Onkologie. 2009:3(1):54-61

Breast cancer and subsequent primary malignant neoplasms in the Czech Republic 1976-2005

Edvard Geryk¹, Marie Bendová², Jiří Kozel³

¹ Fakultní nemocnice Brno Bohunice

² GPK 3. LF UK a FNKV Praha

³ PřF MU Brno

The number of multiple cancers were evaluated among 118 546 women diagnosed with a first primary breast cancer during 1976–2005,

of which 10 352 (52.7 %) were initial and 9 309 (47.3 %) subsequent breast cancers, registered as of 17. 10. 2007. There were 17 085 (14.4 %)

women with two, 2 138 (1.8 %) with three and 438 (0.4 %) with four and more primary cancers. The subsequent 8 509 (43.3 %) breast

cacers were the 2nd, 673 (3.4 %) the 3rd, 87 (0.4 %) the 4th and 40 (0.2 %) the 5th till the 12th diagnosis. The numbers of 10 352 primary

breast cancers increased during 1976–1994 and then decreased, numbers of 9 309 subsequent breast cancers increased till 2004. Total

10 352 women, diagnosed in 22.1 % of stage I, 45.5 % of stage II, 17.7 % of stage III, 4.2 % of stage IV and 10.6 % unknown, were followed

11 522 second primary neoplasms of that the most frequent were cancers of breast 27 %, skin 19.4 %, digestive system 17 % and female

genital system 15.5 %. Total 3 112 bilateral breast cancers accounted 2.6 % of 118 546 cases, registered in Czech Cancer Registry. The

average interval between the breast and subsequent cancer were 6 years, the proportion of synchronous and metachronous cancers

were 1 : 5.1. The average survival interval of 10 352 women with breast multiplicities were 8.1 year, of which 35.1 % women survived and

64.9 % died as of 17. 10. 2007.

Keywords: breast cancer, multiple malignant neoplasms, age and geographical distribution, topography, clinical stages, synchronous and metachronous cancers.

Published: March 1, 2009  Show citation