Onkologie. 2015:9(1):34-37

Neurooncological aspects in patiens with pharmacoresistant epilepsy

Jan Chrastina^1,2, Dušan Hrabovský¹, Markéta Hermanová², Petr Burkoň⁴, Milan Brázdil^2,5, Zdeněk Novák^1,2

¹ Neurochirurgická klinika LF MU a FN u sv. Anny v Brně

² CEITEC MU Brno

³ Patologicko anatomický ústav LF MU a FN u sv. Anny v Brně

⁴ Masarykův onkologický ústav Brno

⁵ I. neurologická klinika LF MU a FN u sv. Anny v Brně

Malformations of cortical development and benign brain tumors are frequent causes of long lasting pharmacoresistant epilepsy in paediatric

and adult patients. Such patients are surgically treated and subsequently followed in epileptosurgical centers. Tumor upgrading

in patients with pharmacoresistant epilepsy is only rarely encountered and the development of malignant brain tumor in a patient with

malformation of cortical development is an exception. The aim of the paper is to present two cases of patients suffering from intractable

epilepsy with unexpected development of malignant brain tumor. There was upgrading of low grade glioma (verified by repeated

biopsy sampling) in one patient with chronic epilepsy with final diagnosis glioblastoma multiforme. An exceptional development of

glioblastoma in hemimegalencephalic hemisphere was described in the second patient.

Keywords: pharmacoresistant epilepsy, low grade glioma, hemimegalencephaly, glioblastoma multiforme

Published: March 10, 2015  Show citation