Onkologie. 2016:10(4):196-198 | DOI: 10.36290/xon.2016.043

Extraventricular, supratentorial ependymomas. Two case reports

Ondřej Kalita¹, Miroslav Vaverka¹, Miloslava Zlevorová², Yvona Klementová², Magdalena Megová³

¹ Neurochirurgická klinika LF UP a FN Olomouc

² Onkologická klinika LF UP a FN Olomouc

³ Ústav molekulární a translační medicíny LF UP v Olomouci

Extraventicular, supratentorial ependymomas are very rare tumors in adults. Thus, factors affecting prognosis are poorly understood.

These case reports present two male patient who was evaluated for first epileptic seazures, respectively for increasing headaches,

nausea and vomiting. Both MRI scans showed extraventricular tumors in right brain temporal lobe. Radical tumor extirpations

were performed. Histology revealed anaplastic ependmoma WHO gr. III. Subsequently, both patients received radiotherapy. The

first patient had tumor recurrencies with repeated surgery and chemotherapies. He expirated 29 months after diagnosis. The

second patient has been showed no tumor recurrency to this date, 77 months after diagnosis. Several studies confirmed tumor

location as an important prognostic factor in adult intracranial ependymomas. However it is seems genetic features to be a more

important biomarker. So far standard treatment of these ependymomas stay radical surgery followed by radiotherapy. The lack of

unequivocal rules for chemotherapy in ependymoma recurrency provides an opportunity for using even less common regimens.

Keywords: anaplastic ependymoma, prognosis, survival, biomarkers

Published: August 1, 2016  Show citation