Onkologie. 2015:9(3):129-134

Guidelines for the targeted antifungal therapy of invasive fungal infection in pediatric hematology-oncology

Petr Sedláček¹, Vanda Chrenková², Petra Keslová¹, Peter Múdry³, Jaroslav Štěrba³, Júlia Horáková⁴

¹ Klinika dětské hematologie a onkologie, FN v Motole, 2. LF UK, Praha

² Ústav lékařské mikrobiologie, FN v Motole, 2. LF UK, Praha

³ Klinika dětské onkologie, FN a LF MU, Brno

⁴ Klinika detskej hematológie a onkológie, LF UK a DFNsP, Bratislava

Invasive fungal infections (IFI) in immunocompromised children are associated with significant morbidity and mortality. Early targeted

therapy is the key factor for successful outcome. However, treatment options against IFI in children are limited. Not always it is easy to timely

and to accurately confirm the diagnosis of IFI and properly identify the etiologic agent. Use of several available potent antifungals in children

is complicated by the lack of pharmacokinetic and safety data. In our report, we would like to summarize current recommendations for

targeted antifungal therapy in pediatric hemato-oncology based on our experience and recommendations published during the last years.

Keywords: guidelines, targeted therapy, antifungals, activity, invasive fungal infection, children

Published: June 1, 2015  Show citation