Onkologie. 2023:17(5):346-352 | DOI: 10.36290/xon.2023.065

Opioid treatment of cancer patients in 2023

Michal Kouba
Klinika paliativní medicíny, 1. LF UK a VFN, Praha
Ústav hematologie a krevní transfuze, Praha

Opioids are the mainstay of treatment for moderate (4-7/10 on a numerical scale) and severe (above 7/10) cancer-related pain. In most patients, they rapidly lead to noticeable and satisfactory relief; however, in a proportion of patients, a thorough search for the optimal regimen is required. As for the doctor, knowledge of this particular drug class, experience, patience, and communicative skills are all required. Based on the current literature, the review article describes the perception of opioid treatment by both professionals and lay people and summarizes ethical considerations. In addition to an overview of available opioids and their antagonists, the most common clinical scenarios are presented, adverse effects are summarized, and tips from practice are included.

Keywords: opioids, cancer-related pain, opioid epidemic, palliative care.

Accepted: November 28, 2023; Published: November 29, 2023  Show citation

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Kouba M. Opioid treatment of cancer patients in 2023. Onkologie. 2023;17(5):346-352. doi: 10.36290/xon.2023.065.
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References

  1. Farrer E, Dickman A. New analgesics in cancer pain. Curr Opin Support Palliat Care. 2022;16(2):60-64. Go to original source... Go to PubMed...
  2. Chapman EJ, Edwards Z, Boland JW, et al. Practice review: Evidence-based and effective management of pain in patients with advanced cancer. Palliative Medicine. 2020;34(4): 444-453. Go to original source... Go to PubMed...
  3. Mestdagh F, Steyaert A, Lavandhomme P. Cancer Pain Management: A Narrative review of current concepts, strategies and techniques. Curr. Oncol. 2023;30(7):6838-6858. Go to original source... Go to PubMed...
  4. Wood H, Dickman A, Star A, et al. Updates in palliative care - overview and recent advancements in the pharmacological management of cancer pain. Clin Med (Lond). 2018;18(1):17-22. Go to original source... Go to PubMed...
  5. Jirsová K. Upgrade farmakoterapie nádorové bolesti. Onkologie. 2019;13(2):73-77. Go to original source...
  6. Paice JA, Bohlke K, Barton D, et al. Use of Opioids for Adults With Pain From Cancer or Cancer Treatment: ASCO Guideline. J Clin Oncol. 2023;41(4):914-930. Go to original source... Go to PubMed...
  7. Fallon M, Giusti R, Aielli F, et al. Management of Cancer Pain in Adult Patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2018;29(Suppl 4):iv166-iv191. Go to original source... Go to PubMed...
  8. Saunders C. Care of the dying 3. Control of pain in terminal cancer. Nursing Times. 1959;23:1031-1032.
  9. Prabhakar A, Smith TJ. Fast facts and concepts 417 Total pain. Paliative care network of Wisconsin. Total Pain - Palliative Care Network of Wisconsin. Available from: mypcnow.org.
  10. Culp C, Kim HK, Abdi S. Ketamine use for cancer and chronic pain management. Frontiers in Pharmacology. 2021;(11):1-16. Go to original source... Go to PubMed...
  11. To J, Davis M, Sbrana A, et al. MASCC guideline: cannabis for cancer-related pain and risk of harms and adverse events. Supportive Care Cancer. 2023;31:202. Go to original source... Go to PubMed...
  12. Koojiman NI, Willegers T, Reuser A et al. Are psychedelics the answer to chronic pain: a review of curren literature. Pain Practice. 2023;23:447-458. Go to original source... Go to PubMed...
  13. Aman MM, Mahmoud A, Deer T, et al. The American society of pain and neurosiences best practises and guidelines for the interventional management of cancer-assiociated pain. J. Pain. Res. 2021;14:2139-2164. Go to original source... Go to PubMed...
  14. May J, Liščák R. Effectiveness of Leksell gamma knife hypophysectomy on cancer-related intractable pain - a single-center experience. Neuroendocrinology Letters. 2022;(4)43:102-105. Go to original source...
  15. Lambert GD. Opioids and opioid receptors; understanding pharmacological mechanisms as a key to therapeutic advances and mitigation of the misuse crisis. BJA Open. 2023;6(C):100141. Go to original source... Go to PubMed...
  16. Paul AK, Smith CM, Rahmatullah M, et al. Opioid Analgesia and Opioid-Induced Adverse Effects: A Review. Pharmaceuticals. 2021;14:1091. Go to original source... Go to PubMed...
  17. Fallon MT, Cherny NI. Opioid therapy: optimizing analgesic outcomes. In: Oxford textbook of palliative medicine. Oxford New York; University press: 2015:525-559. Go to original source...
  18. James A, Williams J. Basic opioid Pharmacology - an update. British Journal of Pain. 2020;14(2):115-121. Go to original source... Go to PubMed...
  19. Brennan F, Lohman D, Gwyther L. Access to pain management as a human right. Am J Public Health. 2019;109:61-65. Go to original source... Go to PubMed...
