Onkologie. 2018:12(1):29-31 | DOI: 10.36290/xon.2018.007

The role of L1CAM as a prognostic factor in endometrial cancer

Jaroslav Klát, Aleš Mladěnka, Eva Matejková
Gynekologicko-porodnická klinika, Fakultní nemocnice Ostrava

Objective: To summarize the knowledge about the role of L1CAM in endometrial cancer patients.

Methods: Searching MEDLINE of the original studies related to L1CAM and endometrial cancer from 2000 to September 2017 byusing a searching terms: endometrial cancer AND L1CAM.

Results: L1CAM is an independent predictor for poor survival, progression of disease, and is associated with advanced stage,high–risk endometrial cancer. Preoperave selection of patients to lymphadenectomy or postoperative selection of patients totailor adjuvant treatment depending on L1CAM positivity is promising, but should be confirmed by prospective trials.

Keywords: L1CAM, endometrial cancer, prognostic factor

Published: March 1, 2018  Show citation

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Klát J, Mladěnka A, Matejková E. The role of L1CAM as a prognostic factor in endometrial cancer. Onkologie. 2018;12(1):29-31. doi: 10.36290/xon.2018.007.
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    References

    1. Colombo N, Creutzberg C, Amant F, et al. ESMO-ESGO-ESTRO consensus conference on endometrial cancer, diagnosis, tratment and follow-up. Int J Gynecol Cancer 2016; 26: 2-30. Go to original source... Go to PubMed...
    2. Raveh S, Gavert N, Ben Ze'ev A. L1 cell adheion molekule (L1CAM) in invasive tumors. Cancer Lett 2009; 282: 137-145. Go to original source... Go to PubMed...
    3. Huszar M, Pfeifer M, Schirmer U, et al. Up-regulation of L1CAM is linked to los sof hormone receptors and E-cadherin in aggressive subtypes of endometrial carcionomas. J Pathol 2010; 220(5): 551-561. Go to original source... Go to PubMed...
    4. Zeimet AG, Reimer D, Huszar M, et al. L1CAM in early stage type I endometrial cancer. Result of a large multicenter evaluation. J National Cancer Institute 2013; 105(15): 1142-1150. Go to original source...
    5. Bosse T, Nout RA, Stello E, et al. L1 cell adhesion molecule is a strong predictor for distant recurrence and overall survival in early stage endometrial cancer: Pooled PORTEC trial reset. E J Cancer 2014; 50: 2602-2610. Go to original source...
    6. Pasanen A, Tuomi T, Isola J, et al. L1 cell adhesion molecule as a predictor of disease-specific survival and patterns of relapse in endometrial cancer. Int J Gynecol Cancer 2016; 26: 1465-1471. Go to original source...
    7. Dellinger TH, Smith DD, Ouyang Ch, et al. L1CAM is an independent predictor of poor survival in endometrial cancer - An analysis of The Cancer Genome Atlas (TGCA). Gynecol Oncol 2016; 141: 336-340. Go to original source...
    8. Van der Putten LJM, Visser NC, van de Vijver K, et al. L1CAM expression in endometrial carcinomas: an ENITEC collaboration study. B J Cancer 2016; 115: 716-724. Go to original source... Go to PubMed...
    9. Kommoss F, Kommoss F, Grevenkamp F, et al. L1CAM: amending the "low-risk" category in endometrial carcinoma. J Cancer Res Clin Oncol 2017; 143: 255-262. Go to original source... Go to PubMed...
    10. Pasanen A, Loukovaara M, Tuomi T, et al. Preoperative risk stratification of endometrial carcinoma: L1CAM as a biomarker. Int J Gynecol Cancer 2017; 27: 1318-1324. Go to original source...
    11. Smogeli E, Davidson B, Cvancarova M, et al. L1CAM as a prognostic marker in stage I endometrial cancer: a validation study. BMC Cancer 2016; 16: 596-604. Go to original source... Go to PubMed...
    12. Tangen IL, Kopperud R, Visser N, et al. Expression of L1CAM in curettage or high L1CAM level in preoperative blood samples predicts lymf node metastases and poor outcome in endometrial cancer patiens. BJ Cancer 2017; 117: 840-847. Go to original source... Go to PubMed...
    13. Geels YP, Pijnenborg JMA, Gordon BBM, et al. L1CAM expression is related to non-endometrioid histology, and prognostic for poor outcome in endometroid endometrial carcinoma. Pathol Oncol Res 2016; 22: 63-868. Go to original source...
    14. Wojciechowski M, Glowacka E, Wilczinski M, et al. The sL1CAM in sera of patient Arch Gynecol Obstet 2017; 295(1): 225-232. Go to original source...

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