Onkologie. 2012:6(3):143-145

Stem Cell Involvement in Myeloproliferative Neoplasms

Radek C.Skoda

Experimental Hematology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland

Myeloproliferative neoplasms (MPN) are clonal disorders that originate at the level of hematopoietic stem cells. Somatic mutations

such as JAK2V617F can be found in purified hematopoietic stem cells and their progeny. Nevertheless, large inter-individual differences

in the mutant allele burden in the patient’s mature blood cells and in the number of hematopoietic lineages that are involved can be

found. Not all patients with MPN show presence of clonality markers in B lymphocytes and T cells are almost always excluded. In many

MPN patients more than one somatic mutation can be found and the order in which these mutations occur can vary between individual

patients. Mouse models have shown that MPN can be initiated by JAK2V617F without the presence of additional mutations. However, all

mouse models to date are based on polyclonal disease. Understanding the early steps in disease initiation will be important for designing better strategies for the treatment and ultimately cure of MPN.

Klíčová slova: myeloproliferative neoplasms, Janus kinase 2, stem cell hierarchy, disease initiating cell, clonality.

Zveřejněno: 31. červenec 2012  Zobrazit citaci