  20. Sullivan MD, Ballantyne JC. Must we reduce pain intensity to treat chronic pain? Pain. 2016;157(1):65-69. Go to original source... Go to PubMed...
  21. Dowell D, Ragan KR, Jones CM, et al. CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022. MMWR Recomm Rep. 2022;71(3):1-95. Go to original source... Go to PubMed...
  22. Lejčko J. Přehled opioidních analgetik. Praktické lékárenství. 2009;5(4):172-175.
  23. Haffajee R, Mello, MM. Drug Companies' Liability for the Opioid Epidemic. N Engl J Med. 2017;377(24):2301-2305. Go to original source... Go to PubMed...
  24. Richards GC. Global, regional, and national consumption of controlled opioids: a cross-sectional study of 214 countries and non-metropolitan territories. Br J Pain. 2022;16(1):34-40. Go to original source... Go to PubMed...
  25. Shalini D, Bruera E. Pain Management for Patients With Advanced Cancer in the Opioid Epidemic Era. Am Soc Clin Oncol Educ Book. 2019;39:24-35. Go to original source... Go to PubMed...
  26. Lewis CES, Schutzer-Weissmann J, Farquhar-Smith P. Opioid use disorder in cancer patients. Current Opinioon in Supportive and Palliative Care. 2023;17(2):98-103. Go to original source... Go to PubMed...
  27. Cherny IN, Ziff-Werman B. Ethical considerations in the relief of cancer pain. Support Care Cancer. 2023;31(7):414. Go to original source... Go to PubMed...
  28. Brueck MK, Sulmasy DP. The rule of Double Effect. Health policy and Law. 2020.
  29. Černý D. Princip dvojího účinku. Praha: Academia; 2016.
  30. Bulls HV, Hamm M, Wasilko M, et al. I Refused to Get Addicted to Opioids: Exploring Attitudes About Opioid Use Disorder in Patients With Advanced Cancer Pain. J Pain. 2023;24(6):1030-1038. Go to original source... Go to PubMed...
  31. Aldolaim S. Ethical Dilemma: Healthcare Surrogate Refusal of OPIOID Administration. Pain Management Nursing. 2021;22:806-810. Go to original source... Go to PubMed...
  32. Sláma O. Opioidní analgetika - opioidy. In: Sláma O, Kabelka L, et al. Paliativní medicína pro praxi. Praha: Galén; 2022: p. 74-86.
  33. Twycross R, Wilcock A, Howard P. Palliative Care Formulary. PCF-6. Nottingham. Palliativedrugs.com. Ltd 2017; p. 381.
  34. Burnod A, Maindet C, George B, et al. A clinical approach to the management of cancer-related pain in emergency situations. Support Care Cancer. 2019;27(8):3147-3157. Go to original source... Go to PubMed...
  35. DeSandre PL, May K. Palliative care in the emergency department. In: Cherny N, Fallon T, Kaasa S, et al. Oxford textbook of palliative medicine. Oxford; 2015: p. 119. Go to original source...
  36. Caraceni A, Hanks G, Kaasa S. Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. Lancet Oncol. 2012;13(2):e58-68. Go to original source... Go to PubMed...
  37. Portenoy KR, Ahmed E. Principles of opioid use in cancer pain. J Clin Oncol. 2014;32(16):1662-1670. Go to original source... Go to PubMed...
  38. Mercadante S. The Need of a Comprehensive Approach in a Condition of Poorly Opioid-Responsive Cancer Pain. J Pain Symptom Manage. 2023;S0885-3924(23)00614-0. Go to original source... Go to PubMed...
  39. Vondráčková D. Transmukózní fentanyl v léčbě průlomové bolesti. Remedia. 2011;21(6):448-451.
  40. Mercadante S, Adile C, Ferrera P, et al. Conversion ratios for opioid switching: a pragmatic study. Support Care Cancer. 2022;31(1):91. Go to original source... Go to PubMed...
  41. Fürst P. The Use of Low-Dose Methadone as Add-On to Ongoing Opioid Treatment in Palliative Cancer Care-An Underrated Treatment? Life (Basel). 2022;12(5):679. Go to original source... Go to PubMed...
  42. Chalker C, O´Neill H, Cranfield H. Efficacy of low-dose and/or adjuvant methadone in palliative medicine. BMJ Support Palliat Care. 2022;12(e6):e730-e735. Go to original source... Go to PubMed...
  43. Davies AN, Leach Ch. Naloxegol for opioid-induced sphincter of Oddi spasm/dysfunction. BMJ Support Palliat Care. 2019;9(4):365-366. Go to original source... Go to PubMed...
  44. Thompson DR. Narcotic analgesic effects on the sphincter of Oddi: a review of the data and therapeutic implications in treating pancreatitis. Am J Gastroenterol. 2001;96(4):1266-1272. Go to original source... Go to PubMed...
  45. Wiffen PJ, Derry S, Naessens K, et al. Oral tapentadol for cancer pain (Review). Cochrane Database of Systematic Reviews. 2015;2015(9):CD011460. Go to original source...
  46. Boland, JW. Tapentadol for the management of cancer pain in adults: an update. Curr Opin Support Palliat Care. 2023;17(2):90-97. Go to original source... Go to PubMed...
  47. Poulsen JL, Brochk Ch, Olesen AE, et al. Clinical potential of naloxegol in the management of opioid-induced bowel dysfunction. Clin Exp Gastroenterol. 2014 Sep 19;7:345-358.Literatura u autora a na www.onkologiecs.cz Go to original source... Go to PubMed...




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