Onkologie. 2014:8(6):257-258

Molecular genetics in gastrointestinal stromal tumors

Magdalena Uvírová^1,2, Jarmila Šimová^1,2, Barbora Kubová², Jana Žmolíková^1,2, Irena Urbanovská^1,2, Jana Dvořáčková^1,2,3, Arnošt Martínek^1,4, Dušan Žiak¹, Petr Dítě^1,2,4

¹ Lékařská fakulta Ostravské univerzity v Ostravě

² CGB laboratoř a.s., Ostrava

³ Ústav patologie FN Ostrava

⁴ Interní klinika FN Ostrava

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract (GI) arising from the interstitial cells of Cajal,

primarily of the stomach and small intestine. During the past decade came up to progress of molecular targeted therapies for many

solid tumors and in association with discovery of onkogenic kinase mutations in GISTs to rapid evolution in understanding of molecular

biology features of these tumors and to implementation tyrosine kinase inhibitors in clinical practice. Therefore molecular genotyping

of this lesions is very important for prognosis, therapy, primary or secondary resistence to targeted therapy respectively.

Keywords: Gastrointestinal stromal tumor, mutation, KIT gene, PDGFRA gene

Published: December 15, 2014  Show citation