Onkologie. 2022:16(4):212-214 | DOI: 10.36290/xon.2022.040

Treatment of a senior patient with cardiovascular comorbidities using checkpoint inhibitor therapy

Kristián Hrušák1, Tomáš Büchler1, Jana Votrubová2
1 Onkologická klinika, 1. LF UK a Thomayerova nemocnice, Praha
2 Radiodiagnostické oddělení, Thomayerova nemocnice, Praha

This case study describes a long-term survival of a senior patient with metastatic kidney cancer and a number of cardiovascular comorbidities after a treatment by checkpoint inhibitors.

Keywords: kidney cancer, checkpoint inhibitors, geriatric oncology, comorbidities.

Accepted: August 22, 2022; Published: August 24, 2022  Show citation

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Hrušák K, Büchler T, Votrubová J. Treatment of a senior patient with cardiovascular comorbidities using checkpoint inhibitor therapy. Onkologie. 2022;16(4):212-214. doi: 10.36290/xon.2022.040.
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References

  1. Bai X, Yi M, Dong B, et al. The global, regional, and national burden of kidney cancer and attributable risk factor analysis from 1990 to 2017. Exp Hematol Oncol. 2020;9:27. [Cited 2020 Sep 29]. doi: 10.1186/s40164-020-00181-3. Go to original source... Go to PubMed...
  2. Rapoport BL, Westman H. Fast Facts: Managing immune-related Adverse Events in Oncology, Early recognition, prompt intervention, effective management. Karger Publishers, 2019. Go to original source...
  3. Motzer RJ, Tannir NM, McDermott DF, et al. Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma. N Engl J Med. 2018;378(14):1277-1290. doi: 10.1056/NEJMoa1712126. Go to original source... Go to PubMed...
  4. Kalra S, Atkinson BJ, Matrana MR, et al. Prognosis of patients with metastatic renal cell carcinoma and pancreatic metastases. BJU Int. 2016;117(5):761-765. doi: 10.1111/bju.13185. Go to original source... Go to PubMed...
  5. Huang XZ, Gao P, Song YX, et al. Efficacy of immune checkpoint inhibitors and age in cancer patients. Immunotherapy. 2020;12(8):587-603. doi: 10.2217/imt-2019-0124. Go to original source... Go to PubMed...
  6. Paderi A, Fancelli S, Caliman E, et al. Safety of Immune Checkpoint Inhibitors in Elderly Patients: An Observational Study. Curr Oncol. 2021;28(5):3259-3267. [Cited 2021 Aug 25]. doi: 10.3390/curroncol28050283 Go to original source... Go to PubMed...
  7. Gomes F, Lorigan P, Woolley S, et al. A prospective cohort study on the safety of checkpoint inhibitors in older cancer patients - the ELDERS study. ESMO Open. 2021;6(1):100042. doi: 10.1016/j.esmoop.2020.100042. Go to original source... Go to PubMed...
  8. Kanesvaran R, Le Saux O, Motzer R, et al. Elderly patients with metastatic renal cell carcinoma: position paper from the International Society of Geriatric Oncology. Lancet Oncol. 2018;19(6):e317-e326. doi: 10.1016/S1470-2045(18)30125-6. Go to original source... Go to PubMed...
  9. Zeng X, Zhu S, Xu C, et al. Effect of Comorbidity on Outcomes of Patients with Advanced Non-Small Cell Lung Cancer Undergoing Anti-PD1 Immunotherapy. Med Sci Monit. 2020;26:e922576. [Cited 2020 Sep 7]. doi: 10.12659/MSM.922576. Go to original source... Go to PubMed...
  10. Nemoto Y, Ishihara H, Nakamura K, et al. Efficacy and safety of immune checkpoint inhibitors in elderly patients with metastatic renal cell carcinoma. Int Urol Nephrol. 2022;54(1):47-54. doi: 10.1007/s11255-021-03042-y. Go to original source... Go to PubMed...




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