Onkologie. 2018:12(2):56-62 | DOI: 10.36290/xon.2018.012

Precursors of gastric adenocarcinoma

Bohuslava Šašková, Ondřej Daum, Magdaléna Dubová, Kristýna Pivovarčíková, Marián Švajdler
Šiklův ústav patologie, Univerzita Karlova v Praze, Lékařská fakulta v Plzni a Fakultní nemocnice Plzeň,
Bioptická laboratoř, s.r.o., Plzeň

This article provides an update of the clinical and pathological characteristic of precursors of gastric adenocarcinoma. Gastriccarcinogenesis is a multifactorial process involving genetic and environmental factors. The intestinal type of gastric adenocarcinomamost commonly develops through a multistep process beginning with chronic gastritis and progressing through mucosalatrophy, intestinal metaplasia, and dysplasia to carcinoma. Less common gastric cancer precursor lesions include foveolar typeof dysplasia (or foveolar adenoma), pyloric gland adenoma, gastric pit/crypt dysplasia, fundic gland polyp, hyperplastic polyp,and some non-neoplastic hamartomatous polyps. Precursor lesions of the diffuse type of carcinoma (signet-ring cell carcinomain situ and pagetoid spread of signet cells) may be found in a subset of carriers of a CDH1 gene mutations.

