Onkologie. 2011:5(3):131-137

Recent possibilities of myeloma bone disease diagnostics

Vlastimil Ščudla¹, Miroslav Heřman², Miroslav Mysliveček³

¹ III. interní klinika FN a LF UP Olomouc

² Radiologická klinika FN a LF UP Olomouc

³ Klinika nukleární medicíny FN a LF UP Olomouc

The paper presents recent opinion on individual imaging methods in the diagnostics of multiple myeloma (MM), and its differentiation

from monoclonal gammopathy of undetermined significance (MGUS). We assess the possibilities and difficulties in the differentiation

of individual manifestations of myeloma bone disease using conventional radiography, computed tomography (CT), magnetic resonance

imaging (including whole body MR), 99mTc-MIBI scintigraphy, and FDG-PET/CT which combines positron emission tomography and

multidetector computed tomography. We describe the contribution of new imaging methods for MM stratification (Durie-Salmon Plus

staging system), monitoring of the course of MM including therapeutics response, recognition of relapse/progression, and extramedular

progression of the disease. We also evaluate interpretation difficulties of individual imaging methods, and the principles of their

individual choice in specific clinical situations.

Keywords: multiple myeloma, monoclonal gammopathy of undetermined significance, conventional radiography, computed tomography, whole-body magnetic resonance, 99mTc-MIBI scintigraphy, positron emission tomography/computed tomography (FDG-PET/CT)

Published: July 1, 2011  Show citation