Onkologie. 2013:7(3):135-139

The incidence of other neoplasms in patients with leukemia

Edvard Geryk¹, Radim Štampach², Jiří Kozel², Petr Dítě¹, Milan Konečný²

¹ Fakultní nemocnice, Brno

² Geografický ústav Přírodovědecké fakulty, Masarykova univerzita Brno

A total of 30,166 cases of leukemia, based on the Czech Cancer Registry in 1976–2005, there were notificated 3,937 multiple cases associated

with the ocurrence of other neoplasms. Of them there were 2,450 (62.2 %) in males and 1,487 (37.8 %) in females, i.e. 14.7 % cases in males and

11 % in females of total registered leukemia. There were diagnosed 2,064 other neoplasms after 1,715 primary leukemias and 2,642 other

primary neoplasms before 2,222 subsequent leukemias. A total of 14 Czech regions were distributed 35.5 % multiple leukemias in the three

regions (Southern and Northern Moravia, Prague). In the average interval 4.9 years in males and 5.5 years in females followed 35.1 % cancer of

skin and melanoma, 16.9 % digestive, 13 % respiratory and 8.4 % urinary system. The expected low representation of advanced clinical stages

in subsequent cancers was not confirmed: in males 43.8 % cancer of oral cavity, 41.5 % respiratory, 34.2 % digestive, 10.6 % urinary and 15.7 %

genital organs; in females 39.4 % respiratory, 30.6 % urinary, 30 % digestive and 28.2 % genital organs, 25 % breast, 25 % oral cavity. Unfortunatelly

a lot of clinical stages were not registered. Before the subsequent leukemias the most frequent were 43.6 % primary cancers of skin

and melanoma as a sign of malignant status. Up to October 2007 in males survived only 12.4 % of primary and 10.3 % subsequent leukemias,

respective 19.7 % and 14 % in females. How many other neoplasms will be diagnosed among 8,000 surviving with leukemia, estimated in the

Czech Republic in 2015? The analyses of multiple neoplasms should be possible to illuminate the mechanisms of susceptibility to multiple cancers

and provide insights into the long-term medical care and preventive interventions that will benefit the growing population of cancer survivors.

of subsequent cancers.

Keywords: leukemia, other primary neoplasms, age-time-space distribution, synchronous and metachronous occurrence, clinical stages

Published: July 1, 2013  Show citation