Onkologie. 2013:7(4):190-196

Patients with colorectal cancer and their subsequent and previous neoplasms

Edvard Geryk¹, Petr Dítě², Radim Štampach³, Teodor Horváth⁴, Jiří Kozel³

¹ Oddělení vědy a výzkumu, Fakultní nemocnice Brno

² II. interní klinika LF MU, Fakultní nemocnice Brno

³ Geografický ústav, Masarykova univerzita, PřF, Brno

⁴ Chirurgická klinika FN Brno, Lékařská fakulta MU, Brno

Among the total of 99,378 new colorectal cancers (CRCs) in males and 78,977 in females, based on the Czech Cancer Registry in 1976–2005, there

were 14,860 (15 %) CRCs in males and 11,142 (14.1 %) in females associated with the other malignant neoplasms (MNs). The primary 6,504 CRCs

in males were followed by 7,406 subsequent MNs, the primary 4,342 CRCs in females by 4,798 subsequent MNs. On the contrary before the

subsequent 8,356 CRCs in males were registered 10,152 primary MNs, 6,800 CRCs in females 7,829 MNs. The number of multiple CRCs increased

from 141 in 1976 to 1,534 in 2005. In 1996–2005 the primary CRCs reached 57 % of early, 30 % advanced and 13 % unknown clinical stages, respectively

the subsequent CRCs of 43.5 %, 34 % and 22.5 %. The occurrence of all multiple CRCs were highest in the age group of 50–69 years

in males, and of 70–79 years in females. The average interval between primary CRCs and subsequent MNs was 5.1 years in males and 5.4 years

in females. The most frequent MNs following primary CRCs were cancers of the gastrointestinal tract, skin, genital organs and urinary tract.

Nearly half of synchronous MNs after primary CRCs were cancers of the gastrointestinal tract. There were 19 % cases diagnosed at advanced

stages from the total 12,204 subsequent MNs, one half of those in patients with gastrointestinal cancers. More than one third of primary MNs

preceded by 17,981 subsequent CRCs were cancers of the skin. Among 1,715 (26.4 %) males and 1,206 (27.8 %) females survived up to 2007 with

primary CRCs, there were higher early stages than with subsequent CRSc; on the contrary among 6,646 (79.5 %) males and 5,291 (77.8 %) females,

died up to 2007 with subsequent CRCs, were higher advanced stages than with primary CRCs. By the above mentioned data is estimated that

among a total of 8,265 CRCs registered in 2010 were nearly 1,700 (21 %) multiple CRCs, i.e. 260 primary and 1,440 subsequent cases. Every

fifth CRC was associated with the occurrence of the other MNs. Although it is difficult to estimate the number of multiple cases among 53,340

survivors with CRCs in 2010, their ongoing trend will increase the burden of diagnostic and therapeutic capabilities.

Keywords: multiple colorectal cancer, primary and subsequent neoplasms, time and space distribution, clinical stages

Published: October 1, 2013  Show citation