Onkologie. 2010:4(2):94-100
Breakthrough pain and it’s treatment
- Centrum léčby bolesti KARIM VFN a 1. LF UK Praha
Breakthrough pain (BP) is defined as transitory pain that occurs on a background of relatively well controlled baseline pain. This pain character
can join pain of tumour disease origin but not only that one. Question to specify the character of pain should be common in daily
contact with a patient. To resolve this problem it seems neccessary to provide patients wit rescue mediation with rapid 30 minute onset.
The article comes with analgetics review according to WHO classificaton and suitable for BP and available in the Czech rep. From the point
of fast onset view we are looking for new approaches and application routs practical also for outpatient departments. Intranasal fentanyl
offers such option. When pharmacotherapy is not effective any more, mainly in oncology new invasive methods are being explored.
Keywords: breakthrough pain (BP) rescue medication, Oxford league of analgesics, invasive procedures, nasal spray
Published: May 1, 2010 Show citation
References
- Caraceni A, et al. Portenoy RK, and a Working Group of an IASP Task Force on Cancer Pain. Breakthrough pain characteristics and syndromes in patients with cancer pain. An international survey. Palliative Medicine 2004; 18: 177-183.
Go to original source... 
Go to PubMed... - Davies A. Introduction. In Davies A. editor. Cancer-related Breakthrough Pain. Oxford Pain management library: Oxford University Press; 2007: 7. Go to original source...
- Christrup, et al. Clin Ther 2008; 30(3): 469-481.
- Kaasa, et al. The efficacy of intranasal fentanyl spray treatment of breakthrough pain in cancer patients evaluated in a randomised double blind study. Poster presented at World Congress on Pain, 2008.
- Kršiak M. Farmakoterapie bolestí zad. Bolest 2007; 10(1): 14.
- Kršiak M. Analgetická kombinace paracetamolu s tramadolem. Farmakoterapie 2005; 3: 208-211.
- Lauterburg BH. Analgesics and glutathione. Am. J. Ther. 2002; 9: 225-233. Go to original source... Go to PubMed...
- Mercandante S, Radfbruch L, Davies A, et al. A comparison of ontranasal fentanyl spray with oral transmucosal fentanyl citrat for the treatment of breaktrough cancer pain. Curr Med Res Opin. 2009; 25: 2805-2815. Go to original source... Go to PubMed...
- Metodické pokyny pro farmakoterapii nádorové bolesti SSLB update 2009.
- Metodické pokyny pro farmakoterapii akutní a chronické nenádorové bolesti SSLB update 2009.
- Popper, et al. The efficacy of intranasal fentanyl spray treatment of breakthrough pain in cancer patients evaluated in a randomised double blind study. Poster presented at World Congress on Pain, 2008.
- Portenoy RK, Hagen NA. Breaktrough pain: definition, prevalence and characteristics. Pain 1190; 41: 273-281. Go to original source...
- Vondráčková D. Nové cesty léčení průlomové bolesti. Bolest 2009; 12(3): 153-160.