Keywords: gastric adenocarcinoma, precursor lesions, gastric polyps

Published: April 1, 2018  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Šašková B, Daum O, Dubová M, Pivovarčíková K, Švajdler M. Precursors of gastric adenocarcinoma. Onkologie. 2018;12(2):56-62. doi: 10.36290/xon.2018.012.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Correa P. The biological model of gastric carcinogenesis. IARC Sci Publ. 2004; 157: 301-310.
    2. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992; 52(24): 6735-6740.
    3. Forman D, Newell DG, Fullerton F, et al. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ 1991; 302(6788): 1302-1305. Go to original source... Go to PubMed...
    4. Nomura A, Stemmermann GN, Chyou PH, et al. Helicobacter pyloriinfection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 1991; 325(16): 1132-1136. Go to original source... Go to PubMed...
    5. Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991; 325(16): 1127-1131. Go to original source... Go to PubMed...
    6. Amieva M, Peek RM Jr. Pathobiology of Helicobacter pylori-induced gastric cancer. Gastroenterology 2016; 150(1): 64-78. Go to original source... Go to PubMed...
    7. Hsing AW, Hansson LE, McLaughlin JK, et al. Pernicious anemia and subsequent cancer. A population-based cohort study. Cancer 1993; 71(3): 745-50. Go to original source... Go to PubMed...
    8. Vannella L, Lahner E, Annibale B. Risk for gastric neoplasias in patients with chronic atrophic gastritis: a critical reappraisal. World J Gastroenterol 2012; 18(12): 1279-1285. Go to original source... Go to PubMed...
    9. Tatsuta M, Iishi H, Nakaizumi A, et al. Fundal atrophic gastritis as a risk factor for gastric cancer. Int J Cancer 1993; 53(1): 70-74. Go to original source... Go to PubMed...
    10. Murphy G, Dawsey SM, Engels EA, et al. Cancer Risk After Pernicious Anemia in the US Elderly Population. Clin Gastroenterol Hepatol 2015; 13(13): 2282-2289.e1-4. Go to original source... Go to PubMed...
    11. Coati I, Fassan M, Farinati F, et al. Autoimmune gastritis: Pathologist's viewpoint. World J Gastroenterol 2015; 21(42): 12179-1289. Go to original source... Go to PubMed...
    12. Sinning C, Schaefer N, Standop J, et al. Gastric stump carcinoma - epidemiology and current concepts in pathogenesis and treatment. Eur J Surg Oncol 2007; 33(2): 133-139. Go to original source... Go to PubMed...
    13. Park YH, Kim N. Review of atrophic gastritis and intestinal metaplasia as a premalignant lesion of gastric cancer. J Cancer Prev 2015; 20(1): 25-40. Go to original source... Go to PubMed...
    14. Dixon MF, Genta RM, Yardley JH, et al. Classification and grading of gastritis: The updated Sydney System. Am J Surg Pathol. 1996; 20(10): 1161-1181. Go to original source... Go to PubMed...
    15. Rugge M, Meggio A, Pennelli G, et al. Gastritis staging in clinical practice: the OLGA staging system. Gut 2007; 56(5): 631-636. Go to original source... Go to PubMed...
    16. Capelle LG, de Vries AC, Haringsma J, et al. The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis. Gastrointest Endosc 2010; 71(7): 1150-1158. Go to original source... Go to PubMed...
    17. Rugge M, Kim JG, Mahachai V, et al. OLGA gastritis staging in young adults and country-specific gastric cancer risk. Int J Surg Pathol 2008; 16(2): 150-154. Go to original source... Go to PubMed...
    18. Rugge M, de Boni M, Pennelli G, et al. Gastritis OLGA-staging and gastric cancer risk: a twelve-year clinico-pathological follow-up study. Aliment Pharmacol Ther 2010; 31(10): 1104-1111. Go to original source... Go to PubMed...
    19. Rugge M, Fassan M, Pizzi M, et al. Autoimmune gastritis: histology phenotype and OLGA staging. Aliment Pharmacol Ther 2012; 35(12): 1460-1466. Go to original source... Go to PubMed...
    20. Dinis-Ribeiro M, Areia M, de Vries AC, et al. Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED). Virchows Arch 2012; 460(1): 19-46. Go to original source... Go to PubMed...
    21. González CA, Sanz-Anquela JM, Gisbert JP, et al. Utility of subtyping intestinal metaplasia as marker of gastric cancer risk. A review of the evidence. Int J Cancer 2013; 133(5): 1023-1032. Go to original source... Go to PubMed...
    22. González CA, Sanz-Anquela JM, Companioni O, et al. Incomplete type of intestinal metaplasia has the highest risk to progress to gastric cancer: results of the Spanish follow-up multicenter study. J Gastroenterol Hepatol 2016; 31(5): 953-958. Go to original source... Go to PubMed...
    23. Bosman FT, Carneiro F, Hruban RH, et al. WHO classification of tumors of the digestive system, 4th ed. Lyon: IARC 2010: 410 s.
    24. Schlemper RJ, Riddell RH, Kato Y, et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut 2000; 47(2): 251-255. Go to original source... Go to PubMed...
    25. Stolte M. The new Vienna classification of epithelial neoplasia of the gastrointestinal tract: advantages and disadvantages. Virchows Arch. 2003; 442(2): 99-106. Go to original source... Go to PubMed...
    26. Abraham SC, Park SJ, Lee JH, et al. Genetic alterations in gastric adenomas of intestinal and foveolar phenotypes. Mod Pathol 2003; 16(8): 786-795. Go to original source... Go to PubMed...
