Onkologie 2020: 14(Suppl.B): 37-39 | DOI: 10.36290/xon.2020.034

Case report of the meaning therapeutical response of the NSCLC after pembrolizumab monotherapy

Jaromír Roubec
Plicní oddělení, Vítkovická nemocnice, a. s., Ostrava-Vítkovice

The authors present a case report of a successful treatment by pembrolizumab in an elderly man with with adenocarcioma of lung. The aim is to show the case of the successfull anticancer therapy in elderly patient, the today standard therapy by immunotherapy outside of clinical trials in the Czech republic.

Keywords: NSCLC, immunotherapy, elderly patients, pembrolizumab, KEYNOTE-024.

Published: June 2, 2020  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Roubec J. Case report of the meaning therapeutical response of the NSCLC after pembrolizumab monotherapy. Onkologie. 2020;14(Suppl.B / Onkologické kazuistiky 2):37-39. doi: 10.36290/xon.2020.034.
Download citation

References

  1. Brahmer J, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010; 28: 3167-3175. Go to original source... Go to PubMed...
  2. Reck M, Rodríguez-Abreu D, Robinson AG, et al. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer. N Engl J Med. 2016 Nov 10; 375(19). Go to original source... Go to PubMed...
  3. Reck M, Rodríguez-Abreu D, Robinson AG, et al. Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50 % or Greater. J Clin Oncol. 2019 Mar 1; 37(7): 537-546. doi: 10.1200/JCO.18.00149. Epub 2019 Jan 8. Go to original source... Go to PubMed...
  4. Gandhi L, Rodríguez-Abreu D, Gadgeel S, et al. Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer. N Engl J Med. 2018 May 31; 378(22): 2078-2092. Go to original source... Go to PubMed...
  5. Aguilar EJ, Ricciuti B, Gainor JF, et al. Outcomes to first-line pembrolizumab in patients with non-small cell lung cancer and very high PD-L1 expression. Ann Oncol. 2019 Oct; 30(10): 1653-1659. Go to original source... Go to PubMed...
  6. Havel L. Is age limiting factor for nivolumab treatment? Onkol Revue 2018; 5(5): 57-59.
  7. www.sukl.cz
  8. Kanesvaran R, Cordoba R, Maggiore R, et al. Immunotherapy in Older Adults With Advanced Cancers: Implications for Clinical Decision-Making and Future Research. American Society of Clinical Oncology Educational Book 2018; 38: 400-414. Go to original source... Go to PubMed...
  9. Kim R, Keam B, Hahn S, et al. Firstline Pembrolizumab Versus Pembrolizumab Plus Chemotherapy Versus Chemotherapy Alone in Non-small-cell Lung Cancer: A Systematic Review and Network Meta-analysis.Clin Lung Cancer. 2019 Sep; 20(5): 331-338. Go to original source... Go to PubMed...




Oncology

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.