the Treatment of Pancreatic Neuroendocrine Tumors, JOP. J Pancreas (Online) 2006; 7(Suppl 1): 150-156.
    14. Del Chiaro M, et al. Surgical Approaches to the Treatment of Pancreatic Neuroendocrine Tumors with Synchronous Hepatic Metastases. JOP. J Pancreas (Online) 2004; 5(Suppl 5): 434-435.
    15. Chamberlain RS, Canes D, Brown KT, Saltz L, Jarnagin W, Fong Y, Blumgart LH. Hepatic neuroendocrine metastases: does intervention alter outcomes? J Am Coll Surg 2000; 190: 432-445. Go to original source... Go to PubMed...
    16. Chen H, Hardacre JM, Uzar A, Cameron JL, Choti MA. Isolated liver metastases from neuroendocrine tumors: does resection prolong survival? J Am Coll Surg 1998; 187: 88-92. Go to original source... Go to PubMed...
    17. Therasse E, Breittmayer F, Roche A, De Baere T, Indushekar S, Ducreux M, et al. Transcatheter chemoembolization of progressive carcinoid liver metastasis. Radiology 1993; 189: 541-547. Go to original source... Go to PubMed...
    18. Mavligit GM, Pollock RE, Evans HL, Wallace S. Durable hepatic tumor regression after arterial chemoembolization-infusion in patients with islet cell carcinoma of the pancreas metastatic to the liver. Cancer 1993; 72: 375-380. Go to original source...
    19. Clouse ME, Perry L, Stuart K, Stokes KR. Hepatic arterial chemoembolization for metastatic neuroendocrine tumors. Digestion 1994; 55(Suppl 3): 92-97. Go to original source... Go to PubMed...
    20. Diaco DS, Hajarizadeh H, Mueller CR, Fletcher WS, Pommier RF, Woltering EA. Treatment of metastatic carcinoid tumors using multimodality therapy of octreotide acetate, intra-arterial chemotherapy, and hepatic arterial chemoembolization. Am J Surg 1995; 169: 523-528. Go to original source... Go to PubMed...
    21. Falconi M, Bettini R, Boninsegna L, Crippa S, Butturini G, Pederzoli P. Surgical Strategy in the Treatment of Pancreatic Neuroendocrine Tumors, JOP. J Pancreas (Online) 2006; 7(Suppl. 1): 150-156.
    22. Lang H, Oldhafer KJ, Weimann A, Schlitt HJ, Scheumann GF, Flemming P, et al. Liver transplantation for metastatic neuroendocrine tumors. Ann Surg 1997; 225: 347-354. Go to original source... Go to PubMed...
    23. Frilling A, Rogiers X, Malago M, Liedke O, Kaun M, Broelsch CE. Liver transplantation in patients with liver metastases of neuroendocrine tumors. Transplant Proc 1998; 30: 3298-3300. Go to original source... Go to PubMed...
    24. Le Treut YP, Delpero JR, Dousset B, Cherqui D, Segol P, Mantion G, et al. Results of liver transplantation in the treatment of metastatic neuroendocrine tumors. A 31-case French multicentric report. Ann Surg 1997; 225: 355-364. Go to original source... Go to PubMed...

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