Onkologie. 2015:9(4):171-174

Strategies for surgical management of synchronous colorectal liver metastases

Vladimír Frýba, Jan Ulrych
I. chirurgická klinika 1. LF UK a VFN v Praze

Up to 25 % of newly diagnosed patients with colorectal cancer will have synchronous liver metastases at presentation. Liver resection is

the most efficacious and the only potentially curative treatment option for patiens with colorectal liver metastases and in combination

with systemic anticancer treatment further improves overall survival. Certain controversies in the surgical intervention strategy of the

primarily resectable liver metastases are still present. All 3 operative approaches (simultaneous, classic staged, and liver-first) evince

comparable results in terms of disease recurrence and overall survival. The following review aims to analyze current treatment options for

synchronous colorectal liver metastases focusing on the diagnostic imaging, resectability criteria and surgical management strategies.

Keywords: colorectal cancer, synchronous liver metastases, simultaneous resection, staged resection

Published: September 18, 2015  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Frýba V, Ulrych J. Strategies for surgical management of synchronous colorectal liver metastases. Onkologie. 2015;9(4):171-174.
Download citation

References

  1. Národní onkologický registr. Dostupný na www.svod.cz.
  2. Adam R, De Gramont A, Figueras J, et al. The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus. Oncologist. 2012; 17(10): 1225-1239. Go to original source... Go to PubMed...
  3. Pawlik TM, Scoggins CR, Zorzi D, et al. Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg. 2005; 241(5): 715-22, discussion 722-724. Go to original source... Go to PubMed...
  4. Ng WW, Cheung YS, Wong J, et al. A preliminary analysis of combined liver resection with new chemotherapy for synchronous and metachronous colorectal liver metastasis. Asian J Surg. 2009; 32(4): 189-197. Go to original source... Go to PubMed...
  5. Akgül Ö, Çetinkaya E, Ersöz Ş, et al. Role of surgery in colorectal cancer liver metastases. World J Gastroenterol. 2014; 20(20): 6113-6122. Go to original source...
  6. Adams RB, Aloia TA, Loyer E, et al. Selection for hepatic resection of colorectal liver metastases: expert consensus statement. HPB (Oxford). 2013; 15(2): 91-103. Go to original source... Go to PubMed...
  7. Leen E, Ceccotti P, Moug SJ, et al. Potential value of contrast-enhanced intraoperative ultrasonography during partial hepatectomy for metastases: an essential investigation before resection? Ann Surg. 2006; 243(2): 236-240. Go to original source... Go to PubMed...
  8. Matsui T, Kitamura T, Ozawa H, et al. Analysis of treatment that includes both hepatic and pulmonary resections for colorectal metastases. Surg Today. 2014; 44(4): 702-711. Go to original source... Go to PubMed...
  9. Kanas GP, Taylor A, Primrose JN, et al. Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors. Clin Epidemiol. 2012; 4: 283-301. Go to original source... Go to PubMed...
  10. Adam R, de Haas RJ, Wicherts DA, et al. Is hepatic resection justified after chemotherapy in patients with colorectal liver metastases and lymph node involvement? J Clin Oncol. 2008; 26(22): 3672-3680. Go to original source... Go to PubMed...
  11. Castellanos JA, Merchant NB. Strategies for Management of Synchronous Colorectal Metastases. Curr Surg Rep. 2014; 2: 62. Go to original source... Go to PubMed...
  12. Martin RC 2nd, Augenstein V, Reuter NP, et al. Simultaneous versus staged resection for synchronous colorectal cancer liver metastases. J Am Coll Surg. 2009; 208(5): 842-850; discussion 850-852. Go to original source... Go to PubMed...
  13. Mayo SC, Pulitano C, Marques H, et al. Surgical management of patients with synchronous colorectal liver metastasis: a multicenter international analysis. J Am Coll Surg. 2013; 216(4): 707-716; discussion 716-8. Go to original source... Go to PubMed...
  14. Bolton JS, Fuhrman GM. Survival after resection of multiple bilobar hepatic metastases from colorectal carcinoma. Ann Surg. 2000; 231(5): 743-751. Go to original source... Go to PubMed...
  15. Slesser AA, Simillis C, Goldin R, et al. A meta-analysis comparing simultaneous versus delayed resections in patients with synchronous colorectal liver metastases. Surg Oncol. 2013; 22(1): 36-47. Go to original source...
  16. Yin Z, Liu C, Chen Y, et al. Timing of hepatectomy in resectable synchronous colorectal liver metastases (SCRLM): Simultaneous or delayed? Hepatology. 2013; 57(6): 2346-2357. Go to original source... Go to PubMed...
  17. de Jong MC, van Dam RM, Maas M, et al. The liver-first approach for synchronous colorectal liver metastasis: a 5-year single-centre experience. HPB (Oxford). 2011; 13(10): 745-752. Go to original source... Go to PubMed...
  18. de Rosa A, Gomez D, Brooks A, Cameron IC. "Liver-first" approach for synchronous colorectal liver metastases: is this a justifiable approach? J Hepatobiliary Pancreat Sci. 2013; 20(3): 263-270. Go to original source... Go to PubMed...
  19. Zendel A, Lahat E, Dreznik Y, et al. "Vanishing liver metastases"-A real challenge for liver surgeons. Hepatobiliary Surg Nutr. 2014; 3(5): 295-302. doi: 10.3978/j.issn.2304-3881.2014.09.13.
  20. Cai GX, Cai SJ. Multi-modality treatment of colorectal liver metastases. World J Gastroenterol. 2012; 18(1): 16-24. Go to original source... Go to PubMed...
  21. de Mestier L, Manceau G, Neuzillet C, et al. Primary tumor resection in colorectal cancer with unresectable synchronous metastases: A review. World J Gastrointest Oncol. 2014; 6(6): 156-169. Go to original source... Go to PubMed...




Oncology

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.