Onkologie. 2018:12(6):288-292 [Urol. praxi. 2018;19(5):228-232]

Consequences of genitourinary malignancies therapy on cardiovascular system

Beata Mladosievičová, Lucia Petríková, Zuzana Poljak Valášková
Oddelenie klinickej patofyziológie, Lekárska fakulta Univerzity Komenského, Bratislava

Cardiovascular toxicity induced by conventional anticancer drugs (anthracyclines and platinum compounds) has historically beena relevant issue of patients with genitourinary malignancies. In addition, targeted and androgen-deprivation therapies can alsoinduce cardiotoxicity in these patients. Immune checkpoint inhibitors are a novel class of effective antineoplastic drugs withcardiotoxicity used in patients with urogenital malignancies. Cardiotoxicity has been long underestimated in clinical practice,but during the last years significant number of patients with serious cardiovascular complications during or after completionof anticancer therapy have been reported. Here we describe cardiotoxicity of the selected prominent drugs used in the field ofurooncology which have received particular attention in recent years.

Keywords: cardiac toxicity, vascular toxicity, cisplatin, androgen-deprivation therapy, checkpoint inhibitors

Published: December 15, 2018  Show citation

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Mladosievičová B, Petríková L, Poljak Valášková Z. Consequences of genitourinary malignancies therapy on cardiovascular system. Onkologie. 2018;12(6):288-292.
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