Onkologie. 2018:12(3):105-110 | DOI: 10.36290/xon.2018.021

Pitfalls in cutaneous lymphoma diagnosis – a pathologists point of view

Kateřina Kamarádová

Fingerlandův ústav patologie, Fakultní nemocnice Hradec Králové

Diagnosis of cutaneous lymphomas is one of the most complex and difficult parts of hematopathology particularly due to widerange of differential diagnosis from group of benign inflammatory lymphoproliferative lesions. Besides morphology, the diagnosisrely upon using immunohistochemisty, in situ hybridization (including fluorescent ISH) and molecular methods, mainly polymerasechain reaction (PCR) testing, to determine the type of B-cell receptor and or T-cell receptor rearrangement in particular.Nevertheless, there still exists a variety of overlapping and lymphoma-like appearing entities which needs to be rule out be forestablishing a diagnosis of malignit lymphoma. Next to the help of ancillary studies, clinical correlation and relevant clinical datasent to the pathologist are one of the most important clues in lymphoma diagnosis. This review article provils an overview ofdiagnostic possibilities in lymphoma diagnosis including current classification of cutaneous lymphomas as well as points outpossible pitfalls and troubles in terms of differential diagnosis of the most common types of cutaneous lymphomas.

Keywords: cutaneous lymphoma, hematopathology, pathology, immunohistochemistry, molecular methods, cutaneous lymphoma
classification

Published: June 1, 2018  Show citation