Onkologie. 2012:6(5):269-271

Neoadjuvant chemotherapy in livermetastatic colorectal carcinoma

Miroslav Ryska

Chirurgická klinika 2. LF UK a ÚVN, Praha

The occurrence of livermetastatic colorectal carcinoma is related to the incidence of colorectal cancer (CRC) which, in the Czech Republic,

is one of the highest worldwide with approximately 90 new cases per 100.000 inhabitants/year. Overall, 9.000 new cases of the disease

occur annually. Sixty percent of them develop generalized disease in the form of liver metastases. Radical treatment involves liver resection

and administration of adjuvant chemotherapy. The authors report the types of liver resections, the degree of radicality, the factors

resulting in contraindication of liver resection as well as the options of increasing the percentage of resectability. The best treatment

outcomes are achieved with a multimodal approach using a personalized approach to each patient.

Keywords: colorectal cancer, liver metastases, liver resection, chemotherapy, multimodal approach

Published: November 1, 2012  Show citation