Slovo úvodem

prim. MUDr. Josef Chovanec, Ph.D.

Onkologie. 2017:11(5):215  

The role of hyperthermic intraperitoneal chemotherapy in the treatment of advanced and recurrent ovarian cancer

Richard Feranec, Josef Chovanec

Onkologie. 2017:11(5):220-223 | DOI: 10.36290/xon.2017.041  

Ovarian cancer is the most common cause of death in gynaecological malignancies. The disease is diagnosed in advanced stagewith peritoneal carcinomatosis in most cases. The treatment is based on primary cytoreductive surgery followed by chemotherapy.Benefit of intraperitoneal chemotherapy in frontline treatment has been confirmed. Currently, the increasing interest inpotential benefit of radical cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC) in frontline ovariancancer treatment and therapy of recurrencies is noted. The results of recent trials are limited and heterogenous. Results of ongoingphase III prospective trials...

The clinical relevance of C-reactive protein in oncogynecology

Tomáš Cacek, Monika Náležinská, Josef Chovanec

Onkologie. 2017:11(5):224-226 | DOI: 10.36290/xon.2017.042  

The review article discusses the possibilities of using C-reactive protein levels not only in its most frequent indication (differentialdiagnosis of acute inflammation in the body), but also analyzes new options for its use in oncology patients within prognostic scoringsystems, the benefits of linking with other biomarkers, or seeking its use as a marker of adaptive immune responses after chemotherapy.

Care for BRCA1 and BRCA2 gene carriers from the gynecologist's point of view

Helena Kolářová

Onkologie. 2017:11(5):228-230 | DOI: 10.36290/xon.2017.043  

The article deals with the issue of care for BRCA1 and BRCA2 gene carriers, it means women with hereditary disposition for breastand ovarian cancer, from the gynecologist's point of view, and summarizes the recommendations for the dispensarization andthe implementation of preventive surgical procedures – adnexectomy with hysterectomy. The importance of caring for BRCA1,2gene mutations is emphasized with regard to the severity of ovarian carcinoma. The article draws attention to the fact that, accordingto the NCCN-modified indication criteria from 2015 and approved by the Society of Medical Genetics and Genomics ofthe ČLS JEP, genetic testing...

Serous tubal intraepithelial carcinoma (STIC)

Gabriel Jelenek, Josef Chovanec

Onkologie. 2017:11(5):232-235 | DOI: 10.36290/xon.2017.044  

High-grade serous carcinomas (HGSC) are group of ovarial, tubal and peritoneal tumors arising from precursor lession most likelyfrom distal part of the fallopian tube. At the time of diagnosis of HGSC are women affected with metastatic sprej of the tumorinto abdominal cavity with 5 year survival of 10–30%. Among women with increased risk of HGSC (the most with BRCA mutation)witch underwent bilateral salpingo-oophorectomy is 4–17% diagnosed with STIC (serous tubal intraepithelial carcinoma) or withinvasive neoplasia a aproximately 80% those tumors are found in ampular part of the fallopian tube.

Palliative care in gynecological oncology – commented case reports

Monika Náležinská, Ondřej Sláma, Josef Chovanec

Onkologie. 2017:11(5):236-243 | DOI: 10.36290/xon.2017.045  

The aim of this study is to present specific symptoms of the patients suffering from advanced gynecologic malingnancies usingcase reports. We breifly summarize the current knowledge, diagnostic and therapeutic algorithm for each diagnosis, but first of all,we accent supportive and paliative type of care (which in some cases co-incidents with oncological therapy). Our recomendation oftreating procedures is demonstrated in a way acceptable and understandable for physicians non-gynecologists. We do not discussacumulation of malignant fluids and problematics of pelvic pain, which are symptoms of other malignant and non-malignant diseases.

Nursing care of surgery wounds after radical vulvectomy per secundam – commented case report from the
perspective of non-medical staff

Marie Dvořáková, Zdeňka Pešová, Monika Náležinská, Josef Chovanec, Jan Dvořák

Onkologie. 2017:11(5):244-247 | DOI: 10.36290/xon.2017.046  

The aim of this article is to present specific nursing techniques used in care of surgery wounds after radical vulvectomy due to carcinomaof the vulva. Briefly we inform about the etiology, diagnostic and treatment management of this disease. We accent nursing proceduresused in case of unfavourable type of healing performed by nursing staff educated in specific type of care of chronic malignant wounds.

Smooth muscle tumors of the uterus of uncertain malignant potential

Monika Náležinská, Petr Škapa, Jiří Špaček, Josef Chovanec

Onkologie. 2017:11(5):248-255 | DOI: 10.36290/xon.2017.047  

Objective: To summarize up to date knowledge of the uterine smooth muscle tumors of uncertain malignat potential and todefine specific predictors of the clinical outcome and to recomend therapeutic guidelines as well as the follow-up regimen.Method: Overview study focused on stratification of the uterine smooth muscle tumors of uncertain malignant potential.Conclusion: Smooth muscle tumours of uncertain malignant potential (STUMP) are rare tumors. The histological diagnosis is mostlypost-operative. The conclusion of histological analysis should predict the clinical outcome based on defined prognostic factors. Thesmall sample size of all reported studies...

News in hormonal therapy for breast cancer

Jan Novotný

Onkologie. 2017:11(5):257-262 | DOI: 10.36290/xon.2017.048  

The present paper deals with the advances in hormone therapy for breast cancer both in post-operative adjuvant indication andin neoadjuvant and palliative indications. The article is aimed at monotherapy with hormonal agents as well as at perspectivecombinations with targeted drugs. Finally the article presents practical advice on how to cope with some adverse treatmenteffects that reduce the quality of life of patients and compliance with treatment.

The use of bevacizumab (Avastin) in treating recurrent cervical cancer

Michal Zikán

Onkologie. 2017:11(5):264-268 | DOI: 10.36290/xon.2017.049  

Recurrent, persistent or metastatic cervical cancer represents a major clinical problem. It is a tumour with a very unfavourableprognosis, being frequently diagnosed in younger women. The treatment options in the case of such a tumour are limited, mainlyinvolving the administration of systemic palliative chemotherapy with a platinum derivative and/or non-platinum combinations inpretreated patients. More recently, it has been possible to utilize the beneficial effect of anti-angiogenic therapy in the palliativetreatment of this disease. The present case report discusses clinical experience with the treatment of recurrent cervical cancer ina young patient...