Onkologie. 2017:11(1):8-10 | DOI: 10.36290/xon.2017.002

Renaissance of immunotherapy in treating kidney cancer

Tomáš Büchler
Onkologická klinika 1. LF UK a Thomayerovy nemocnice, Praha

Renal cell carcinoma (RCC) has traditionally been considered an immunogenic malignancy. Despite this, the majority of existing

immunotherapeutic strategies have brought only little benefit to patients with a generalized tumour. In some clinical settings,

however, a novel generation of immunotherapeutic drugs, particularly those from the group of checkpoint inhibitors, has shown

superiority over standard targeted therapy, while having relatively low toxicity.

Keywords: renal cell carcinoma, immunotherapy, nivolumab, biological therapy

Published: February 1, 2017  Show citation

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Büchler T. Renaissance of immunotherapy in treating kidney cancer. Onkologie. 2017;11(1):8-10. doi: 10.36290/xon.2017.002.
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References

  1. Figlin RA, Thompson JA, Bukowski RM, et al. Multicenter, randomized, phase III trial of CD8(+) tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal cell carcinoma. J Clin Oncol 1999; 17: 2521-2529. Go to original source... Go to PubMed...
  2. Yang JC, Hughes M, Kammula U, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother 2007; 30: 825-830. Go to original source... Go to PubMed...
  3. Rini BI, Stenzl A, Zdrojowy R, et al. IMA901, a multipeptide cancer vaccine, plus sunitinib versus sunitinib alone, as first-line therapy for advanced or metastatic renal cell carcinoma (IMPRINT): a multicentre, open-label, randomised, controlled, phase 3 trial. Lancet Oncol 2016; 17: 1599-1511. Go to original source... Go to PubMed...
  4. Motzer RJ, Escudier B, McDermott DF, et al. Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med 2015; 373: 1803-1813. Go to original source... Go to PubMed...
  5. Plimack ER, Motzer RJ, Escudier B, et al. Two-year Efficacy and Safety Update: Phase III CheckMate 025 Study of Nivolumab vs. Everolimus in Patients With Advanced Renal Cell Carcinoma (aRCC). 2016 NCRI Cancer Conference. http://abstracts.ncri.org.uk/abstract/two-year-efficacy-and-safety-update-phase-iii-checkmate-025-study-of-nivolumab-vs-everolimus-in-patients-with-advanced-renal-cell-carcinoma-arcc//
  6. Cella D, Grünwald V, Nathan P, et al. Quality of life in patients with advanced renal cell carcinoma given nivolumab versus everolimus in CheckMate 025: a randomised, open-label, phase 3 trial. Lancet Oncol 2016; 17: 994-1003. Go to original source... Go to PubMed...




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