Onkologie. 2011:5(3):175-180

Multiple cancers of nervous system and other primary neoplasms

Edvard Geryk¹, Jiří Kozel², Radim Štampach², Dalibor Pacík¹, Petr Dítě¹, Petr Kubíček², Milan Konečný²

¹ Fakultní nemocnice Brno

² Geografický ústav Přírodovědecké fakulty Masarykovy univerzity Brno

The number of malignant neoplasms of central nervous system (MN CNS), based in the Czech Cancer Registry, reached 26,548 diseases,

of which there were 14,263 (53.7 %) of males and 12,285 (46.3 %) of females in 1959–2008, presented 412 (8.1 per 100,000 males) and

418 (7.9 per 100,000 females) diseases in 2008. Their prevalence increased from 1,169 to 2,565 survived cases between 1989–2005, with

3,430 cases expected in 2015. A total of 962 registered multiple MN CNS there were 150 primary diseases in males and 162 in females,

327 subsequent MN CNS in males and 323 in females, i. e. 5.1 % in males and 6.2 % in females of all newly registered MN CNS in period

1976–2005. In this period the number of primary cases increased twice, of subsequent ones nearly 30 times during five periods. The

primary and subsequent MN CNS prevailed in the age group till 49 years in females over males, in the age group 50–69 years in males

over females. A total of 14 Czech regions there were distributed 47 % of all multiple MN CNS in the four regions (Northern and Southern

Moravia, Prague, Central Bohemia).

Only 6.2 % multiplicities were registered in early and 7.4 % in advanced clinical stages; 86.4 % stages were unregistered. The average

interval between 150 primary MN CNS and 170 other subsequent neoplasms was five years in males, between 162 primary and 170 subsequent

cases six years in females, of which the most frequent were following digestive and skin carcinomas in both sex. In 327 subsequent

MN CNS preceded 390 primary cancers in males, in 323 subsequent were 362 primary cases in females, of which the most frequent were

carcinomas of skin, female genital and breast, prostate and digestive tract. A total of 962 multiple MN CNS there were only 91 survived

and 871 death patients up to analysis in October 2007 with predominance of surviving females over males.

Keywords: cancers of nervous system, incidence, prevalence, multiple cancers, primary and subsequent neoplasms

Published: July 1, 2011  Show citation