Onkologie. 2015:9(3):146-150

Is there any place for radiotherapy in ovarian carcinoma treatment?

Miluše Dolečková, Dana Králová, Jana Kutová, Alena Chourová, Petr Berkovský, Jana Rusinová

Onkologické oddělení, Nemocnice České Budějovice, a.s.

Introduction: Ovarian carcinoma is high mortality disease despite of radical surgery and introduction of chemotherapeutical regimes

with platinum derivates. Recurrence is more then 60 % (first of all intraperitoneal) and majority of patients dies within 5 years.

Objective: The aim of retrospective study was to evaluate whole abdomino-pelvic radiotherapy for stadium III patients followed after

surgery and 6 series of chemotherapy (CHT).

Study group: Group of 211 ovarian cancer patients were treated in Department of oncology of Hospital Ceske Budejovice between 1985

and 1999, retrospective evaluation was made for 206 of them. 106 of them was with stadium III (51,4 %). Total hysterectomy and bilateral

adnexectomy (HE+AE) was in 37,4 % and total hysterectomy and bilateral adnexectomy and omentectomy (HE+AE+OE) only in 26,7 % (n

= 206). CHT was administered in 86,9 %, radiotherapy (RT) in 66 % (whole abdominal radiotherapy in 80,2 %).

Methods: Kaplan-Meier method was used for survival evaluation.

Results: Overall survival rates at 5 resp. 10 years for stadium III were 57,5 % resp. 46,3 % for all three at that time radical treatment combinations

versus 35,9 % resp. 28,9 % to the rest. Toxicity was not evaluated because of nonsignificant results.

Conclusion: Whole abdominal radiotherapy improved survival rate of patients in risk.

Keywords: ovarian carcinoma, surgery, chemotherapy, whole abdominal radiotherapy

Published: June 1, 2015  Show citation