Onkologie. 2015:9(5):221-225

Complex therapy of meningiomas - single centre experience

Miloš Duba, Andrej Mrlian, Josef Musil, Martin Smrčka, Marek Bradávka
Neurochirurgická klinika LF MU a FN Brno

Meningiomas are usually slow-growing tumors, which arise from arachnoideal cells and represent about one third of all primary intracranial

tumors. They occur more frequently in women. Clinical manifestations of meningiomas depend on location and tumor size. In

therapy, surgical treatment is mostly applied; the success rate is associated with the amount of the resection. Another treatment modality

is radiotherapy, hormonal therapy remains on experimental field.

Material a methods: Authors describe their experiences with the diagnosis, the therapy and with the follow up of the patients with

meningioma (n = 552).

Results and conclusion: Despite of mostly benign histology of meningiomas, their recurrence may be relatively frequent and oscillates

between 10 to 30 % often depends of the extension of the operation. Therefore, it is necessary to follow up these patients in compliance

with regular monitoring using MR imaging.

Keywords: meningioma, diagnostics, treatment, follow up

Published: December 1, 2015  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Duba M, Mrlian A, Musil J, Smrčka M, Bradávka M. Complex therapy of meningiomas - single centre experience. Onkologie. 2015;9(5):221-225.
Download citation

References

  1. Kozler P et al.. Intrakraniální nádory 1. vydání Praha: Galén 2007.
  2. Wiemels J, Wrensch M, Claus EB. Epidemiology and etiology of meningioma. J Neurooncol. 2010; 99(3): 307-314. Epub 2010 Sep 7. Go to original source...
  3. Larjavaara S, Haapasalo H, Sankila R, Helén P, Auvinen A. Is the incidence of meningiomas underestimated? A regional survey. British Journal of Cancer 2008; 99: 182-184. Go to original source... Go to PubMed...
  4. Kane AJ, Sughrue ME, Rutkowski MJ, Shangari G, Fang S, McDermott MW, Berger MS, Parsa AT. Anatomic location is a risk factor for atypical and malignant meningiomas. Cancer 2011; 117(6): 1272-1278. Go to original source... Go to PubMed...
  5. Dumanski JP, Carlbom E, Collins VP, et al.. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 1987; 84: 9275-9279. Go to original source...
  6. Seizinger BR, de la Monte S, Atkins L, et al.. Molecular genetic approach to human meningioma: loss of genes on chromosome 22. Proc Natl Acad Sci U S A 1987; 84: 5419-5423. Go to original source...
  7. Koehorst SG, Jacobs HM, Thijssen JH, Blankenstein MA. Detection of an oestrogen receptor-like protein in human meningiomas by band shift assay using a synthetic oestrogen responsive element (ERE). Br J Cancer. 1993; 68(2): 290-294. Go to original source... Go to PubMed...
  8. Perrot-Applanat M, Groyer-Picard MT, Kujas M. Immunocytochemical study of progesterone receptor in human meningioma. Acta Neurochir (Wien). 1992; 115(1-2): 20-30. Go to original source... Go to PubMed...
  9. Bendszus M, Rao G, Burger R, Schaller C, Scheinemann K, Warmuth-Metz M, Hofmann E, Schramm J, Roosen K, Solymosi L. Is there a benefit of preoperative meningioma embolization? Neurosurgery. 2000; 47(6):1306-1311; discussion 1311-1322. Go to original source... Go to PubMed...
  10. Sughrue ME, Kane AJ, Shangari G, Rutkowski MJ, McDermott MW, Berger MS, Parsa AT. The relevance of Simpson Grade I and II resection in modern neurosurgical treatment of World Health Organization Grade I meningiomas. J Neurosurg. 2010; 113(5): 1029-1035. Go to original source...
  11. Palma L, Celli P, Franco C, Cervoni L, Cantore G. Long-term prognosis for atypical and malignant meningiomas: a study of 71 surgical cases. Neurosurg Focus. 1997; 2(4). Go to original source...
  12. Palma L, Celli P, Franco C, et al. Long-term prognosis for atypical and malignant meningiomas: a study of 71 surgical cases. J Neurosurg 1997;86: 793-800. Go to original source...
  13. Pollock BE, Stafford SL, Utter A, Giannini C, Schreiner SA. Stereotactic radiosurgery provides equivalent tumor control to Simpson Grade 1 resection for patients with small- to medium-size meningiomas. Int J Radiat Oncol Biol Phys. 2003; 55(4): 1000-1005. Go to original source...
  14. Pannullo SC, Fraser JF, Moliterno J, Cobb W, Stieg PE. Stereotactic radiosurgery: a meta-analysis of current therapeutic applications in neuro-oncologic disease. J Neurooncol. 2011; 103(1): 1-17. Go to original source...
  15. Náhlovský J et al.. Neurochirurgie 1. vydání Praha: Galén 2006.
  16. Younis GA, Sawaya R, DeMonte F, et al. Aggressive meningeal tumors: review of a series. J Neurosurg 1995; 82: 17-27. Go to original source... Go to PubMed...
  17. DeMonte F et al. Al-Mefty?s Meningiomas 2nd Edition New York: Thieme Medical Publishers, Inc. 2011. Go to original source...
  18. Alexiou GA, Markoula S, Gogou P, Kyritsis AP. Genetic and molecular alterations in meningiomas. Clin Neurol Neurosurg. 2011; 113(4): 261-267. Go to original source... Go to PubMed...
  19. Schul DB, Wolf S, Krammer MJ, Landscheidt JF, Tomasino A, Lumenta CB. Meningioma surgery in the elderly: Outcome and validation of two proposed grading scores systems. Neurosurgery. In press 2011 Aug 23. Go to original source...




Oncology

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.