Onkologie. 2011:5(3):146-151

Prognosis of high-risk group of monoclonal gammopathy of undetermineted significance (MGUS)

Mária Klincová¹, Aneta Mikulášová³, Lucie Kovářová², Viera Sandecká¹, Jakub Radocha⁴, Vladimír Maisnar⁴, Zdeněk Adam¹, Marta Krejčí¹, Luděk Pour¹, Lenka Zahradová¹, Andrea Křivanová¹, Petr Szturz¹, Roman Hájek^1,2

¹ Interní hematoonkologická klinika FN a LF MU Brno

² Oddělení klinické hematologie –, Laboratoř experimentální a buněčné imunoterapie FN Brno

³ Laboratoř molekulární cytogenetiky, Ústav experimentální biologie, Přírodovědecká fakulta,

and smoldering multiple myeloma (SMM)

Monoclonal gammopathy of undeterminated significance (MGUS) and asymptomatic form of myeloma are associated with a long-term

risk of progression to active disease symptomatic multiple myeloma or related malignancy. As far as the malignant transformation of

MGUS is concerned, size and type of the serum monoclonal immunoglobulin (monoclonal protein, M-protein, M-Ig), serum kappa and

lambda free light chain ratio, number of clonal plasma cells in bone marrow, number of clonal plasma cells in peripheral blood, immunophenotype

of plasma cells, and another factors seem to play a predictive role.

Keywords: monoclonal gammopathy of undeterminated significance, asymptomatic form of multiple myeloma, prognosis, progression

Published: July 1, 2011  Show citation