    27. Abraham SC, Montgomery EA, Singh VK, et al. Gastric adenomas: intestinal-type and gastric-type adenomas differ in the risk of adenocarcinoma and presence of background mucosal pathology. Am J Surg Pathol 2002; 26(10): 1276-1285. Go to original source... Go to PubMed...
    28. Park DY, Srivastava A, Kim GH, et al. Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia. Am J Surg Pathol 2008; 32(4): 524-533. Go to original source... Go to PubMed...
    29. Srivastava A, Lauwers GY. Gastric epithelial dysplasia: the Western perspective. Dig Liver Dis 2008; 40(8): 641-649. Go to original source... Go to PubMed...
    30. Sharma P, Montgomery E. Gastrointestinal dysplasia. Pathology 2013; 45(3): 273-285. Go to original source... Go to PubMed...
    31. Valente P, Garrido M, Gullo I, et al. Epithelial dysplasia of the stomach with gastric immunophenotype shows features of biological aggressiveness. Gastric Cancer 2015; 18(4): 720-728. Go to original source... Go to PubMed...
    32. Shin N, Jo HJ, Kim WK, et al. Gastric pit dysplasia in adjacent gastric mucosa in 414 gastric cancers: prevalence and characteristics. Am J Surg Pathol 2011; 35(7): 1021-1029. Go to original source... Go to PubMed...
    33. Agoston AT, Odze RD. Evidence that gastric pit dysplasia-like atypia is a neoplastic precursor lesion. Hum Pathol 2014; 45(3): 446-455. Go to original source... Go to PubMed...
    34. Kim A, Ahn SJ, Park do Y, et al. Gastric crypt dysplasia: a distinct subtype of gastric dysplasia with characteristic endoscopic features and immunophenotypic and biological anomalies. Histopathology 2016; 68(6): 843-849. Go to original source... Go to PubMed...
    35. Vieth M, Kushima R, Borchard F, et al. Pyloric gland adenoma: a clinico-pathological analysis of 90 cases. Virchows Arch 2003; 442(4): 317-321. Go to original source... Go to PubMed...
    36. Vieth M, Vogel C, Kushima R, et al. Pyloric gland adenoma-how to diagnose? Cesk Patol 2006; 42(1): 4-7. Go to PubMed...
    37. Chen ZM, Scudiere JR, Abraham SC, et al. Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma. Am J Surg Pathol 2009; 33(2): 186-193. Go to original source... Go to PubMed...
    38. Vieth M, Montgomery EA. Some observations on pyloric gland adenoma: an uncommon and long ignored entity! J Clin Pathol 2014; 67(10): 883-890. Go to original source... Go to PubMed...
    39. Chlumská A, Waloschek T, Mukenšnabl P, et al. Pyloric gland adenoma: a histologic, immunohistochemical and molecular genetic study of 23 cases. Cesk Patol 2015; 51(3): 137-143. Go to PubMed...
    40. Lee SE, Kang SY, Cho J, et al. Pyloric gland adenoma in Lynch syndrome. Am J Surg Pathol 2014; 38(6): 784-792. Go to original source... Go to PubMed...
    41. Jain R, Chetty R. Gastric hyperplastic polyps: a review. Dig Dis Sci 2009; 54(9): 1839-1846. Go to original source... Go to PubMed...
    42. Ahn JY, Son DH, Choi KD, et al. Neoplasms arising in large gastric hyperplastic polyps: endoscopic and pathologic features. Gastrointest Endosc 2014; 80(6): 1005-1013. Go to original source... Go to PubMed...
    43. Oberhuber G, Stolte M. Gastric polyps: an update of their pathology and biological significance. Virchows Arch 2000; 437(6): 581-590. Go to original source... Go to PubMed...
    44. Vyas M, Yang X, Zhang X. Gastric Hamartomatous Polyps-Review and Update. Clin Med Insights Gastroenterol 2016; (9): 3-10. Go to original source... Go to PubMed...
    45. Brosens LA, Wood LD, Offerhaus GJ, et al. Pathology and genetics of syndromic gastric polyps. Int J Surg Pathol 2016; 24(3): 185-199. Go to original source... Go to PubMed...
    46. Lam-Himlin D, Park JY, Cornish TC, et al. Morphologic characterization of syndromic gastric polyps. Am J Surg Pathol 2010; 34(11): 1656-1662. Go to original source... Go to PubMed...
    47. Worthley DL, Phillips KD, Wayte N, et al. Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. Gut 2012; 61(5): 774-779. Go to original source... Go to PubMed...
    48. Li J, Woods SL, Healey S, et al. Point Mutations in Exon 1B of APC reveal gastric adenocarcinoma and proximal polyposis of the stomach as a familial adenomatous polyposis variant. Am J Hum Genet 2016; 98(5): 830-842. Go to original source... Go to PubMed...
    49. McDuffie LA, Sabesan A, Allgäeuer M, et al. ?-Catenin activation in fundic gland polyps, gastric cancer and colonic polyps in families afflicted by 'gastric adenocarcinoma and proximal polyposis of the stomach' (GAPPS). J Clin Pathol 2016; 69(9): 826-33. Go to original source... Go to PubMed...
    50. Repak R, Kohoutova D, Podhola M, et al. The first European family with gastric adenocarcinoma and proximal polyposis of the stomach: case report and review of the literature. Gastrointest Endosc 2016; 84(4): 718-725. Go to original source... Go to PubMed...
    51. van der Post RS, Vogelaar IP, Carneiro F, et al. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. J Med Genet 2015; 52(6): 361-374. Go to original source... Go to PubMed...

    Return to the content


    Oncology

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.