Onkologie. 2020:14(3):114-116 | DOI: 10.36290/xon.2020.022

Primary mediastinal large B-cell lymphoma: positron emission tomography benefit in clinical practice

Veronika Hanáčková, Vít Procházka

Hemato-onkologická klinika Lékařské fakulty Univerzity Palackého a Fakultní nemocnice Olomouc

Primary mediastinal large B-cell lymphoma is an aggressive B cell lymphoma that is characterised by rapid growth of large tumor mass in anterior mediastinum. In the era of immunochemotherapy. A five year survival rate is 80-90%, even though early relapses occur in part of the patients leading to unfavorable outcome. 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography (18F-FDG PET/CT) is currently widely used in diagnosis, staging of disease and monitoring of therapy. Assessed parameters are not entirely visual assessment using Deauville scoring system, but also additional metric parameters resulting from PET/CT assessment, based on metabolism of fluorodeoxyglucose in tumor cells and microenvironment. With regard to young age of patients and limited localisation in mediastinum, current prognostic factors as IPI are failing. 18F-FDG PET/CT could possibly be strong prognostic factor and could be contributory to early identify poor-risk detection of patients resistant to therapy with poor outcome and thus allow a lead to therapy modification.

Keywords: positron emision tomography, metabolic tumor volume, primary mediastinal large B cell lymphoma, metabolic heterogenity.

Published: June 2, 2020  Show citation