Onkologie. 2016:10(5):228-230 | DOI: 10.36290/xon.2016.049

Prognostic significance of expression of protein p53 in rectal cancer patients treated

David Buka¹, Josef Dvořák², Veronika Sitorová³, Igor Richter⁴, Igor Sirák¹, Radek Zapletal², Zuzana Donátová², Jana Hatlová³, René Vobořil⁵

¹ Klinika onkologie a radioterapie LF UK a FN Hradec Králové

² Onkologická klinika, 1. LF UK a Thomayerova Nemocnice, Praha

³ Fingerlandův ústav patologie LF UK a FN Hradec Králové

⁴ Oddělení klinické onkologie, Krajská nemocnice Liberec, a.s.

⁵ Chirurgická klinika 1. LF UK a Nemocnice Na Bulovce, Praha

with postoperative adjuvant radiotherapy



Background: Tumor suppressor gene TP53 is one of the most frequently mutated genes in human tumors. The aim of the study

was to assess the prognostic significance of the expression of the product of this gene-protein p53 in patients treated with

postoperative adjuvant radiotherapy for locally advanced rectal adenocarcinoma.

Patients and methods: In total 59 patients with locally advanced rectal cancer were studied retrospectively.

Results: The median

expression of protein p53 was 70%. Five-year overall survival according to the median expression of protein p53: p53 < 70 = 53%,

five-year overall survival of p53 > 70 = 57%, logrank: p = 0,86; HR = 0,94. Five-year progression free survival (PFS) according to the

median expression of protein p53: p53 < 70 = 47%, five-year progression free survival of p53 > 70 = 49%, logrank: p = 0,92; HR = 0,97.

Conclusion: The results of this study demonstrate protein p53 expression in locally advanced rectal adenocarcinoma. This study

did not show predictive or prognostic significance of expression of protein p53, which can be caused by a wide range of factors

which influence the expression of protein p53.

Keywords: rectal cancer, radiotherapy, angiogenesis, protein p53

Published: November 1, 2016  Show citation