Onkologie. 2013:7(5):231-235

The new treatment possibilities of the primary unresectable liver tumors

Vladislav Třeška¹, Jakub Fichtl¹, Daniel Lysák², František Šlauf³, Václav Liška¹, Alan Sutnar¹, Tomáš Skalický¹, Jiří Ferda³, Petr Duras³, Jan Brůha¹, Jindřich Fínek⁴

¹ Chirurgická klinika FN a LFUK v Plzni

² Hematoonkologické oddělení FN v Plzni

³ Radiodiagnostická klinika FN a LFUK v Plzni

⁴ Radioterapeutické oddělení FN a LFUK v Plzni

Introduction: Insufficient future liver remnant volume (FLRV) is the main cause of liver tumors unresectability. Portal vein embolization

(PVE) with application of hematopoietic stem cells (HSC) can be a matter how to increase resectability of liver tumors.

Method: PVE with application of HSC were performed in 12 patients with primary unresectable liver tumors.

Results: The procedures were without complications. After 4 weeks the sufficient FRLV grew. Radical liver resection was performed in 8

patients. Tumor progression was pattern in 2 patients and in one patients the sever intraabdominal adhesions were cause of inoperability.

One patient is just after PVE and HSC application. Overall survival in one and three years is 66.7 %, resp. 33.3 %. Median of progression

free survival is 6 months.

Conclusion: Combination of PVE with application of HSC is the promised method for increasing resectability of primary unresectable

liver tumors.

Keywords: liver tumors, future liver remnant volume, portal vein embolization, hematopoietic stem cells, liver resection

Published: November 1, 2013  Show citation