Onkologie. 2013:7(5):228-231

Novel approaches in adjuvant radiotherapy for breast cancer

Renata Soumarová
Oddělení radioterapie a onkologie, Komplexní onkologické centrum, Nemocnice Nový Jičín a.s.

Adjuvant radiotherapy is an integral part of partial mastectomy, a fact which is supported by a number of randomized studies. This strategy

provides local control and survival comparable to radical mastectomy. Radiotherapy reduces the five-year risk of local recurrence

approximately by threefold. In the case of partial resection, postoperative radiotherapy is always indicated and the standard duration

is 5–6.5 weeks. Recently, an increasing number of papers on a possible acceleration of the regimen, i.e. reduction in the total time of

irradiation treatment, have emerged. Randomized studies show that even a three-week regimen can be adequate without increasing

the adverse effects of irradiation treatment. Accelerated partial breast irradiation, for which a variety of radiotherapeutic methods can

be used, is a major topic, too. In some cases, it is also possible to utilize novel techniques of radiotherapy. Each of the methods has

advantages and disadvantages, with the most important issue still being the right choice of patients.

Keywords: accelerated radiotherapy, hypofractionated radiotherapy, partial breast irradiation, IMRT technique, breath holding

Published: November 1, 2013  Show citation

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Soumarová R. Novel approaches in adjuvant radiotherapy for breast cancer. Onkologie. 2013;7(5):228-231.
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References

  1. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005; 366: 2087-2106. Go to original source... Go to PubMed...
  2. Whelan TJ, Pignol JP, Levine MN, et al. Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 2010; 362: 513-520. Go to original source... Go to PubMed...
  3. Smith BD, Bentzen SM, Correa CR, et al. Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Int J Radiat Oncol Biol Phys 2011; 81: 59-68. Go to original source... Go to PubMed...
  4. Whelan T, MacKenzie R, Julian J, et al. Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst 2002; 94: 1143-1150. Go to original source... Go to PubMed...
  5. Bentzen SM, Agrawal RK, Aird EG, et al. The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet 2008; 371: 1098-1107. Go to original source... Go to PubMed...
  6. Barnett GC, Wilkinson JS, Moody AM, Wilson CB, Twyman N, Wishart GC, Burnet NG, Coles CE. The Cambridge Breast Intensity-modulated Radiotherapy Trial: patient- and treatment-related factors that influence late toxicity. Clin Oncol (R Coll Radiol). 2011; 23(10): 662-673. Go to original source... Go to PubMed...
  7. Qi XS, Hu A, Wang K, Newman F, Crosby M, Hu B, White J, Li XA. Respiration induced heart motion and indications of gated delivery for left-sided breast irradiation. Int J Radiat Oncol Biol Phys. 2012; 82(5): 1605-1611. Go to original source... Go to PubMed...
  8. Kurtz JM. The clinical radiobiology of breast cancer radiotherapy. Radiother Oncol. 2005; 75(1): 6-8. Go to original source...
  9. Fisher ER, Digram J, Tan-Chiu E, et al. Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) eight-year update of protocol B-17. Cancer 1999, 86: 429-438. Go to original source...
  10. Holli K, Saaristo R, Idoly J, et al. Lumpectomy with or without postoperative for breast cancer with favourable prognostic features: results of a randomized study. Br J Cancer 2001; 84: 164-169. Go to original source... Go to PubMed...
  11. Polgár C, Van Limbergen E, Potter R, et al. Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: Recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009). Radiat Oncol 2010; 94: 264-273. Go to original source... Go to PubMed...
  12. Smith BD, Arthur DW, Buchholz TA, et al. Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO). Int J Radiat Oncol Biol Phys 2009; 74: 987-1001. Go to original source... Go to PubMed...
  13. Shah C, Vicini F, Wazer DE, Arthur D, Patel RR. The American Brachytherapy Society consensus statement for accelerated partial breast irradiation. Brachytherapy. 2013; 12(4): 267-277.
  14. McCormick B. Partial-breast radiation for early staged breast cancers: hypothesis, existing data, and a planned phase III trial. JNCCN 2005; 3: 301-307. Go to original source... Go to PubMed...
  15. Polgar C, Strnad V, Major T. Brachytherapy for partial breast irradiation: the European experience. Semin Radiat Oncol 2005; 15: 116-122. Go to original source... Go to PubMed...
  16. Orecchia R, Ciocca M, Tosi G, Franzetti S, Luini A, Gatti G, et al. Intraoperative electron beam radiotherapy (ELIOT) to the breast: a need for a quality assurance programme. Breast 2005; 14: 541-546. Go to original source... Go to PubMed...
  17. Vaidya JS, Baum M, Tobias JS, D'Souza DP, Naidu SV, Morgan S, et al. Targeted intra-operative radiotherapy (Targit): an innovative method of treatment for early breast cancer. Ann Oncol 2001; 12: 1075-1080. Go to original source... Go to PubMed...
  18. Vaidya JS,  Baum M,  Tobias JS,  Wenz F,  Massarut S, Keshtgar M, Hilaris B,  Saunders C,  Williams NR, Brew-Graves C, Corica T, Roncadin M, Kraus-Tiefenbacher U, Sütterlin M, Bulsara M, Joseph D Long-term results of targeted intraoperative radiotherapy (Targit) boost during breast-conserving surgery. Int J Radiat Oncol Biol Phys. 2011; 81(4): 1091-1097. Go to original source... Go to PubMed...
  19. Welzel G, Boch A, Sperk E, Hofmann F, Kraus-Tiefenbacher U, Gerhardt A, Suetterlin M, Wenz F. Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomized phase III trial TARGIT-A. Radiat Oncol. 2013, 7; 8(1): 9. Go to original source... Go to PubMed...
  20. Sperk E, Welzel G, Keller A, Kraus-Tiefenbacher U, Gerhardt A, Sütterlin M, Wenz F. Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A. Breast Cancer Res Treat. 2012; 135(1): 253-260. Go to original source... Go to PubMed...
  21. Bartelink H, Bourgier C, Elkhuizen P. Has partial breast irradiation by IORT or brachytherapy been prematurely introduced into the clinic? Radiother Oncol. 2012; 104(2): 139-142. Go to original source... Go to PubMed...




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