Onkologie. 2011:5(6):333-335

Functional imaging and therapy of neuroendocrine tumors using metaiodobenzylguanidine

Kateřina Táborská

Klinika nukleární medicíny a endokrinologie UK 2. LF a FN Motol, Praha

Metaiodobenzylguanidine (MIBG) is a norepinephrine analog which concentrates in the adrenal medulla and MIBG scintigraphy is the

first choise of functional imaging of pheochromocytoma. Radioiodinated MIBG can be futher used both diagnostically and therapeutically

for patiens with paraganglioma, carcinoid and medullary thyroid carcinoma. An effectiveness of MIBG treatment involve achieving

symptom control and better quality of life. Biochemical response is observed in about half of the patiens, whereas radiographic can be

seen in around one third of the patiens in the literature. There has not been clear consensus about the optimal administered activity per

treatment cycle and the total numer of treatments with regards to hematological toxicity.

Keywords: neuroendocrine tumors, nuclear medicine, 131I-Iodine-metaiodobenzylguanidine

Published: December 1, 2011  Show citation