Onkologie. 2011:5(5):278-283

Chemotherapy and biological therapy of colorectal cancer with the aim to achieve

Jana Halámková¹, Jiří Tomášek¹, Šárka Bohatá², Igor Kiss¹

¹ Klinika komplexní onkologické péče, Masarykův onkologický ústav a LF Masarykovy univerzity Brno

² Radiodiagnostická klinika FN Brno a LF Masarykovy univerzity Brno

resectability of primarily unresectable disease

Colorectal cancer is one of the most common malignant tumors in the Czech Republic, and up to 40 % of patients are diagnosed at an

advanced stage. Surgical treatment is the primary modality of therapy leading to cure colorectal cancer even in advanced disease. The

introduction of new chemotherapeutic agents in practice greatly increased treatment options in patients who are not surgically curable.

In combination with biological therapy, it can be achieved operability even in recently unresectable stage and thereby significantly prolonged

life of patients with metastatic colorectal carcinoma. In patients with metastatic liver disease, both resectable or unresectable,

is usually used neoadjuvant chemotherapy/chemobiotherapy. Although there is not defined the best treatment regimen yet, a basic

requirement is low toxicity and high efficiency.

Keywords: colorectal cancer, liver metastases, neoadjuvant therapy

Published: November 1, 2011  Show citation