Onkologie. 2012:6(5):272-277

Neoadjuvant therapy of breast cancer

Mária Wagnerová

Klinika rádioterapie a onkológie, VOÚ, a. s., Košice

Breast cancer is a model of quickly development scientific knowledges begining from molecular diagnostic and termination with targeted

therapies on the molecular level. Neoadjuvant chemotherapy is indicated for very heterogeneous group of tumours. Treatment

type is decided not only by biologic variability (receptor status, HER-2 status) but with individual variability (PS, comorbidity, extent of

illness). Primary systemic treatment (neoadjuvant, induction, inicials) is standard treatment for locally advanced tumor and for some

eligible type of surgery breast cancer, too. If treatment response is not satisfied it is necessary to look for new treatment regimens with

different concept of dose intensity, density and sequence of treatment. In the neoadjuvant setting it is possible to employ all targeted

and non-targeted therapies as was shown in a number of clinical trials.

Keywords: breast cancer, neoadjuvant therapy, complet pathologic remission, targeted therapy

Published: November 1, 2012  Show citation