Onkologie. 2017:11(6):289-292 | DOI: 10.36290/xon.2017.053

Significance of systemic chemotherapy and hyperthermic intraperitoneal chemotherapy in primary and secondary peritoneal surface malignancies

Beatrice Mohelníková-Duchoňová¹, Radmila Lemstrová¹, Dušan Klos², Jan Hanuliak², Martin Stašek², Čestmír Neoral², Bohuslav Melichar²

¹ Onkologická klinika FN a LF UP v Olomouci

² I. chirurgická klinika FN a LF UP v Olomouci

The peritoneum is a specific organ structure that is often affected by metastatic tumour disease and less frequently so by primary peritonealtumours. In terms of treatment options, it is crucial to distinguish solitary peritoneal involvement from end-stage carcinomatosiswherein, in addition to the peritoneum, multiple metastatic foci are found in parenchymal organs. In the case of disseminated disease,peritoneal carcinomatosis is an incurable form of malignancy with a very poor prognosis and limited therapeutic options. In the caseof solitary peritoneal involvement, whether it be by a primary peritoneal tumour or by a tumour with another primary origin, yet withcarcinomatosis as the only manifestation of disease dissemination, a combination of surgical and oncological treatment can producea major therapeutic benefit, improve the quality of life, and significantly prolong overall survival. Given the progress in oncology andlonger survival of oncological patients, the importance of carcinomatosis treatment has been increasing in recent years. The aim ofthis article is to summarize the current trends and significance of chemotherapy in patients with peritoneal involvement by tumour.

Keywords: peritoneal tumours, systemic oncological therapy, hyperthermic intraperitoneal chemotherapy, peritoneal carcinomatosis

Published: December 1, 2017  Show citation