Onkologie. 2015:9(1):7-9

Adoptive T cell therapy in cancer treatment

Kateřina Vávrová, Jiřina Bartůňková, Rudolf Horváth

Ústav imunologie, Univerzita Karlova, 2. lékařská fakulta, Fakultní nemocnice Motol, Praha

The aim of current immunotherapeutic approaches is to harness the individual’s immune system towards a tumor tissue to eliminate or,

at least, to control proliferation of the neoplastic cells. Among the cancer treatment strategies, the adoptive T cell transfer is progressively

developing method that uses an ex vivo modified and expanded tumor-specific T cells as a tool to target and destroy the neoplastic tumor

cells. The efficacy of the adoptive T cell therapy has significantly improved in recent years due to a better understanding of the molecular

mechanisms that control the interactions of immune system and tumor cells. Promising results have already been achieved within the

clinical trials in malignant melanoma, renal cancer and lymphoid leukemia. The adoptive T cell therapy is therefore gradually finding

its place among the other immunotherapeutic strategies and expands the spectrum of available treatment options in cancer therapy.

Keywords: anti-cancer immunotherapy, adoptive T cell transfer, tumor-specific lymphocytes

Published: March 10, 2015  Show citation