Onkologie. 2013:7(1):24-28

Modern, individualized treatment of chronic lymphotic leukemia

Petra Obrtlíková

I. interní klinika &ndash, klinika hematoonkologie, Všeobecná fakultní nemocnice v Praze a 1. lékařská fakulta UK, Praha

The treatment of chronic lymphocytic leukemia (CLL) has achieved extraordinary progress over the last years. An important milestone

in the treatment of CLL was reached with the incorporation of monoclonal antibodies and combined chemoimmunotherapy which led to

significant improvements in treatment outcomes and survival advantage for the first time. Despite these therapeutic successes, CLL is still

considered to be an incurable disease. Only the allogenic transplantation is potentially curative but it is feasible only for selected group

of younger patients. There is an effort to individualize the treatment of patients with regard to the age of patients, biological factors,

comorbidities and our therapeutic goals. The development of new drugs and treatment combinations in CLL have evolved rapidly and

give us the hope for further improvement of the prognosis of our patients.

Keywords: chronic lymphocytic leukemia, monoclonal antibodies, chemoimmunotherapy, microenvironment

Published: February 1, 2013  Show citation