Onkologie. 2018:12(6):283-286 | DOI: 10.36290/xon.2018.051

The most frequent drug interactions in oncology

Šárka Kozáková^1,2, Roman Goněc¹, Jitka Rychlíčková^1,2, Jan Juřica^1,2

¹ Masarykův onkologický ústav, Brno

² Farmakologický ústav, Lékařská fakulta, Masarykova univerzita, Brno

Medicinal product interactions are a constant problem in treating oncological diseases. Not all drug interactions can be predictedand those which are predictable cannot always be prevented. However, increased awareness of the potential of these interactionsshould enable risk minimization by choosing appropriate medications as well as through monitoring for drug-interactionsymptoms. Mutual potential interactions of cytotoxic drugs and interactions between anticancer medicines and over-the-countermedicinal products or alternative medications and phytopharmaceuticals should not be underestimated. Drug interactions mayoccur at all levels and failure to recognize them may lead to overdose or inadequate treatment with major clinical sequelae. Druginteractions in oncology include interactions in targeted therapy, being paid much attention to in the literature, as well as inclassic cytotoxic drugs.

Keywords: drug interactions, CYP, polypragmazia, side effects, toxicity

Published: December 15, 2018  Show citation